GLP2R and GCG

Number of citations of the paper that reports this interaction (PMID 11738243)
6

Data Source:
HPRD (in vivo, in vitro)

		GLP2R	GCG
Gene Name		glucagon-like peptide 2 receptor	glucagon
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Secretory Granule Lumen
	Molecular Function	G-protein Coupled Receptor Activity Glucagon Receptor Activity	Receptor Binding Hormone Activity Protein Binding Glucagon Receptor Binding Identical Protein Binding
	Biological Process	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Cellular Response To Glucagon Stimulus	Energy Reserve Metabolic Process Signal Transduction G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Feeding Behavior Cell Proliferation Protein Kinase A Signaling Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Starvation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Regulation Of Insulin Secretion Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucagon Stimulus Positive Regulation Of Calcium Ion Import Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Synthesis, secretion, and deacylation of Ghrelin Integration of energy metabolism G alpha (s) signalling events Regulation of insulin secretion Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events Peptide hormone metabolism GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class B/2 (Secretin family receptors) Glucagon signaling in metabolic regulation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: CALM1 GCG	7 interactors: CPE CTSL GCGR GLP1R GLP2R MEP1A MEP1B
Entrez ID		9340	2641
HPRD ID		04713	00676
Ensembl ID			ENSG00000115263
Uniprot IDs		O95838	P01275
PDB IDs			1BH0 1D0R 1NAU 2G49 2L63 2L64 2M5P 2M5Q 3IOL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Positive Regulation Of Calcium Ion Transport Regulation Of CAMP Metabolic Process Energy Reserve Metabolic Process Regulation Of Calcium Ion Transport Positive Regulation Of Ion Transport Energy Derivation By Oxidation Of Organic Compounds Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Generation Of Precursor Metabolites And Energy Regulation Of Ion Transmembrane Transport Regulation Of High Voltage-gated Calcium Channel Activity Protein Kinase A Signaling Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transferase Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Execution Phase Of Apoptosis Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ion Transport Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Protein Phosphorylation Detection Of Calcium Ion Positive Regulation Of Transport Regulation Of Protein Kinase Activity Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Kinase Activity Positive Regulation Of Calcium Ion Import Response To Organonitrogen Compound Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Protein Modification Process Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Gluconeogenesis Regulation Of Voltage-gated Calcium Channel Activity	Cellular Response To Glucagon Stimulus Response To Glucagon Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Response To Hormone Cellular Response To Peptide G-protein Coupled Receptor Signaling Pathway Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Digestion Proteolysis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Macrophage Apoptotic Process Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Organic Substance Response To Organonitrogen Compound Insulin Processing Myeloid Cell Apoptotic Process Inflammatory Cell Apoptotic Process Insulin Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Thyroid Hormone Stimulus Response To Organic Substance Cardiac Left Ventricle Morphogenesis Response To Thyroid Hormone Generation Of Precursor Metabolites And Energy CAMP-mediated Signaling Signal Transduction Cell Surface Receptor Signaling Pathway Response To Stimulus Activation Of Adenylate Cyclase Activity Cyclic-nucleotide-mediated Signaling Peptide Hormone Processing Signaling Response To Stress Positive Regulation Of Adenylate Cyclase Activity Cell Communication Regulation Of Glycogen Metabolic Process Toxin Transport
Tagcloud ?		adaptation adaptive atrophy bowel crypt deprivation erbb exerts fasted fasting glucagon gut height histomorphometry igfr intestinal intestine jejunal kgf mucosal nutrients pan refed refeeding trophic undergoes villus weights	abolishing ascribe cac carboxylate carboxylcytosine charged conflicts cytosine differently egr1 electrostatic favorably fc finger formylcytosine gggcg glutamine hmc hydroxymethylcytosine mc methylcytosine oxidized splice unmethylated unmodified unoxidized ways wilms wt1
Tagcloud (Difference) ?		adaptation adaptive atrophy bowel crypt deprivation erbb exerts fasted fasting glucagon gut height histomorphometry igfr intestinal intestine jejunal kgf mucosal nutrients pan refed refeeding trophic undergoes villus weights	abolishing ascribe cac carboxylate carboxylcytosine charged conflicts cytosine differently egr1 electrostatic favorably fc finger formylcytosine gggcg glutamine hmc hydroxymethylcytosine mc methylcytosine oxidized splice unmethylated unmodified unoxidized ways wilms wt1
Tagcloud (Intersection) ?