CD27 and CREBL2

Data Source: HiPPIP (Novel)

		CD27	CREBL2
Name		CD27 molecule	cAMP responsive element binding protein like 2
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Chromatin Nucleus
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Apoptotic Process Cell Surface Receptor Signaling Pathway Immunoglobulin Mediated Immune Response T Cell Activation Negative Regulation Of Apoptotic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of T Cell Apoptotic Process Adaptive Immune Memory Response Involving T Cells And B Cells Extrinsic Apoptotic Signaling Pathway CD27 Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Signal Transduction Cell Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of D-glucose Import Positive Regulation Of Lipid Biosynthetic Process Protein Stabilization
Pathways		TNFs bind their physiological receptors	None
GWAS		Crohn's disease ( 26192919 )	Height ( 31562340 ) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828 ) Response to fenofibrate (HDL cholesterol levels) ( 27002377 ) Systemic lupus erythematosus ( 23273568 )
Novel Interactors		6 novel interactors: CCND2 CHD4 CREBL2 ELF1 ENO2 ETV6	1 novel interactors: CD27
Interacting Genes		8 interacting genes: ACTN2 CD70 CIB1 SIVA1 TRAF2 TRAF3 TRAF5 UHRF2	6 interacting genes: CREBRF DDIT3 DNMT3L NFE2L2 PKNOX2 UBE2I
Entrez ID		939	1389
HPRD ID		01723	07541
Ensembl ID		ENSG00000139193	ENSG00000111269
Uniprot IDs		P26842	O60519
PDB IDs		5TL5 5TLJ 5TLK 7KX0 8DS5	Not available
GO Terms Enriched among Interactors		Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway CD27 Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Apoptotic Process Regulation Of RNA Metabolic Process Cell Death Programmed Cell Death Cytoplasmic Side Of Plasma Membrane Regulation Of Nucleobase-containing Compound Metabolic Process Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Apoptotic Process Metal Ion Binding Regulation Of Programmed Cell Death Regulation Of Gene Expression Actin Filament Uncapping Positive Regulation Of Protein Phosphorylation TORC2 Complex Disassembly Positive Regulation Of Male Germ Cell Proliferation CD27 Receptor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Immune System Process Positive Regulation Of Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Ubiquitin-protein Transferase Activity Regulation Of Primary Metabolic Process Chromatin MRNA Stabilization Protein Autoubiquitination Titin Z Domain Binding TRAF2-GSTP1 Complex TORC1 Complex Assembly	PERK-mediated Unfolded Protein Response Regulation Of Response To Endoplasmic Reticulum Stress Response To Caloric Restriction Cell Redox Homeostasis Response To Endoplasmic Reticulum Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Protein-DNA Complex ER-nucleus Signaling Pathway Integrated Stress Response Signaling Transcription Coregulator Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Endoplasmic Reticulum Unfolded Protein Response Regulation Of RNA Metabolic Process Positive Regulation Of Glutathione Biosynthetic Process SUMO Conjugating Enzyme Activity Positive Regulation Of Prolactin Signaling Pathway Response To Unfolded Protein DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Determination Of Dorsal Identity CHOP-ATF4 Complex CHOP-ATF3 Complex Regulation Of Glutathione Biosynthetic Process Aflatoxin Catabolic Process Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Adaptive Immune Memory Response Involving T Cells And B Cells Regulation Of Cellular Response To Stress Modification-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription CHOP-C/EBP Complex Regulation Of Transcription By RNA Polymerase II Diaphragm Contraction Negative Regulation Of RNA Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II Transcription Regulator Complex Vascular Associated Smooth Muscle Cell Migration RING-like Zinc Finger Domain Binding Epigenetic Programing Of Female Pronucleus Negative Regulation Of RNA Metabolic Process Adaptive Immune Memory Response Involuntary Skeletal Muscle Contraction Cellular Response To Nitrosative Stress Proteasomal Ubiquitin-independent Protein Catabolic Process Toxin Catabolic Process Negative Regulation Of Hematopoietic Stem Cell Differentiation SUMO Ligase Complex HLH Domain Binding