CD72 and ATP6AP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CD72	ATP6AP2
Description		CD72 molecule	ATPase H+ transporting accessory protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V0 Domain Autophagosome Membrane Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Membrane Vacuolar Proton-transporting V-type ATPase Complex Axon Clathrin-coated Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Dendritic Spine Membrane Proton-transporting V-type ATPase Complex Cell Projection Synapse Postsynaptic Membrane Extracellular Exosome Tertiary Granule Membrane Bounding Membrane Of Organelle Ficolin-1-rich Granule Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding Carbohydrate Binding	Protein Binding Signaling Receptor Activity
	Biological Process	Cell Adhesion Negative Regulation Of B Cell Receptor Signaling Pathway	Angiotensin Maturation Vacuolar Acidification Lysosomal Lumen Acidification Central Nervous System Maturation Rostrocaudal Neural Tube Patterning Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta1 Production Regulation Of MAPK Cascade Eye Pigmentation Endosomal Lumen Acidification Intracellular PH Reduction Head Morphogenesis Golgi Lumen Acidification Positive Regulation Of Canonical Wnt Signaling Pathway Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways		Other semaphorin interactions	Metabolism of Angiotensinogen to Angiotensins Neutrophil degranulation
Drugs
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Blood protein levels ( 30072576) Electroencephalogram traits ( 25387704)	Metabolite levels ( 23823483)
Interacting Genes		22 interacting genes: ATP6AP2 BIK BLNK CD5 CGRRF1 CLDN7 CREB3L1 GPR152 GRAMD1C GRB2 LHFPL5 LMNA LRRC25 LSMEM2 LYN MS4A3 MS4A7 NRG1 PTPN6 SEMA4D SPACA1 SYK	20 interacting genes: ADRA1A AGT CD72 CREB3 GLP1R HTR2C NINJ1 NKG7 NSG1 PMP22 PTTG1IP REN SEC22A TIMMDC1 TMEM203 TMEM97 UPK2 VAMP5 VKORC1 ZBTB16
Entrez ID		971	10159
HPRD ID		00118	06454
Ensembl ID		ENSG00000137101	ENSG00000182220
Uniprot IDs		P21854 Q5TLG3	O75787
PDB IDs			3LBS 3LC8 6WLW 6WM2 6WM3 6WM4 7U4T
Enriched GO Terms of Interacting Partners?		B Cell Receptor Signaling Pathway T Cell Costimulation Membrane Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Adhesion Phosphotyrosine Residue Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin SH2 Domain Binding Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Plasma Membrane Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Immune Response-activating Signaling Pathway Phosphorylation-dependent Protein Binding Negative Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Activation Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Neutrophil Activation Involved In Immune Response Regulation Of MAPK Cascade Negative Regulation Of Immune Response Immune Response-regulating Signaling Pathway Activation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Lymphocyte Activation Regulation Of Mast Cell Activation Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Phospholipase Binding Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Cellular Component Biogenesis Regulation Of Lymphocyte Activation Regulation Of Cell-cell Adhesion SH3 Domain Binding Negative Regulation Of Defense Response Regulation Of ERK1 And ERK2 Cascade Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Chemorepellent Activity Ephrin Receptor Binding Neutrophil Activation	Type 2 Angiotensin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Membrane Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Blood Volume By Renin-angiotensin Establishment Of Protein Localization To Plasma Membrane Regulation Of Blood Pressure Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Mesonephros Development Angiotensin-activated Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Protein Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Hormone Levels Cell-cell Signaling Blood Vessel Diameter Maintenance Vasoconstriction Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Cell Communication Regulation Of Tube Size Regulation Of System Process Signaling CGMP-mediated Signaling Kidney Development Regulation Of Lipid Transport Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Golgi To Plasma Membrane Protein Transport Vesicle-mediated Transport To The Plasma Membrane Intracellular Protein Localization Establishment Of Protein Localization Glucagon-like Peptide 1 Receptor Activity Regulation Of Monocyte Chemotaxis Ferroptosis Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Deacetylase Activity Postsynaptic Neurotransmitter Receptor Cycle Neurotransmitter Receptor Cycle Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Positive Regulation Of Inflammatory Response Animal Organ Development Regulation Of Systemic Arterial Blood Pressure Signaling Receptor Binding Protein Localization To Plasma Membrane Regulation Of Heart Contraction Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Phospholipase C-activating Adrenergic Receptor Signaling Pathway Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
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