CD27 and ELF1

Data Source: HiPPIP (Novel)

		CD27	ELF1
Name		CD27 molecule	E74 like ETS transcription factor 1
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Chromatin Nucleus Nucleoplasm
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Apoptotic Process Cell Surface Receptor Signaling Pathway Immunoglobulin Mediated Immune Response T Cell Activation Negative Regulation Of Apoptotic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of T Cell Apoptotic Process Adaptive Immune Memory Response Involving T Cells And B Cells Extrinsic Apoptotic Signaling Pathway CD27 Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Regulation Of Cytokine Production Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways		TNFs bind their physiological receptors	RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 regulates transcription of genes involved in interleukin signaling
GWAS		Crohn's disease ( 26192919 )	Alanine aminotransferase levels ( 34315874 ) Aspartate aminotransferase levels ( 34315874 ) Cervical cancer ( 28806749 ) Crohn's disease ( 23266558 ) Eosinophil percentage of white cells ( 32888494 ) Height ( 31562340 ) Keratoconus ( 33649486 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Neutrophil percentage of white cells ( 32888494 27863252 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Spleen volume ( 34128465 ) Systemic lupus erythematosus ( 33272962 27399966 23273568 21044949 ) Total cholesterol levels ( 30275531 )
Novel Interactors		6 novel interactors: CCND2 CHD4 CREBL2 ELF1 ENO2 ETV6	1 novel interactors: CD27
Interacting Genes		8 interacting genes: ACTN2 CD70 CIB1 SIVA1 TRAF2 TRAF3 TRAF5 UHRF2	11 interacting genes: HMGA1 HOXC13 NFE2L2 NFKB1 NFYA NFYB NFYC RB1 REL RUNX1 SP1
Entrez ID		939	1997
HPRD ID		01723	01808
Ensembl ID		ENSG00000139193	ENSG00000120690
Uniprot IDs		P26842	P32519
PDB IDs		5TL5 5TLJ 5TLK 7KX0 8DS5	8BZM
GO Terms Enriched among Interactors		Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway CD27 Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Apoptotic Process Regulation Of RNA Metabolic Process Cell Death Programmed Cell Death Cytoplasmic Side Of Plasma Membrane Regulation Of Nucleobase-containing Compound Metabolic Process Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Apoptotic Process Metal Ion Binding Regulation Of Programmed Cell Death Regulation Of Gene Expression Actin Filament Uncapping Positive Regulation Of Protein Phosphorylation TORC2 Complex Disassembly Positive Regulation Of Male Germ Cell Proliferation CD27 Receptor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Immune System Process Positive Regulation Of Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Ubiquitin-protein Transferase Activity Regulation Of Primary Metabolic Process Chromatin MRNA Stabilization Protein Autoubiquitination Titin Z Domain Binding TRAF2-GSTP1 Complex TORC1 Complex Assembly	Chromatin Transcription Cis-regulatory Region Binding Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein-DNA Complex Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific CCAAT-binding Factor Complex Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Transcription Regulator Complex Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Binding Cellular Response To Peptide Hormone Stimulus DNA-binding Transcription Factor Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Sequence-specific DNA Binding Nucleoplasm Regulation Of Macromolecule Metabolic Process Response To Peptide Hormone Cellular Response To Angiotensin Cellular Response To Hormone Stimulus Regulation Of Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Developmental Process Response To Angiotensin Nucleus Positive Regulation Of Extracellular Matrix Organization Positive Regulation Of Amide Metabolic Process Positive Regulation Of Angiogenesis Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Vasculature Development Molecular Adaptor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Leukocyte Differentiation