SPSB4 and PAWR

Number of citations of the paper that reports this interaction (PMID 20561531)
9

Data Source:
BioGRID (unspecified method)

		SPSB4	PAWR
Gene Name		splA/ryanodine receptor domain and SOCS box containing 4	PRKC, apoptosis, WT1, regulator
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Actin Filament Plasma Membrane Actin Cytoskeleton
	Molecular Function	Protein Binding	Transcription Corepressor Activity Actin Binding Protein Binding Enzyme Binding Leucine Zipper Domain Binding
	Biological Process	Protein Ubiquitination Intracellular Signal Transduction	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Negative Regulation Of Cell Proliferation Negative Regulation Of B Cell Proliferation Interleukin-2 Biosynthetic Process Negative Regulation Of T Cell Proliferation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Apoptotic Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Stroke (ischemic) ( 23041239)	Attention deficit hyperactivity disorder and conduct disorder ( 18951430)
Protein-Protein Interactions		3 interactors: DDX4 NOS2 PAWR	17 interactors: AATF ATP5C1 DAPK3 DRD2 FBXO45 HSPA5 PML PRKCZ RRAS2 SLC5A7 SPSB1 SPSB2 SPSB4 SQSTM1 TFPT THAP1 WT1
Entrez ID		92369	5074
HPRD ID		18108	09051
Ensembl ID		ENSG00000175093
Uniprot IDs		Q96A44	Q96IZ0
PDB IDs		2V24	2JK9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Peptidyl-cysteine S-nitrosylation Interleukin-2 Biosynthetic Process Germ-line Stem Cell Maintenance Regulation Of Amyloid Precursor Protein Biosynthetic Process Interleukin-2 Production Arginine Catabolic Process Positive Regulation Of Killing Of Cells Of Other Organism Regulation Of Killing Of Cells Of Other Organism Positive Regulation Of Guanylate Cyclase Activity Spermatogenesis Male Gamete Generation Regulation Of Cellular Respiration Positive Regulation Of Glycoprotein Biosynthetic Process Nitric Oxide Biosynthetic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Glycoprotein Metabolic Process Nitric Oxide Mediated Signal Transduction Negative Regulation Of B Cell Proliferation Innate Immune Response In Mucosa Positive Regulation Of CGMP Biosynthetic Process Gamete Generation Positive Regulation Of CGMP Metabolic Process Organelle Organization Arginine Metabolic Process Negative Regulation Of T Cell Receptor Signaling Pathway RNA Metabolic Process Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Meiotic Nuclear Division Regulation Of CGMP Biosynthetic Process Cytokine Biosynthetic Process Regulation Of Protein Localization Sexual Reproduction Regulation Of Glycoprotein Biosynthetic Process Multicellular Organismal Reproductive Process Negative Regulation Of Meiotic Cell Cycle Nitric Oxide Metabolic Process Male Meiosis I Multicellular Organism Reproduction Cytokine Metabolic Process Reactive Nitrogen Species Metabolic Process Regulation Of CGMP Metabolic Process Positive Regulation Of Vasodilation Mucosal Immune Response PiRNA Metabolic Process Defense Response To Gram-negative Bacterium Negative Regulation Of B Cell Activation Superoxide Metabolic Process Regulation Of Meiosis Reproduction	Regulation Of Cell Death Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Apoptotic Signaling Pathway Cellular Response To Stimulus Signaling Cell Communication Signal Transduction Negative Regulation Of Translation Apoptotic Process Programmed Cell Death Regulation Of Protein Metabolic Process Cell Death Death Response To Stimulus Cellular Metabolic Process Response To Organic Substance Cellular Response To Organic Substance Regulation Of Mitotic Cell Cycle Response To Stress Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Long-term Memory Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Interleukin-4 Cellular Response To Stress Negative Regulation Of Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Response To Interleukin-4 Protein Ubiquitination Cellular Response To Growth Factor Stimulus Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cell Migration Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Morphogenesis Of A Branching Structure Response To Growth Factor Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Translation In Response To Oxidative Stress
Tagcloud ?			aggravating airway airways asthma asthmatic ats cawr coexisting expiratory fev1 forced fvc gastroesophageal gerd hz impulse ios ninety oscillometry pef plethysmography presences reflux representative sec severity tawr verified vital
Tagcloud (Difference) ?			aggravating airway airways asthma asthmatic ats cawr coexisting expiratory fev1 forced fvc gastroesophageal gerd hz impulse ios ninety oscillometry pef plethysmography presences reflux representative sec severity tawr verified vital
Tagcloud (Intersection) ?