ST6GAL1

Gene Name		ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Integral Component Of Golgi Membrane Golgi Cisterna Membrane Extracellular Vesicular Exosome
	Molecular Function	Beta-galactoside Alpha-2,6-sialyltransferase Activity Sialyltransferase Activity
	Biological Process	N-acetylneuraminate Metabolic Process Dolichol-linked Oligosaccharide Biosynthetic Process Protein O-linked Glycosylation Humoral Immune Response O-glycan Processing Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process Sialylation
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Transport to the Golgi and subsequent modification Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) O-linked glycosylation N-Glycan antennae elongation Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein N-glycan antennae elongation in the medial/trans-Golgi Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Termination of O-glycan biosynthesis Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) O-linked glycosylation of mucins Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS		Drug-induced liver injury (flucloxacillin) ( 19483685) Esophageal cancer (squamous cell) ( 22960999) IgG glycosylation ( 23382691) Type 2 diabetes ( 21874001)
Protein-protein Interactions		1 interactors: CD22
Entrez ID		6480
HPRD ID		00184
Ensembl ID		ENSG00000073849
Uniprot IDs		B2R513 P15907
PDB IDs		4JS1 4JS2
Enriched GO Terms of Interacting Partners?
Tagcloud ?		aberrantly accumulating atlas bladder catalyzes characterizes demethylation galactose invasive invasiveness irs j82 merthylation msp nu papillary portal posttranslational pt2 pta rt112 rt4 sialic suppressive tcga unmethylated urothelium urotsa verified