NACC2

Description		NACC family member 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleolus Mitochondrion Nuclear Lumen
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Protein-containing Complex Localization Regulation Of Cell Population Proliferation Negative Regulation Of DNA-templated Transcription Protein Homooligomerization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Sjögren's syndrome ( 28076899) Ulcerative colitis ( 28067908)
Interacting Genes		5 interacting genes: EPS8 HDAC2 MTA1 MTA2 MTA3
Entrez ID		138151
HPRD ID		09831
Ensembl ID		ENSG00000148411
Uniprot IDs		Q96BF6
PDB IDs
Enriched GO Terms of Interacting Partners?		NuRD Complex Regulation Of Cell Fate Specification Regulation Of Cell Fate Commitment Regulation Of Stem Cell Differentiation Histone Deacetylase Binding Behavioral Response To Ethanol Chromatin Binding Chromatin Remodeling Histone Deacetylase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Corepressor Activity Chromatin Organization Epigenetic Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Nucleosomal DNA Binding Transcription Coactivator Activity Regulation Of Developmental Process Histone Deacetylase Complex Circadian Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Male Mating Behavior Positive Regulation Of Granulosa Cell Proliferation Granulosa Cell Proliferation Regulation Of Cell Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Protein De-2-hydroxyisobutyrylase Activity Circadian Rhythm Mitotic Cell Cycle Phase Transition Adult Behavior Cell Cycle Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Lysine Delactylase Activity Fungiform Papilla Formation Positive Regulation Of Protein Autoubiquitination Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region DNA-binding Transcription Factor Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Locomotory Behavior Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Hair Follicle Placode Formation Regulation Of Protein Autoubiquitination
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