BMP5 and BMPR1A

Number of citations of the paper that reports this interaction (PMID 11580864)
12

Data Source:
HPRD (in vivo)

		BMP5	BMPR1A
Gene Name		bone morphogenetic protein 5	bone morphogenetic protein receptor, type IA
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Extracellular Space Membrane-bounded Vesicle	Plasma Membrane Caveola Integral Component Of Membrane Dendrite Neuronal Cell Body
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity BMP Receptor Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding
	Biological Process	Skeletal System Development Ossification Type B Pancreatic Cell Development Pattern Specification Process Negative Regulation Of Cell Proliferation Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Steroid Biosynthetic Process BMP Signaling Pathway Male Genitalia Development Negative Regulation Of Aldosterone Biosynthetic Process Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Epithelial Cell Proliferation Cartilage Development SMAD Protein Signal Transduction Negative Regulation Of Mononuclear Cell Migration Positive Regulation Of Dendrite Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cortisol Biosynthetic Process Positive Regulation Of DNA-dependent DNA Replication	In Utero Embryonic Development Mesoderm Formation Somitogenesis Mullerian Duct Regression Positive Regulation Of Mesenchymal Cell Proliferation Endocardial Cushion Formation Transcription From RNA Polymerase II Promoter Protein Phosphorylation Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Ectoderm Development Dorsal/ventral Axis Specification Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Neural Crest Cell Development Stem Cell Maintenance Pituitary Gland Development Neural Plate Mediolateral Regionalization Signal Transduction By Phosphorylation Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Hindlimb Morphogenesis Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Paraxial Mesoderm Structural Organization Lateral Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Mesendoderm Development Embryonic Organ Development Developmental Growth Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Cartilage Development Palate Development Positive Regulation Of SMAD Protein Import Into Nucleus Heart Formation Regulation Of Cellular Senescence
Pathways			Signaling by BMP
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: BMPR1A CHRDL2 FST NOG	23 interactors: ACVR1 BAMBI BMP2 BMP4 BMP5 BMP6 BMP7 BMPR1B BMPR2 FKBP1A FKBP1B GDF5 GDF6 GDF9 HOXC8 NEDD4 NEDD4L SF3B4 SMAD1 TAB1 TGFBRAP1 USP15 ZMYND11
Entrez ID		653	657
HPRD ID		00210	03192
Ensembl ID		ENSG00000112175
Uniprot IDs		B4E0Y4 M9VUD0 P22003	P36894
PDB IDs			1ES7 1REW 2GOO 2H62 2H64 2K3G 2QJ9 2QJA 2QJB 3NH7 3QB4
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway Skeletal System Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cartilage Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Negative Regulation Of BMP Signaling Pathway Organ Formation Tissue Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Pituitary Gland Development Pattern Specification Process Embryonic Digit Morphogenesis Regulation Of BMP Signaling Pathway Endoderm Development Mesoderm Formation Tissue Morphogenesis Diencephalon Development Mesoderm Morphogenesis Somite Development Developmental Process Involved In Reproduction Negative Regulation Of Cell Differentiation Odontogenesis Of Dentin-containing Tooth Mesenchymal Cell Development Dorsal/ventral Pattern Formation Neural Plate Mediolateral Regionalization Negative Regulation Of Cytokine Activity Paraxial Mesoderm Structural Organization Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Regulation Of Osteoblast Differentiation Formation Of Primary Germ Layer Odontogenesis Regulation Of Signal Transduction Mesenchymal Cell Differentiation Enzyme Linked Receptor Protein Signaling Pathway Mesoderm Development Stem Cell Maintenance Positive Regulation Of Epithelial Cell Proliferation Organ Development Embryonic Limb Morphogenesis Organ Morphogenesis Regulation Of Signaling Limb Morphogenesis Regulation Of Organ Morphogenesis Epithelium Development Negative Regulation Of Signal Transduction Gastrulation Regulation Of Ossification Limb Development Mesenchyme Development	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Signal Transduction Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Cartilage Development Positive Regulation Of Bone Mineralization Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Cartilage Development Cell Surface Receptor Signaling Pathway Regulation Of RNA Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Regulation Of Osteoblast Differentiation Regulation Of Signal Transduction Positive Regulation Of Cell Development Regulation Of Bone Mineralization Positive Regulation Of Protein Metabolic Process Connective Tissue Development Regulation Of Gene Expression Regulation Of Neuron Differentiation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cartilage Development Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Cell Development Regulation Of Phosphorus Metabolic Process Regulation Of Ossification Positive Regulation Of Protein Modification Process Growth Regulation Of Neurogenesis Regulation Of Cell Differentiation Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Response To Organic Substance Skeletal System Development
Tagcloud ?		abundant adenomatosis apcdd1 bmpr1a closure destinies dictated dkk2 e15 edge eyelid eyelids fetuses fgfr2 gli2 identities ie jag1 lcm le microdissection morphogenetic notch1 opening polyposis ptch1 shh smo tip	abundant adenomatosis apcdd1 bmp5 closure destinies dictated dkk2 e15 edge eyelid eyelids fetuses fgfr2 gli2 identities ie jag1 lcm le microdissection morphogenetic notch1 opening polyposis ptch1 shh smo tip
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		abundant adenomatosis apcdd1 bmp5 bmpr1a closure destinies dictated dkk2 e15 edge eyelid eyelids fetuses fgfr2 gli2 identities ie jag1 lcm le microdissection morphogenetic notch1 opening polyposis ptch1 shh smo tip