CD7 and CTSL

Number of citations of the paper that reports this interaction (PubMedID 8666891)
42

Data Source:
HPRD (in vivo)

		CD7	CTSL
Description		CD7 molecule	cathepsin L
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Extracellular Space Nucleus Lysosome Multivesicular Body Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Extracellular Matrix Cytoplasmic Vesicle Endolysosome Lumen Chromaffin Granule Lysosomal Lumen Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Histone Binding Proteoglycan Binding Serpin Family Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Positive Regulation Of T Cell Cytokine Production Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Interleukin-2-mediated Signaling Pathway T Cell Activation	Adaptive Immune Response Proteolysis Protein Autoprocessing Fusion Of Virus Membrane With Host Plasma Membrane Receptor-mediated Endocytosis Of Virus By Host Cell Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Collagen Catabolic Process Zymogen Activation Enkephalin Processing Fusion Of Virus Membrane With Host Endosome Membrane CD4-positive, Alpha-beta T Cell Lineage Commitment Symbiont Entry Into Host Cell Antigen Processing And Presentation Of Peptide Antigen Proteolysis Involved In Protein Catabolic Process Elastin Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus
Pathways			Endosomal/Vacuolar pathway Collagen degradation Degradation of the extracellular matrix Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures HS-GAG degradation MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Attachment and Entry Attachment and Entry Degradation of CDH1
Drugs			L-cysteic acid Felbinac Fostamatinib
Diseases
GWAS		Blood protein levels ( 30072576)
Interacting Genes		9 interacting genes: CPTP CTSL LGALS1 NFKBIA PI4KA PIK3R1 SEC22A SECTM1 SNAP29	29 interacting genes: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 MCPH1 PLAU PPP1CC RELB RSPH1 RXRA SERPINB13 SERPINB3 SGTA SLPI TG
Entrez ID		924	1514
HPRD ID		01732	00293
Ensembl ID		ENSG00000173762	ENSG00000135047
Uniprot IDs		P09564 Q29VG3	P07711 Q5T8F0 Q9HBQ7
PDB IDs			1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM 5F02 5I4H 5MAE 5MAJ 5MQY 6EZP 6EZX 6F06 6JD0 6JD8 7QKB 7QKC 7QKD 7W33 7W34 7Z3T 7Z58 7ZS7 7ZVF 7ZXA 8A4U 8A4V 8A4W 8A4X 8A5B 8AHV 8B4F 8C77 8GX2 8HET 8HFV 8OFA 8OZA 8PRX 8QKB 8UAC
Enriched GO Terms of Interacting Partners?		Membrane Organization Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Plasma Membrane Membrane Fusion Lactose Binding Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cytokine Production Regulation Of Protein Import Into Nucleus Phosphatidylinositol Phosphate Biosynthetic Process Reorganization Of Cellular Membranes To Establish Viral Sites Of Replication SNAP Receptor Activity Macrophage Apoptotic Process Elastin Catabolic Process Fusion Of Virus Membrane With Host Plasma Membrane Immune System Process Chromaffin Granule Enkephalin Processing B Cell Differentiation Regulation Of Immune Response Positive Regulation Of Immune System Process Galectin Complex Receptor Ligand Activity Negative Regulation Of Hemopoiesis Lymphocyte Activation Involved In Immune Response Regulation Of Hemopoiesis Negative Regulation Of Multicellular Organismal Process Cytokine-mediated Signaling Pathway Regulation Of Nucleocytoplasmic Transport Import Into Nucleus Protein Transport Protein Import Into Nucleus I-kappaB/NF-kappaB Complex Negative Regulation Of Myeloid Cell Differentiation Kinase Regulator Activity Perinuclear Endoplasmic Reticulum Membrane Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Metabolic Process 1-phosphatidylinositol 4-kinase Activity Ciliary Pocket Membrane Elastin Metabolic Process Endolysosome Lumen Inflammatory Cell Apoptotic Process Leukocyte Activation Involved In Immune Response Positive Regulation Of Dendritic Cell Differentiation Cell Activation Involved In Immune Response Plasma Cell Differentiation Regulation Of Intracellular Protein Transport Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Establishment Of Protein Localization	Cysteine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Negative Regulation Of Proteolysis Peptidase Inhibitor Activity Regulation Of Proteolysis Extracellular Space Protease Binding Negative Regulation Of Protein Metabolic Process Extracellular Region Endoplasmic Reticulum Lumen Negative Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Metabolic Process Immune Response Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Identical Protein Binding Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Primary Metabolic Process Regulation Of Myelination Extracellular Exosome Regulation Of Macrophage Activation Adaptive Immune Response Negative Regulation Of Endopeptidase Activity Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Peptidase Activity Regulation Of Developmental Process Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Multicellular Organismal Development Positive Regulation Of Proteolysis Regulation Of Microglial Cell Activation Regulation Of Endopeptidase Activity Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of ERAD Pathway Azurophil Granule Lumen Lysosomal Lumen Extracellular Matrix Regulation Of Antigen Processing And Presentation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Nervous System Development Regulation Of ERAD Pathway Regulation Of Viral Life Cycle Positive Regulation Of Granulocyte Chemotaxis Hormone Activity Lymphocyte Mediated Immunity Protein Targeting To ER Negative Regulation Of Protein Catabolic Process
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