PAWR and FBXO45

Number of citations of the paper that reports this interaction (PMID 24992930)
0

Data Source:
BioGRID (enzymatic study)

		PAWR	FBXO45
Gene Name		PRKC, apoptosis, WT1, regulator	F-box protein 45
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Actin Filament Plasma Membrane Actin Cytoskeleton	Postsynaptic Density Cell Junction Presynaptic Membrane Postsynaptic Membrane
	Molecular Function	Transcription Corepressor Activity Actin Binding Protein Binding Enzyme Binding Leucine Zipper Domain Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Negative Regulation Of Cell Proliferation Negative Regulation Of B Cell Proliferation Interleukin-2 Biosynthetic Process Negative Regulation Of T Cell Proliferation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Apoptotic Signaling Pathway	Neuron Migration Cellular Response To DNA Damage Stimulus Protein Ubiquitination Cerebral Cortex Radially Oriented Cell Migration Cerebral Cortex Tangential Migration Corticospinal Tract Morphogenesis Anterior Commissure Morphogenesis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Synapse Assembly Involved In Innervation
Pathways
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430)
Protein-Protein Interactions		17 interactors: AATF ATP5C1 DAPK3 DRD2 FBXO45 HSPA5 PML PRKCZ RRAS2 SLC5A7 SPSB1 SPSB2 SPSB4 SQSTM1 TFPT THAP1 WT1	2 interactors: PAWR TP73
Entrez ID		5074	200933
HPRD ID		09051	19508
Ensembl ID			ENSG00000174013
Uniprot IDs		Q96IZ0	P0C2W1
PDB IDs		2JK9
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Death Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Apoptotic Signaling Pathway Cellular Response To Stimulus Signaling Cell Communication Signal Transduction Negative Regulation Of Translation Apoptotic Process Programmed Cell Death Regulation Of Protein Metabolic Process Cell Death Death Response To Stimulus Cellular Metabolic Process Response To Organic Substance Cellular Response To Organic Substance Regulation Of Mitotic Cell Cycle Response To Stress Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Long-term Memory Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Interleukin-4 Cellular Response To Stress Negative Regulation Of Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Response To Interleukin-4 Protein Ubiquitination Cellular Response To Growth Factor Stimulus Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cell Migration Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Morphogenesis Of A Branching Structure Response To Growth Factor Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Translation In Response To Oxidative Stress	Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Interleukin-2 Biosynthetic Process Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cerebrospinal Fluid Secretion Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Interleukin-2 Production Positive Regulation Of Cell Death Negative Regulation Of Cell Proliferation Negative Regulation Of JUN Kinase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Glycoprotein Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Cell Size Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of B Cell Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Apoptotic Process Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Cardiac Muscle Tissue Development Programmed Cell Death Cytokine Biosynthetic Process Cell Death Death Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Regulation Of Glycoprotein Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cytokine Metabolic Process Negative Regulation Of Signaling Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To X-ray Negative Regulation Of JNK Cascade Release Of Cytochrome C From Mitochondria Positive Regulation Of Protein Metabolic Process Negative Regulation Of Stress-activated MAPK Cascade Negative Regulation Of B Cell Activation Negative Regulation Of Gene Expression Negative Regulation Of Organ Growth Positive Regulation Of Glial Cell Differentiation Negative Regulation Of Biosynthetic Process
Tagcloud ?		aggravating airway airways asthma asthmatic ats cawr coexisting expiratory fev1 forced fvc gastroesophageal gerd hz impulse ios ninety oscillometry pef plethysmography presences reflux representative sec severity tawr verified vital	asd asds autism connectivity contributors deleterious hamartin idiopathic intronic mounting mtorc1 mycbp2 neurodevelopment pam pools proband representation resequenced rheb sanger simons splice synapse trios tsc tsc1 tsc2 tuberin variants
Tagcloud (Difference) ?		aggravating airway airways asthma asthmatic ats cawr coexisting expiratory fev1 forced fvc gastroesophageal gerd hz impulse ios ninety oscillometry pef plethysmography presences reflux representative sec severity tawr verified vital	asd asds autism connectivity contributors deleterious hamartin idiopathic intronic mounting mtorc1 mycbp2 neurodevelopment pam pools proband representation resequenced rheb sanger simons splice synapse trios tsc tsc1 tsc2 tuberin variants
Tagcloud (Intersection) ?