DLD and SLC2A4

Number of citations of the paper that reports this interaction (PMID 16396496)
24

Data Source:
HPRD (in vivo)

		DLD	SLC2A4
Gene Name		dihydrolipoamide dehydrogenase	solute carrier family 2 (facilitated glucose transporter), member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cilium Acrosomal Matrix	Multivesicular Body Cytosol Plasma Membrane Integral Component Of Plasma Membrane Coated Pit External Side Of Plasma Membrane Endomembrane System Vesicle Membrane Membrane Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle T-tubule Insulin-responsive Compartment Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Dihydrolipoyl Dehydrogenase Activity Mercury (II) Reductase Activity Mercury Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding	Glucose Transmembrane Transporter Activity Protein Binding D-glucose Transmembrane Transporter Activity
	Biological Process	Pyruvate Metabolic Process Tricarboxylic Acid Cycle Mitochondrial Electron Transport, NADH To Ubiquinone Proteolysis Lysine Catabolic Process Gastrulation Branched-chain Amino Acid Catabolic Process Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Nitrogen Compound Metabolic Process Regulation Of Membrane Potential Cellular Metabolic Process Small Molecule Metabolic Process Cell Redox Homeostasis Sperm Capacitation Detoxification Of Mercury Ion	Carbohydrate Metabolic Process Hexose Transport Pathogenesis Amylopectin Biosynthetic Process Glucose Transport Cellular Response To Insulin Stimulus Glucose Homeostasis Small Molecule Metabolic Process Response To Ethanol Glucose Import Brown Fat Cell Differentiation Transmembrane Transport Membrane Organization Cellular Response To Hypoxia Cellular Response To Osmotic Stress
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Branched-chain amino acid catabolism Signaling by Retinoic Acid Lysine catabolism Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Metabolism of amino acids and derivatives Citric acid cycle (TCA cycle)	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Translocation of GLUT4 to the plasma membrane SLC-mediated transmembrane transport Hexose transport Myoclonic epilepsy of Lafora Transcriptional regulation of white adipocyte differentiation Facilitative Na+-independent glucose transporters Glycogen storage diseases Glucose transport Metabolism of carbohydrates
Drugs		NADH Nicotinamide-Adenine-Dinucleotide Flavin-Adenine Dinucleotide
Diseases
GWAS		Ulcerative colitis ( 23128233 20228799 19122664)	Birth weight ( 23202124) Metabolite levels ( 22286219)
Protein-Protein Interactions		3 interactors: OGDH PDHX SLC2A4	38 interactors: ACOX1 ACTN1 ACTN4 AKT2 ARF3 ARFIP1 BSG C1QTNF5 CCDC116 CFL1 CTSD DAXX DLD EHD2 ESYT2 FAR1 FKBP10 GAPDH HADH HK2 HSP90AA1 IDH2 KLHL41 LNPEP MAP1S MVP P3H1 P3H4 PDIA6 PRKAR1A PSMD7 RAB7A SERPINH1 SRFBP1 STRN3 UBA52 UBE2I UBE2N
Entrez ID		1738	6517
HPRD ID		02006	00688
Ensembl ID		ENSG00000091140	ENSG00000181856
Uniprot IDs		B4DT69 E9PEX6 P09622	P14672 Q05BQ3
PDB IDs		1ZMC 1ZMD 1ZY8 2F5Z 3RNM
Enriched GO Terms of Interacting Partners?		Pyruvate Metabolic Process Amylopectin Biosynthetic Process Olfactory Bulb Mitral Cell Layer Development Succinyl-CoA Metabolic Process Tangential Migration From The Subventricular Zone To The Olfactory Bulb Small Molecule Metabolic Process Lysine Catabolic Process Glucose Import Pyramidal Neuron Development Pyramidal Neuron Differentiation Monocarboxylic Acid Metabolic Process Thalamus Development 2-oxoglutarate Metabolic Process Striatum Development Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate NADH Metabolic Process Regulation Of Acyl-CoA Biosynthetic Process Subpallium Development Hexose Transmembrane Transport Cellular Response To Osmotic Stress Forebrain Neuron Development Tricarboxylic Acid Cycle Olfactory Bulb Development Citrate Metabolic Process Brown Fat Cell Differentiation Carboxylic Acid Metabolic Process Olfactory Lobe Development Carbohydrate Metabolic Process NAD Metabolic Process Tricarboxylic Acid Metabolic Process Organic Acid Metabolic Process Carbohydrate Transmembrane Transport Aerobic Respiration Forebrain Neuron Differentiation Acyl-CoA Metabolic Process Cerebellar Cortex Development Glucose Transport Hippocampus Development Hexose Transport Forebrain Generation Of Neurons Nicotinamide Nucleotide Metabolic Process Regulation Of Fatty Acid Metabolic Process Response To Osmotic Stress Diencephalon Development Dicarboxylic Acid Metabolic Process Glycolytic Process Limbic System Development Cellular Response To Hypoxia Telencephalon Cell Migration Cellular Response To Decreased Oxygen Levels	Generation Of Precursor Metabolites And Energy Catabolic Process Protein Localization To Tight Junction Protein Transport Establishment Of Protein Localization Protein Localization Small Molecule Metabolic Process Organelle Organization Positive Regulation Of Transferase Activity Monocarboxylic Acid Metabolic Process Regulation Of Body Fluid Levels Antigen Processing And Presentation Of Peptide Antigen Protein Targeting Blood Coagulation Hemostasis Pyruvate Metabolic Process Intracellular Protein Transport Oxidation-reduction Process Response To Stress Protein Localization To Cell Junction Glucose Metabolic Process Antigen Processing And Presentation Regulation Of Cellular Protein Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Establishment Of Localization In Cell Protein Polyubiquitination Response To Stimulus Cellular Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Cytoskeleton Organization Protein Localization To Membrane Platelet Degranulation Immune System Process Vesicle-mediated Transport Protein Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Extracellular Matrix Organization Extracellular Structure Organization Collagen Metabolic Process Membrane Organization Actin Cytoskeleton Organization Positive Regulation Of Ligase Activity Intracellular Receptor Signaling Pathway Transport Wound Healing Multicellular Organismal Macromolecule Metabolic Process Protein Metabolic Process Regulation Of Protein Ubiquitination
Tagcloud ?		a25 anisomycin ap b42 calyculin changing cm cotransfection dexamethasone dichloroisocoumarin dithiocarbamate flanking fos heterogenous interferon jak jun microm nitrite nos okadaic oxide panepoxydone phenylarsine pyrrolidine resting stat1alpha tyrphostin unlikely	atp1a2 atp1b2 beef corpus cows diestrus follicle glandular gonadotropin lcl lf luteum manipulated nelore ovulation p4 periovulatory pof preovulatory proestrus receptivity slaughtered slc5a1 washings
Tagcloud (Difference) ?		a25 anisomycin ap b42 calyculin changing cm cotransfection dexamethasone dichloroisocoumarin dithiocarbamate flanking fos heterogenous interferon jak jun microm nitrite nos okadaic oxide panepoxydone phenylarsine pyrrolidine resting stat1alpha tyrphostin unlikely	atp1a2 atp1b2 beef corpus cows diestrus follicle glandular gonadotropin lcl lf luteum manipulated nelore ovulation p4 periovulatory pof preovulatory proestrus receptivity slaughtered slc5a1 washings
Tagcloud (Intersection) ?