CD27 and ENO2

Data Source: HiPPIP (Novel)

		CD27	ENO2
Name		CD27 molecule	enolase 2
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Phosphopyruvate Hydratase Complex Photoreceptor Inner Segment Extracellular Space Cytoplasm Cytosol Plasma Membrane Cell Cortex Cell Surface Membrane Growth Cone Neuronal Cell Body Perikaryon Membrane Raft Extracellular Exosome Synaptic Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Magnesium Ion Binding Phosphopyruvate Hydratase Activity Protein Binding Lyase Activity Enzyme Binding Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Apoptotic Process Cell Surface Receptor Signaling Pathway Immunoglobulin Mediated Immune Response T Cell Activation Negative Regulation Of Apoptotic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of T Cell Apoptotic Process Adaptive Immune Memory Response Involving T Cells And B Cells Extrinsic Apoptotic Signaling Pathway CD27 Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Gluconeogenesis Glycolytic Process Response To Xenobiotic Stimulus Response To Estradiol Canonical Glycolysis
Pathways		TNFs bind their physiological receptors	Glycolysis Gluconeogenesis
Drugs		None	2-Phosphoglycolic Acid
GWAS		Crohn's disease ( 26192919 )	No GWAS studies recorded
Novel Interactors		6 novel interactors: CCND2 CHD4 CREBL2 ELF1 ENO2 ETV6	1 novel interactors: CD27
Interacting Genes		8 interacting genes: ACTN2 CD70 CIB1 SIVA1 TRAF2 TRAF3 TRAF5 UHRF2	27 interacting genes: A2M ACD AKT1 ANXA11 BMERB1 C6orf47 ENSA EXOC5 HABP4 HK1 HSF1 IL17B MAP4 MTNR1A NAT9 NDUFS7 POT1 SIGIRR SNUPN ST3GAL2 SUMO4 TERF1 TINF2 TUBA4A UBE2C UBE3A USP2-AS1
Entrez ID		939	2026
HPRD ID		01723	00573
Ensembl ID		ENSG00000139193	ENSG00000111674
Uniprot IDs		P26842	P09104 Q6FHV6
PDB IDs		5TL5 5TLJ 5TLK 7KX0 8DS5	1TE6 2AKM 2AKZ 3UCC 3UCD 3UJE 3UJF 3UJR 3UJS 4ZA0 4ZCW 5EU9 5IDZ 5TD9 5TIJ 7MBH
GO Terms Enriched among Interactors		Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway CD27 Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Apoptotic Process Regulation Of RNA Metabolic Process Cell Death Programmed Cell Death Cytoplasmic Side Of Plasma Membrane Regulation Of Nucleobase-containing Compound Metabolic Process Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Apoptotic Process Metal Ion Binding Regulation Of Programmed Cell Death Regulation Of Gene Expression Actin Filament Uncapping Positive Regulation Of Protein Phosphorylation TORC2 Complex Disassembly Positive Regulation Of Male Germ Cell Proliferation CD27 Receptor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Immune System Process Positive Regulation Of Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Ubiquitin-protein Transferase Activity Regulation Of Primary Metabolic Process Chromatin MRNA Stabilization Protein Autoubiquitination Titin Z Domain Binding TRAF2-GSTP1 Complex TORC1 Complex Assembly	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Translation Elongation Factor Binding Negative Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Negative Regulation Of Cellular Component Organization Regulation Of DNA Biosynthetic Process Positive Regulation Of Organelle Organization Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Positive Regulation Of Chromosome Organization Maintenance Of Protein Location In Mitochondrion Regulation Of Telomere Maintenance Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Chromosome Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomere Organization Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Regulation Of Organelle Organization Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Regulation Of DNA Metabolic Process Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Chromosome, Telomeric Region Establishment Of Protein Localization To Organelle Organelle Organization DNA Biosynthetic Process Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Cilium Assembly Cell Division Microtubule Cytoskeleton Ubiquitin-like Protein Ligase Binding Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Mitotic Cell Cycle Regulation Of TRNA Methylation