EFTUD2 and AP2B1

Number of citations of the paper that reports this interaction (PubMedID 28515276)
62

Data Source:
BioGRID (affinity chromatography technology)

		EFTUD2	AP2B1
Description		elongation factor Tu GTP binding domain containing 2	adaptor related protein complex 2 subunit beta 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Cajal Body Membrane Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Endomembrane System Membrane Membrane Coat Clathrin Coat AP-2 Adaptor Complex Clathrin Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Synapse Clathrin-coated Endocytic Vesicle Postsynaptic Endocytic Zone Extrinsic Component Of Presynaptic Endocytic Zone Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding RNA Binding GTPase Activity Protein Binding GTP Binding U5 SnRNA Binding	Signal Sequence Binding Protein Binding Clathrin Binding Clathrin Adaptor Activity Protein-containing Complex Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Response To Cocaine Cellular Response To Xenobiotic Stimulus	Kidney Development Cardiac Septum Development Ventricular Septum Development Intracellular Protein Transport Endocytosis Chemical Synaptic Transmission Neurotransmitter Secretion Heart Development Protein Transport Vesicle-mediated Transport Aorta Development Positive Regulation Of Endocytosis Clathrin Coat Assembly Synaptic Vesicle Endocytosis Coronary Vasculature Development Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Protein Localization To Membrane
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Asthma ( 31619474) Craniofacial microsomia ( 26853712)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 22139419 27863252 32888494) Mean reticulocyte volume ( 32888494) Platelet count ( 22139419 27863252) Platelet distribution width ( 27863252) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		15 interacting genes: ARPC3 CYFIP1 DUX4 GOLM1 GSK3B HINFP LSM8 PIN1 PRPF6 SF3B3 SF3B4 SREK1 SUMO2 USP7 WBP4	60 interacting genes: - ACVR1 AFF4 AP1M1 AP1M2 AP2A2 AP2M1 AP2S1 APC ARF6 ARRB1 ATM ATP23 ATP6V1G1 BUB1 BUB1B CATSPERT CCDC187 CEBPA CLINT1 COL3A1 DHX58 DNAJC5 DSCAM FMNL2 GPANK1 GTF2I HIP1 HPCA HSPB1 KANK2 KIAA0408 KPNA2 LDLRAP1 LONRF1 MEA1 MLH1 NECAP2 NEU4 NUP54 PIP5K1C POM121 PSORS1C2 RAPGEF3 RIBC2 SLC25A6 SLC2A8 SMAD4 SMURF1 SNAP91 TENT5C TERF2IP TEX12 TGFBR1 TGFBR2 THAP1 TUBGCP4 TXN2 U2AF1 UBC
Entrez ID		9343	163
HPRD ID		04869	03015
Ensembl ID		ENSG00000108883	ENSG00000006125
Uniprot IDs		B3KX19 Q15029	A0A140VJE8 P63010 Q96EL6
PDB IDs		3JCR 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9 6ZYM 7AAV 7ABF 7ABG 7ABI 7DVQ 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8Q7N 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RC0 8RM5 8RO2 8Y6O 9FMD	1E42 2G30 2IV8 2IV9 2JKR 2JKT 2VGL 2XA7 4UQI 5M5R 6QH5 6QH6 6QH7 6URI 6YAE 6YAF 6YAH 6YAI 7OG1 7OHO 7OM8 7Z5C
Enriched GO Terms of Interacting Partners?		U2-type Precatalytic Spliceosome Spliceosomal Complex MRNA Splicing, Via Spliceosome Precatalytic Spliceosome RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Processing Negative Regulation Of Protein Catabolic Process Spliceosomal Complex Assembly MRNA Metabolic Process Nucleoplasm Regulation Of Protein Catabolic Process RNA Processing RNA Metabolic Process Negative Regulation Of Protein Metabolic Process Nucleic Acid Metabolic Process U2-type Prespliceosome Assembly U12-type Spliceosomal Complex Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process U2 SnRNP Postsynaptic Cytosol U2-type Spliceosomal Complex Negative Regulation Of Catabolic Process Positive Regulation Of RNA Biosynthetic Process Nucleus Positive Regulation Of DNA-templated Transcription Regulation Of Ubiquitin-dependent Protein Catabolic Process Nuclear Speck Cellular Component Assembly Positive Regulation Of Transcription By RNA Polymerase II U4/U6 X U5 Tri-snRNP Complex Positive Regulation Of RNA Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Tau Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Regulation Of Microtubule Anchoring At Centrosome Cis-trans Isomerase Activity Growth Cone Leading Edge Protein-RNA Complex Assembly Nucleobase-containing Compound Metabolic Process Postsynapse Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Leading Edge Glutamatergic Synapse Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleic Acid Binding Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development	Clathrin Adaptor Activity SMAD Binding Clathrin Adaptor Complex Clathrin-dependent Endocytosis Clathrin-coated Pit Synaptic Vesicle Endocytosis Regulation Of Receptor-mediated Endocytosis Presynaptic Endocytosis Endocytosis Clathrin Coat Assembly Vesicle-mediated Transport In Synapse Activin Receptor Complex Activin Receptor Activity, Type I Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Activin Receptor Signaling Pathway Receptor-mediated Endocytosis Mitotic Spindle Assembly Checkpoint Signaling Intracellular Protein Transport Clathrin-coated Endocytic Vesicle Membrane Negative Regulation Of Mitotic Metaphase/anaphase Transition Activin Binding Endocytic Vesicle Membrane AP-2 Adaptor Complex Receptor Internalization Clathrin-coated Vesicle Membrane Clathrin Binding Protein Transport Transmembrane Receptor Protein Serine/threonine Kinase Activity Clathrin-coated Vesicle Negative Regulation Of Chromosome Organization Ventricular Septum Morphogenesis Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of SMAD Protein Signal Transduction Import Into Cell Regulation Of Endocytosis Vesicle-mediated Transport I-SMAD Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA-dependent Protein Kinase Activity Transforming Growth Factor Beta Ligand-receptor Complex Transforming Growth Factor Beta Receptor Signaling Pathway Endolysosome Membrane Positive Regulation Of Receptor-mediated Endocytosis Transforming Growth Factor Beta Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Cellular Component Organization Establishment Of Protein Localization Positive Regulation Of Cellular Component Organization Intracellular Protein Localization
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