MBNL1 and RPL21

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		MBNL1	RPL21
Description		muscleblind like splicing regulator 1	ribosomal protein L21
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule	Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse Ribonucleoprotein Complex
	Molecular Function	RNA Binding Double-stranded RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	In Utero Embryonic Development MRNA Processing Nervous System Development RNA Splicing Embryonic Limb Morphogenesis Regulation Of RNA Splicing Myoblast Differentiation	Cytoplasmic Translation Translation
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Blond vs. brown/black hair color ( 30531825) End-stage renal disease ( 29885931) Fasting glucose ( 34059833) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Infantile hypertrophic pyloric stenosis ( 22306654) Liver enzyme levels (alanine transaminase) ( 33972514) Male-pattern baldness ( 27182965) Prostate cancer ( 29892016) Type 2 diabetes ( 30054458 30297969 32499647) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) White blood cell count ( 32888494)	Aspartate aminotransferase levels ( 33547301) Electrocardiographic traits ( 17903306) Estimated glomerular filtration rate ( 31451708)
Interacting Genes		21 interacting genes: ABI3BP AEN APP BCAS2 BIN1 CEBPA DAB1 DMRTB1 FBXO7 IDH3A ITSN2 PKM PRPF39 QKI RBFOX2 RBPMS RPL21 SNRPA TLE5 UBC ZNHIT3	7 interacting genes: DUX4 EXOSC7 HNRNPA1 MBNL1 PIM2 PTEN VHL
Entrez ID		4154	6144
HPRD ID		07355	04700
Ensembl ID		ENSG00000152601	ENSG00000122026
Uniprot IDs		A0A0A0MQX8 C9JP00 Q86VM6 Q9NR56	P46778 Q6IAX2
PDB IDs		3D2N 3D2Q 3D2S 5U6H 5U6L 5U9B	4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Regulation Of Astrocyte Differentiation RNA Processing Nucleus RNA Splicing Regulation Of Glial Cell Differentiation Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Gliogenesis MRNA Binding MRNA Processing U1 SnRNP Negative Regulation Of Cell Development Negative Regulation Of Blood Circulation Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Hemopoiesis Positive Regulation Of Glial Cell Differentiation Synaptic Vesicle Endocytosis Lipid Tube Positive Regulation Of Developmental Process Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway RNA Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Nucleic Acid Binding MRNA Metabolic Process Regulation Of MRNA Processing Internal N(7)-methylguanine-containing RNA Reader Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Presynaptic Endocytosis Vesicle Dendrite Development Macrophage Differentiation Regulation Of RNA Splicing Regulation Of Neuron Differentiation RNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Amyloid Precursor Protein Catabolic Process Lipid Tube Assembly Negative Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Multicellular Organismal Process Acetylcholine Receptor Activator Activity Lipoprotein Particle	Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Cell Population Proliferation Protein Stabilization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Protein Stability Nucleoplasm Telomeric Repeat-containing RNA Binding Regulation Of Metabolic Process Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Macromolecule Biosynthetic Process Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Positive Regulation Of Biosynthetic Process Regulation Of RNA Splicing Cytoplasm Regulation Of Primary Metabolic Process Response To Sodium Arsenite Cellular Response To Salt Macromolecule Metabolic Process Cellular Response To Sodium Arsenite MRNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Regulation Of Cell Population Proliferation Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Postsynaptic Density Assembly Positive Regulation Of DNA-templated Transcription Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Negative Regulation Of G0 To G1 Transition Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process RNA Processing G-rich Strand Telomeric DNA Binding
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