SATB2 and POLR2J3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SATB2	POLR2J3
Description		SATB homeobox 2	RNA polymerase II subunit J3
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nuclear Matrix Nuclear Lumen	DNA-directed RNA Polymerase Complex Nucleus RNA Polymerase II, Core Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Osteoblast Development Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Embryonic Pattern Specification Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Cartilage Development Roof Of Mouth Development	DNA-templated Transcription Transcription By RNA Polymerase II
Pathways		SUMOylation of chromatin organization proteins RUNX2 regulates osteoblast differentiation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Brain cytoarchitecture ( 20308991) Cerebrospinal fluid immune biomarker levels ( 32066700) Chin dimples ( 27182965) Colorectal cancer or advanced adenoma ( 30510241) Cortical volume ( 32963231) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Height ( 31562340) Insomnia ( 23728906) Loneliness (multivariate analysis) ( 27629369) Lung function (FVC) ( 30804560) Menarche (age at onset) ( 25231870 27182965 29773799) Rheumatoid arthritis ( 30891314) Schizophrenia ( 29483656 30285260 28991256 25056061) Serum alkaline phosphatase levels ( 33547301) Sun-seeking behavior ( 32920024) Type 2 diabetes ( 25760438) Ulcerative colitis ( 20228799) Waist circumference ( 23966867)
Interacting Genes		8 interacting genes: FOXP1 FOXP2 FOXP4 HDAC1 MTA2 PIAS1 POLR2J3 RAB3IL1	6 interacting genes: ATPAF2 POLR1C SATB2 TRAF4 TTC23 VPS37C
Entrez ID		23314	548644
HPRD ID		12178	18684
Ensembl ID		ENSG00000119042	ENSG00000285437
Uniprot IDs		B3KPQ9 Q59FT3 Q9UPW6	A0A0B4J2F8 Q9H1A7
PDB IDs		1WI3 1WIZ 2CSF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Androgen Receptor Signaling Pathway NuRD Complex DNA Binding Core Promoter Sequence-specific DNA Binding Negative Regulation Of RNA Biosynthetic Process Histone Deacetylase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Fate Specification Regulation Of Muscle Cell Differentiation Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Regulation Of Androgen Receptor Signaling Pathway Transcription Corepressor Activity Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nucleosomal DNA Binding Histone Deacetylase Complex Regulation Of Cell Fate Commitment DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Biosynthetic Process Putamen Development Caudate Nucleus Development Negative Regulation Of Biosynthetic Process Negative Regulation Of Muscle Cell Differentiation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Stem Cell Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Krueppel-associated Box Domain Binding Regulation Of Transcription By RNA Polymerase II Zonula Adherens Assembly Positive Regulation Of Interleukin-21 Production Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Macromolecule Metabolic Process Protein Lysine Delactylase Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Fungiform Papilla Formation Negative Regulation Of Metabolic Process Protein Decrotonylase Activity Histone Decrotonylase Activity Transcription Coregulator Activity Histone Deacetylase Binding Hair Follicle Placode Formation Zinc Ion Binding Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Smooth Muscle Cell Proliferation
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