CD27 and CD70

Number of citations: 36 (PubMedID 7479974)
Data Source: HPRD (in vivo)

		CD27	CD70
Name		CD27 molecule	CD70 molecule
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Tumor Necrosis Factor Receptor Binding Protein Binding Receptor Ligand Activity
	Biological Process	Apoptotic Process Cell Surface Receptor Signaling Pathway Immunoglobulin Mediated Immune Response T Cell Activation Negative Regulation Of Apoptotic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of T Cell Apoptotic Process Adaptive Immune Memory Response Involving T Cells And B Cells Extrinsic Apoptotic Signaling Pathway CD27 Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	T Cell Mediated Immunity Immune Response B Cell Mediated Immunity Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation B Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Lymphocyte Proliferation Adaptive Immune Memory Response Involving T Cells And B Cells Extrinsic Apoptotic Signaling Pathway CD27 Signaling Pathway
Pathways		TNFs bind their physiological receptors	TNFs bind their physiological receptors
Drugs		None	Cusatuzumab
GWAS		Crohn's disease ( 26192919 )	Asthma ( 32296059 ) Heel bone mineral density x serum urate levels interaction ( 34046847 )
Interacting Genes		8 interacting genes: ACTN2 CD70 CIB1 SIVA1 TRAF2 TRAF3 TRAF5 UHRF2	2 interacting genes: CD27 ELOVL4
Entrez ID		939	970
HPRD ID		01723	18515
Ensembl ID		ENSG00000139193	ENSG00000125726
Uniprot IDs		P26842	A0A0U5JA32 P32970
PDB IDs		5TL5 5TLJ 5TLK 7KX0 8DS5	7KX0
GO Terms Enriched among Interactors		Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway CD27 Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Apoptotic Process Regulation Of RNA Metabolic Process Cell Death Programmed Cell Death Cytoplasmic Side Of Plasma Membrane Regulation Of Nucleobase-containing Compound Metabolic Process Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Apoptotic Process Metal Ion Binding Regulation Of Programmed Cell Death Regulation Of Gene Expression Actin Filament Uncapping Positive Regulation Of Protein Phosphorylation TORC2 Complex Disassembly Positive Regulation Of Male Germ Cell Proliferation CD27 Receptor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Immune System Process Positive Regulation Of Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Ubiquitin-protein Transferase Activity Regulation Of Primary Metabolic Process Chromatin MRNA Stabilization Protein Autoubiquitination Titin Z Domain Binding TRAF2-GSTP1 Complex TORC1 Complex Assembly	Nucleoside Phosphate Biosynthetic Process Proton-transporting ATP Synthase Complex Assembly Purine-containing Compound Biosynthetic Process Mitochondrial Proton-transporting ATP Synthase Complex Assembly Adaptive Immune Memory Response Adaptive Immune Memory Response Involving T Cells And B Cells CD27 Signaling Pathway Fatty Acid Elongation, Monounsaturated Fatty Acid Unsaturated Fatty Acid Metabolic Process Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Phylloquinone Catabolic Process Menaquinone Metabolic Process Menaquinone Catabolic Process Vitamin K Catabolic Process Alkane 1-monooxygenase Activity Fatty Acid Metabolic Process Fatty Acid Elongation, Saturated Fatty Acid Small Molecule Metabolic Process G Protein-coupled Photoreceptor Activity Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Vitamin K Metabolic Process Proton-transporting ATP Synthase Activity, Rotational Mechanism Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Purine-containing Compound Metabolic Process Positive Regulation Of B Cell Differentiation Long-chain Fatty-acyl-CoA Biosynthetic Process Monocarboxylic Acid Metabolic Process Ketone Catabolic Process Proton-transporting ATP Synthase Complex Organophosphate Biosynthetic Process Nucleoside Phosphate Metabolic Process Negative Regulation Of T Cell Apoptotic Process Long-chain Fatty-acyl-CoA Metabolic Process Detection Of Visible Light Vitamin Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Fatty-acyl-CoA Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process Response To Copper Ion Negative Regulation Of Lymphocyte Apoptotic Process Regulation Of B Cell Differentiation Very Long-chain Fatty Acid Metabolic Process Prostanoid Metabolic Process Prostaglandin Metabolic Process ADP Binding Immunoglobulin Mediated Immune Response Regulation Of T Cell Apoptotic Process Carboxylic Acid Metabolic Process