GLP2R and GCG

Number of citations of the paper that reports this interaction (PubMedID 11738243)
0

Data Source:
HPRD (in vitro, in vivo)

		GLP2R	GCG
Description		glucagon like peptide 2 receptor	glucagon
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Plasma Membrane Secretory Granule Lumen
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Glucagon Receptor Activity Peptide Hormone Binding	Signaling Receptor Binding Hormone Activity Protein Binding Gastric Inhibitory Polypeptide Receptor Binding Glucagon Receptor Binding Identical Protein Binding Receptor Ligand Activity
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cellular Response To Glucagon Stimulus	Gluconeogenesis G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Feeding Behavior Protein Kinase A Signaling Response To Activity Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of Gluconeogenesis Regulation Of Insulin Secretion Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucagon Stimulus Positive Regulation Of Calcium Ion Import Negative Regulation Of Execution Phase Of Apoptosis
Pathways		G alpha (s) signalling events Glucagon-type ligand receptors	Glucagon signaling in metabolic regulation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) G alpha (q) signalling events G alpha (s) signalling events Glucagon-type ligand receptors Synthesis, secretion, and deacylation of Ghrelin
Drugs		Glucagon Teduglutide
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) GIP levels in response to oral glucose tolerance test (fasting) ( 29093273) Iron status biomarkers (ferritin levels) ( 33536631) Type 2 diabetes ( 28566273 30297969)	Regular attendance at a pub or social club ( 29970889)
Interacting Genes		3 interacting genes: CALM1 GCG TRIM54	7 interacting genes: CPE CTSL GCGR GLP1R GLP2R MEP1A MEP1B
Entrez ID		9340	2641
HPRD ID		04713	00676
Ensembl ID		ENSG00000065325	ENSG00000115263
Uniprot IDs		A0A384MTS7 B2RAN4 O95838	P01275
PDB IDs		7D68	1BH0 1D0R 1NAU 2G49 2L63 2L64 2M5P 2M5Q 3IOL 4APD 4ZGM 5OTU 5OTV 5OTW 5OTX 5VAI 5YQZ 6EDS 6LMK 6LML 6NZN 6PHI 6PHJ 6PHK 6PHL 6PHO 6PHP 6VCB 6X18 7D68 7DUQ 7KI0 7KI1 7XM8 8ANJ 8ANK 8JRV 9IVG
Enriched GO Terms of Interacting Partners?		Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Calcium Ion Transport Regulation Of Metal Ion Transport Glucagon Receptor Binding Gastric Inhibitory Polypeptide Receptor Binding Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Execution Phase Of Apoptosis Regulation Of Monoatomic Ion Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cellular Response To Glucagon Stimulus Titin Binding Protein Kinase A Signaling Regulation Of Voltage-gated Calcium Channel Activity Detection Of Calcium Ion Calcium Channel Inhibitor Activity Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Calyx Of Held Response To Glucagon Negative Regulation Of Transporter Activity Cellular Response To Interferon-beta Catalytic Complex Presynaptic Cytosol Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Cell Action Potential Calcineurin-mediated Signaling Positive Regulation Of Calcium Ion Import Positive Regulation Of Gluconeogenesis Myelin Sheath Negative Regulation Of Microtubule Depolymerization G Protein-coupled Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Response To Interferon-beta Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Microtubule Depolymerization Microtubule Associated Complex Negative Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT	Glucagon Receptor Activity Cellular Response To Glucagon Stimulus Response To Glucagon Meprin A Complex Peptide Hormone Processing Peptide Hormone Binding Signaling Receptor Ligand Precursor Processing Cellular Response To Hormone Stimulus Metallopeptidase Activity Peptidase Activity Regulation Of Hormone Levels Protein Processing Cellular Response To Peptide Hormone Stimulus Hormone Metabolic Process Response To Hormone Transmembrane Signaling Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Response To Peptide Hormone Protein Maturation Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Glucagon-like Peptide 1 Receptor Activity Plasma Membrane G Protein-coupled Receptor Activity Hormone Secretion Metalloendopeptidase Activity Enkephalin Processing Epidermal Growth Factor Receptor Ligand Maturation Hormone Transport Proteolysis Protein Localization To Secretory Granule Macrophage Apoptotic Process Elastin Catabolic Process Fusion Of Virus Membrane With Host Plasma Membrane Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Ribonucleoside-diphosphate Reductase Complex Chromaffin Granule Elastin Metabolic Process Endolysosome Lumen Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Psychosocial Stress Signal Release Regulation Of Blood Pressure Inflammatory Cell Apoptotic Process Extracellular Space Regulation Of Biological Quality Ferric Iron Binding Post-translational Protein Targeting To Membrane, Translocation Metallodipeptidase Activity
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