ST6GAL1

Name	ST6 beta-galactoside alpha-2,6-sialyltransferase 1
Structure
Novel Interactors	1 novel interactors: NAT8
Interactors	1 interactors: CD22
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Golgi Apparatus Membrane Golgi Cisterna Membrane
	Molecular Function	Beta-galactoside Alpha-2,6-sialyltransferase Activity Protein Binding Sialyltransferase Activity Transferase Activity Glycosyltransferase Activity Protein Homodimerization Activity
	Biological Process	N-acetylneuraminate Metabolic Process Protein Glycosylation Protein O-linked Glycosylation Via N-acetyl-galactosamine Protein N-linked Glycosylation Via Asparagine Viral Protein Processing Sialylation
Pathways	Sialic acid metabolism Maturation of protein 3a Maturation of spike protein Maturation of protein 3a N-Glycan antennae elongation Termination of O-glycan biosynthesis
GWAS	Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309 ) Albumin-globulin ratio ( 29403010 ) Drug-induced liver injury (flucloxacillin) ( 19483685 ) Eosinophil percentage of white cells ( 32888494 ) Esophageal cancer (squamous cell) ( 22960999 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) IgA nephropathy ( 26028593 ) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392 ) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392 ) IgG disialylation phenotypes (multivariate analysis) ( 28878392 ) IgG fucosylation phenotypes (multivariate analysis) ( 28878392 ) IgG galactosylation phenotypes (multivariate analysis) ( 28878392 ) IgG glycosylation ( 23382691 ) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392 ) IgG monosialylation phenotypes (multivariate analysis) ( 28878392 ) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391 ) IgG sialylation phenotypes (multivariate analysis) ( 28878392 ) Immature fraction of reticulocytes ( 32888494 ) N-glycan levels ( 31163085 ) Non-albumin protein levels ( 29403010 ) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132 ) Thyroglobulin plasma levels ( 30929638 ) Type 2 diabetes ( 30718926 30297969 32499647 30054458 21874001 )
Entrez ID	6480
HPRD ID	00184
Ensembl ID	ENSG00000073849
Uniprot IDs	P15907
PDB IDs	4JS1 4JS2 6QVS 6QVT
GO Terms Enriched among Interactors ?	Peptidyl-lysine N6-acetylation L-cysteine-S-conjugate N-acetyltransferase Activity IgM Binding CD4 Receptor Binding Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Immunoglobulin Production Internal Protein Amino Acid Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor N-acetyltransferase Activity Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Calcium-mediated Signaling Neuronal Cell Body Membrane Sialic Acid Binding Protein-lysine-acetyltransferase Activity Amyloid Fibril Formation Protein Acetylation Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Glutathione Metabolic Process Regulation Of B Cell Proliferation Regulation Of Immunoglobulin Production Endoplasmic Reticulum-Golgi Intermediate Compartment Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Protein Phosphatase Binding Regulation Of Calcium-mediated Signaling