NACC2 and MTA3

Number of citations of the paper that reports this interaction (PubMedID 22926524)
0

Data Source:
BioGRID (pull down)

		NACC2	MTA3
Description		NACC family member 2	metastasis associated 1 family member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleolus Mitochondrion Nuclear Lumen	Nucleus Nucleoplasm Cytoplasm NuRD Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Protein-containing Complex Binding	DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Protein-containing Complex Localization Regulation Of Cell Population Proliferation Negative Regulation Of DNA-templated Transcription Protein Homooligomerization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Cell Population Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Granulosa Cell Proliferation Granulosa Cell Proliferation Regulation Of Stem Cell Differentiation
Pathways			HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Sjögren's syndrome ( 28076899) Ulcerative colitis ( 28067908)	Breastfeeding duration ( 25475840)
Interacting Genes		5 interacting genes: EPS8 HDAC2 MTA1 MTA2 MTA3	23 interacting genes: AKT1 ARNT ATM AURKA BAG4 BCAR3 BCL6 CDKN2C DSCAM DYRK1A ERCC6 FGFR2 FGFR4 FOXK2 FZR1 GRB2 IGF1R KDM1A NACC2 NOTCH2 PARP1 TGFB1 TSG101
Entrez ID		138151	57504
HPRD ID		09831	12359
Ensembl ID		ENSG00000148411	ENSG00000057935
Uniprot IDs		Q96BF6	F6RRE2 Q9BTC8
PDB IDs
Enriched GO Terms of Interacting Partners?		NuRD Complex Regulation Of Cell Fate Specification Regulation Of Cell Fate Commitment Regulation Of Stem Cell Differentiation Histone Deacetylase Binding Behavioral Response To Ethanol Chromatin Binding Chromatin Remodeling Histone Deacetylase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Corepressor Activity Chromatin Organization Epigenetic Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Nucleosomal DNA Binding Transcription Coactivator Activity Regulation Of Developmental Process Histone Deacetylase Complex Circadian Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Male Mating Behavior Positive Regulation Of Granulosa Cell Proliferation Granulosa Cell Proliferation Regulation Of Cell Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Protein De-2-hydroxyisobutyrylase Activity Circadian Rhythm Mitotic Cell Cycle Phase Transition Adult Behavior Cell Cycle Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Lysine Delactylase Activity Fungiform Papilla Formation Positive Regulation Of Protein Autoubiquitination Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region DNA-binding Transcription Factor Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Locomotory Behavior Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Hair Follicle Placode Formation Regulation Of Protein Autoubiquitination	Regulation Of Intracellular Signal Transduction Protein Autophosphorylation Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Component Organization Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Regulation Of DNA Recombination Response To Ionizing Radiation Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Regulation Of DNA Metabolic Process Negative Regulation Of Metabolic Process Cell Differentiation Positive Regulation Of Signal Transduction Protein Phosphorylation Cellular Developmental Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Phosphorylation Regulation Of Signal Transduction By P53 Class Mediator Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Apoptotic Process Response To Gamma Radiation Positive Regulation Of Cellular Component Organization Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Differentiation Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Organelle Organization Response To Radiation Positive Regulation Of Fibroblast Migration Regulation Of Cell Cycle Phase Transition Positive Regulation Of DNA Metabolic Process Cellular Response To Stress Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process
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