DLD and OGDH

Number of citations of the paper that reports this interaction (PubMedID 9727038)
0

Data Source:
HPRD (in vitro)

		DLD	OGDH
Description		dihydrolipoamide dehydrogenase	oxoglutarate dehydrogenase
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GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cilium Cytoplasmic Vesicle Motile Cilium Cell Projection Acrosomal Matrix Oxoglutarate Dehydrogenase Complex Pyruvate Dehydrogenase Complex Branched-chain Alpha-ketoacid Dehydrogenase Complex Oxoadipate Dehydrogenase Complex Acetyltransferase Complex	Nucleus Mitochondrion Mitochondrial Matrix Mitochondrial Membrane Oxoglutarate Dehydrogenase Complex
	Molecular Function	Dihydrolipoyl Dehydrogenase (NADH) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, NAD(P) As Acceptor Flavin Adenine Dinucleotide Binding	Oxoglutarate Dehydrogenase (succinyl-transferring) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors Thiamine Pyrophosphate Binding Heat Shock Protein Binding Metal Ion Binding Protein-folding Chaperone Binding
	Biological Process	Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Metabolic Process 2-oxoglutarate Metabolic Process Mitochondrial Electron Transport, NADH To Ubiquinone Proteolysis Gastrulation Branched-chain Amino Acid Catabolic Process Regulation Of Membrane Potential Sperm Capacitation 2-oxoglutarate Decarboxylation To Succinyl-CoA Branched-chain Alpha-keto Acid Decarboxylation To Branched-chain Acyl-CoA	Generation Of Precursor Metabolites And Energy Glycolytic Process Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process NAD+ Metabolic Process Cerebellar Cortex Development Striatum Development Hippocampus Development Thalamus Development Pyramidal Neuron Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Olfactory Bulb Mitral Cell Layer Development
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Glycine degradation Branched-chain amino acid catabolism Mitochondrial protein degradation OGDH complex synthesizes succinyl-CoA from 2-OG OADH complex synthesizes glutaryl-CoA from 2-OA BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV PDH complex synthesizes acetyl-CoA from PYR Loss-of-function mutations in DBT cause MSUD2 Loss-of-function mutations in DLD cause MSUD3/DLDD Branched-chain ketoacid dehydrogenase kinase deficiency H139Hfs13* PPM1K causes a mild variant of MSUD	Glycine degradation Mitochondrial protein degradation OGDH complex synthesizes succinyl-CoA from 2-OG
Drugs		NADH Flavin adenine dinucleotide	NADH Valproic acid Xanthinol
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome Maple syrup urine disease (MSUD)	Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency
GWAS		Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 19122664 20228799 23128233 28067908) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Femur bone mineral density x serum urate levels interaction ( 34046847) Low density lipoprotein cholesterol levels ( 32154731) Lung cancer in never smokers ( 28604730) Systolic blood pressure change trajectory ( 27980656)
Interacting Genes		5 interacting genes: ITGB1BP1 OGDH OGT PDHX SLC2A4	6 interacting genes: ANXA2 DLD DLST HSD17B10 PLSCR1 USP7
Entrez ID		1738	4967
HPRD ID		02006	08938
Ensembl ID		ENSG00000091140	ENSG00000105953
Uniprot IDs		A0A024R713 E9PEX6 P09622	A0A140VJQ5 B4DH65 B4E3E9 E9PCR7 E9PDF2 Q02218
PDB IDs		1ZMC 1ZMD 1ZY8 2F5Z 3RNM 5J5Z 5NHG 6HG8 6I4P 6I4Q 6I4R 6I4S 6I4T 6I4U 6I4Z 7PSC 7ZYT	3ERY 7WGR 8I0K
Enriched GO Terms of Interacting Partners?		Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors Pyruvate Metabolic Process Acyl-CoA Metabolic Process Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Olfactory Bulb Mitral Cell Layer Development Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Dihydrolipoyllysine-residue Acetyltransferase Activity Mitochondrial Membrane Thiamine Pyrophosphate Binding Carbohydrate Derivative Metabolic Process Pyramidal Neuron Development Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor Tangential Migration From The Subventricular Zone To The Olfactory Bulb Sulfur Compound Metabolic Process Oxoglutarate Dehydrogenase Complex Oxoglutarate Dehydrogenase (succinyl-transferring) Activity Cerebellar Cortex Development Insulin-responsive Compartment Carbohydrate Homeostasis Dehydroascorbic Acid Transport Glucose Import In Response To Insulin Stimulus Glucose Homeostasis Vascular Process In Circulatory System Response To Insulin White Fat Cell Proliferation Fat Cell Proliferation Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Dehydrogenase Complex Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Regulation Of Cell Junction Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Activation Of Protein Kinase B Activity Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Negative Regulation Of Protein Targeting To Membrane Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Transcription By Glucose Succinyl-CoA Metabolic Process D-glucose Transmembrane Transporter Activity Thalamus Development Response To Peptide Hormone NSL Complex Integrin Activation	Oxoadipate Dehydrogenase Complex Oxoglutarate Dehydrogenase Complex Succinyl-CoA Metabolic Process Amino Acid Catabolic Process 2-oxoglutarate Metabolic Process Branched-chain Amino Acid Catabolic Process Branched-chain Amino Acid Metabolic Process Acetyl-CoA Metabolic Process Carboxylic Acid Catabolic Process Amino Acid Metabolic Process Aspartate Family Amino Acid Metabolic Process Negative Regulation Of Endocytosis Dihydrolipoyl Dehydrogenase (NADH) Activity 2-oxoglutarate Decarboxylation To Succinyl-CoA Acetyltransferase Complex Dihydrolipoyllysine-residue Succinyltransferase Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Mitochondrial Matrix Proteinogenic Amino Acid Catabolic Process L-amino Acid Catabolic Process Serine-type Endopeptidase Inhibitor Activity Acyl-CoA Metabolic Process Dicarboxylic Acid Metabolic Process Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport AnxA2-p11 Complex PCSK9-AnxA2 Complex Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Succinyl-CoA Biosynthetic Process 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Lead Ion Binding Positive Regulation Of Platelet-derived Growth Factor Production Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Receptor Catabolic Process Positive Regulation Of Intracellular Cholesterol Transport Regulation Of Vesicle-mediated Transport Acrosomal Matrix L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Phosphatidylserine Biosynthetic Process Mercury Ion Binding Phosphatidylserine Exposure On Apoptotic Cell Surface
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