SPSB4

Description		splA/ryanodine receptor domain and SOCS box containing 4
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GO Annotations	Cellular Component	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Rhythmic Process Positive Regulation Of Protein Polyubiquitination
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Ischemic stroke ( 24262325) Response to citalopram or escitalopram in depression ( 27622933) Schizophrenia x sex interaction ( 34099189) Stroke (ischemic) ( 23041239)
Interacting Genes		2 interacting genes: DDX4 NOS2
Entrez ID		92369
HPRD ID		18108
Ensembl ID		ENSG00000175093
Uniprot IDs		Q96A44
PDB IDs		2V24 6DN7 6DN8
Enriched GO Terms of Interacting Partners?		Nitric-oxide Synthase Activity Peptidyl-cysteine S-nitrosylation Tetrahydrobiopterin Binding Prostaglandin Secretion Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation PiP-body Arginine Metabolic Process L-arginine Catabolic Process Perinuclear Region Of Cytoplasm Innate Immune Response In Mucosa Lipid Export From Cell Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Nitric Oxide Mediated Signal Transduction FMN Binding Arginine Binding Prostaglandin Transport Nitric Oxide Biosynthetic Process Pi-body Transposable Element Silencing By PiRNA-mediated DNA Methylation Regulatory NcRNA-mediated Heterochromatin Formation PiRNA Processing P Granule Transposable Element Silencing By Heterochromatin Formation Fc Receptor Mediated Stimulatory Signaling Pathway Male Meiosis I Cortical Cytoskeleton Mucosal Immune Response Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Organ Or Tissue Specific Immune Response Fc-gamma Receptor Signaling Pathway NADP Binding Negative Regulation Of Gene Expression Transposable Element Silencing Meiosis I DNA Methylation-dependent Constitutive Heterochromatin Formation Cell Redox Homeostasis Regulation Of Cellular Respiration Superoxide Metabolic Process Negative Regulation Of Blood Pressure Peroxisomal Matrix Male Meiotic Nuclear Division Molecular Condensate Scaffold Activity Fc Receptor Signaling Pathway Constitutive Heterochromatin Formation Glutamine Family Amino Acid Metabolic Process Flavin Adenine Dinucleotide Binding Positive Regulation Of Interleukin-8 Production Cellular Response To Xenobiotic Stimulus Positive Regulation Of Leukocyte Mediated Cytotoxicity
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