POLR3F and BRF1

Number of citations: 0 (PubMedID 9171375)
Data Source: HPRD (in vitro, in vivo)

		POLR3F	BRF1
Name		RNA polymerase III subunit F	BRF1 general transcription factor IIIB subunit
Structure			No pdb structure
GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase III Complex Cytoplasm Cytosol	Transcription Factor TFIIIB Complex Nucleus Nucleoplasm Transcription Preinitiation Complex
	Molecular Function	DNA Binding Double-stranded DNA Binding DNA-directed RNA Polymerase Activity Protein Binding 4 Iron, 4 Sulfur Cluster Binding	RNA Polymerase III General Transcription Initiation Factor Activity RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding Protein Binding Zinc Ion Binding TBP-class Protein Binding Metal Ion Binding
	Biological Process	Immune System Process Regulation Of Transcription By RNA Polymerase III Transcription By RNA Polymerase III Positive Regulation Of Interferon-beta Production Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus	DNA-templated Transcription Initiation Transcription By RNA Polymerase III Transcription Initiation At RNA Polymerase III Promoter RRNA Transcription TRNA Transcription Transcription Preinitiation Complex Assembly
Pathways		Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter	RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter
GWAS		Refractive error ( 32231278 )	Huntington's disease progression ( 28642124 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean platelet volume ( 22139419 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Platelet count ( 27863252 29403010 32888494 ) Platelet distribution width ( 27863252 ) Red blood cell count ( 32888494 )
Novel Interactors		1 novel interactors: NINL	None recorded
Interacting Genes		15 interacting genes: ATPAF2 BDP1 BRF1 ERG28 GTF3C4 KAT5 LRIF1 PRP4K RIN3 STC2 SUV39H2 TBP TNS2 UBE2G2 WDR89	16 interacting genes: APP CSNK2A1 DTNBP1 GTF3C3 GTF3C4 GTF3C5 PCBD2 POLR3F RB1 RBL1 RBL2 RHOU RLIM TBP TP53 UBC
Entrez ID		10621	2972
HPRD ID		15156	05361
Ensembl ID		ENSG00000132664	ENSG00000185024
Uniprot IDs		A0A8V8TL53 A0A8V8TMS0 Q05DB8 Q9H1D9	Q92994 V9HVY2
PDB IDs		2DK5 2YU3 7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS	Not available
GO Terms Enriched among Interactors		RNA Polymerase III General Transcription Initiation Factor Activity Transcription By RNA Polymerase III Transcription Factor TFIIIB Complex Transcription Initiation At RNA Polymerase III Promoter Transcription Preinitiation Complex Assembly TRNA Transcription DNA-templated Transcription Initiation RRNA Transcription Protein-lysine-acetyltransferase Activity Histone Acetyltransferase Activity Chromosome, Centromeric Region Protein-DNA Complex Assembly Histone H2AK5 Acetyltransferase Activity RNA Polymerase III Preinitiation Complex Assembly Negative Regulation Of Mast Cell Chemotaxis	Transcription By RNA Polymerase III RNA Polymerase III General Transcription Initiation Factor Activity Regulation Of Lipid Kinase Activity RRNA Transcription Transcription Factor TFIIIC Complex 5S Class RRNA Transcription By RNA Polymerase III DNA-templated Transcription TRNA Transcription By RNA Polymerase III TRNA Transcription Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Chromatin Organization Nucleobase-containing Compound Biosynthetic Process Glial Cell Apoptotic Process RNA Metabolic Process Negative Regulation Of Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm Transcription Initiation At RNA Polymerase III Promoter Regulation Of Cell Cycle G1/S Phase Transition DNA Binding Negative Regulation Of Gene Expression Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Promoter-specific Chromatin Binding DNA-templated Transcription Initiation Nucleus Transcription Regulator Complex RRNA Metabolic Process Regulation Of Mitotic Cell Cycle Epigenetic Regulation Of Gene Expression Regulation Of DNA-templated Transcription Negative Regulation Of Glial Cell Proliferation Regulation Of RNA Biosynthetic Process Core Promoter Sequence-specific DNA Binding Regulation Of Phosphorus Metabolic Process PML Body Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of RNA Metabolic Process Molecular Function Activator Activity Chromatin Remodeling Regulation Of Cell Cycle Disordered Domain Specific Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Receptor Internalization