BMP5 and CHRDL2

Number of citations of the paper that reports this interaction (PMID 14660436)
14

Data Source:
HPRD (in vivo)

		BMP5	CHRDL2
Gene Name		bone morphogenetic protein 5	chordin-like 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Extracellular Space Membrane-bounded Vesicle	Extracellular Space Cytoplasm
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity BMP Receptor Binding
	Biological Process	Skeletal System Development Ossification Type B Pancreatic Cell Development Pattern Specification Process Negative Regulation Of Cell Proliferation Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Steroid Biosynthetic Process BMP Signaling Pathway Male Genitalia Development Negative Regulation Of Aldosterone Biosynthetic Process Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Epithelial Cell Proliferation Cartilage Development SMAD Protein Signal Transduction Negative Regulation Of Mononuclear Cell Migration Positive Regulation Of Dendrite Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cortisol Biosynthetic Process Positive Regulation Of DNA-dependent DNA Replication	Ossification Cell Differentiation Negative Regulation Of BMP Signaling Pathway Cartilage Development
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: BMPR1A CHRDL2 FST NOG	7 interactors: BMP2 BMP4 BMP5 BMP6 BMP7 GDF5 INHBA
Entrez ID		653	25884
HPRD ID		00210	09881
Ensembl ID		ENSG00000112175	ENSG00000054938
Uniprot IDs		B4E0Y4 M9VUD0 P22003	Q6WN34
PDB IDs
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway Skeletal System Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cartilage Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Negative Regulation Of BMP Signaling Pathway Organ Formation Tissue Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Pituitary Gland Development Pattern Specification Process Embryonic Digit Morphogenesis Regulation Of BMP Signaling Pathway Endoderm Development Mesoderm Formation Tissue Morphogenesis Diencephalon Development Mesoderm Morphogenesis Somite Development Developmental Process Involved In Reproduction Negative Regulation Of Cell Differentiation Odontogenesis Of Dentin-containing Tooth Mesenchymal Cell Development Dorsal/ventral Pattern Formation Neural Plate Mediolateral Regionalization Negative Regulation Of Cytokine Activity Paraxial Mesoderm Structural Organization Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Regulation Of Osteoblast Differentiation Formation Of Primary Germ Layer Odontogenesis Regulation Of Signal Transduction Mesenchymal Cell Differentiation Enzyme Linked Receptor Protein Signaling Pathway Mesoderm Development Stem Cell Maintenance Positive Regulation Of Epithelial Cell Proliferation Organ Development Embryonic Limb Morphogenesis Organ Morphogenesis Regulation Of Signaling Limb Morphogenesis Regulation Of Organ Morphogenesis Epithelium Development Negative Regulation Of Signal Transduction Gastrulation Regulation Of Ossification Limb Development Mesenchyme Development	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Growth Cartilage Development Connective Tissue Development Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Neurogenesis Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Cartilage Development Regulation Of Protein Phosphorylation Glandular Epithelial Cell Differentiation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Development Regulation Of Neuron Differentiation Positive Regulation Of Protein Metabolic Process Skeletal System Development Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Proliferation Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Cell Proliferation Involved In Kidney Development Ossification Regulation Of Neurogenesis Regulation Of Epithelial Cell Proliferation Regulation Of Cell Death Regulation Of Cell Differentiation Regulation Of Cartilage Development Mesenchymal Cell Proliferation Positive Regulation Of DNA-dependent DNA Replication Positive Regulation Of Ossification Tissue Development Type B Pancreatic Cell Development Regulation Of Intracellular Signal Transduction Regulation Of Cell Development Cell Development Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		abundant adenomatosis apcdd1 bmpr1a closure destinies dictated dkk2 e15 edge eyelid eyelids fetuses fgfr2 gli2 identities ie jag1 lcm le microdissection morphogenetic notch1 opening polyposis ptch1 shh smo tip	affymetrix axin2 bglap2 bmp bridge cooperatively cpz csnk2a1 deformities fgfr1 fibrogenic fzd1 fzd2 groupings hgn id1 lef1 microdissection mmp9 osteogenic plate remodelling repaired sfrp1 sfrp4 spp1 tcf7 wisp1
Tagcloud (Difference) ?		abundant adenomatosis apcdd1 bmpr1a closure destinies dictated dkk2 e15 edge eyelid eyelids fetuses fgfr2 gli2 identities ie jag1 lcm le morphogenetic notch1 opening polyposis ptch1 shh smo tip	affymetrix axin2 bglap2 bmp bridge cooperatively cpz csnk2a1 deformities fgfr1 fibrogenic fzd1 fzd2 groupings hgn id1 lef1 mmp9 osteogenic plate remodelling repaired sfrp1 sfrp4 spp1 tcf7 wisp1
Tagcloud (Intersection) ?		microdissection