NPC1 and BUD31

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		NPC1	BUD31
Description		NPC intracellular cholesterol transporter 1	BUD31 spliceosome associated protein
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GO Annotations	Cellular Component	Extracellular Region Nuclear Envelope Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Late Endosome Membrane Vesicle Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome	Chromatin Nucleus Nucleoplasm Spliceosomal Complex Centrosome Microtubule Cytoskeleton U2-type Catalytic Step 2 Spliceosome
	Molecular Function	Virus Receptor Activity Transmembrane Signaling Receptor Activity Lipid Transporter Activity Protein Binding Cholesterol Binding Signaling Receptor Activity Cholesterol Transfer Activity	Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding
	Biological Process	Liver Development Protein Glycosylation Lipid Metabolic Process Lipid Transport Endocytosis Autophagy Lysosomal Transport Adult Walking Behavior Steroid Metabolic Process Cholesterol Metabolic Process Bile Acid Metabolic Process Response To Xenobiotic Stimulus Gene Expression Cholesterol Storage Programmed Cell Death Sterol Transport Sterol Metabolic Process Macroautophagy Negative Regulation Of Macroautophagy Neurogenesis Intestinal Cholesterol Absorption Cholesterol Transport Membrane Raft Organization Intracellular Lipid Transport Intracellular Cholesterol Transport Cholesterol Efflux Cholesterol Homeostasis Response To Cadmium Ion Symbiont Entry Into Host Cell Establishment Of Localization In Cell Cellular Response To Steroid Hormone Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Establishment Of Protein Localization To Membrane Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of TORC1 Signaling Cyclodextrin Metabolic Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Positive Regulation Of DNA-templated Transcription
Pathways		LDL clearance	mRNA Splicing - Major Pathway
Drugs
Diseases		Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Body mass index ( 29273807) Body size at age 10 ( 32376654) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Granulocyte count ( 27863252) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Household income (MTAG) ( 31844048) Mental health study participation (provided email address) ( 31263887) Metabolic syndrome ( 31589552) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Obesity ( 19151714) Poultry consumption ( 32066663) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Triglyceride levels ( 32154731 32203549) Triglycerides ( 30275531) Walking pace ( 33128006) White blood cell count ( 27863252)	Facial emotion recognition (sad faces) ( 28608620) Serum metabolite levels ( 23093944)
Interacting Genes		6 interacting genes: BUD31 DYRK1A GPR35 MC4R MTDH VPS4A	25 interacting genes: ADCY7 APP ATP13A1 BEND5 CCT3 CEBPA CTNNBL1 ERGIC3 HLA-A HOXA1 HTR5A KRTAP10-3 KRTAP10-7 MARCHF6 MEOX2 MMP24 NPC1 PANX1 PICK1 RELB RNF208 SCAF1 SF1 TMEM94 TSPAN7
Entrez ID		4864	8896
HPRD ID		09622	10351
Ensembl ID		ENSG00000141458	ENSG00000106245
Uniprot IDs		O15118	P41223
PDB IDs		3GKH 3GKI 3GKJ 3JD8 5F18 5F1B 5HNS 5JNX 5KWY 5U73 5U74 6UOX 6W5R 6W5S 6W5T 6W5U 6W5V 8EUS 9DZ2	4OED 4OH6 4OKB 5MQF 5XJC 5YZG 5Z56 5Z57 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7AAV 7ABF 7ABG 7ABI 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8Q7N 8QO9 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Viral Life Cycle Transcription Coactivator Activity Histone H3T45 Kinase Activity Response To Melanocyte-stimulating Hormone Negative Regulation Of Nerve Growth Factor Production Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Positive Regulation Of Viral Process Zymogen Inhibition Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Actomyosin Contractile Ring Contraction Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Late Endosomal Microautophagy Contractile Ring Contraction Regulation Of Viral Life Cycle Melanocyte-stimulating Hormone Receptor Activity Negative Regulation Of Receptor Catabolic Process Positive Regulation Of Viral Budding Via Host ESCRT Complex Regulation Of Viral Process Viral Translation Viral Life Cycle Viral Process Mitotic Cytokinesis Checkpoint Signaling Centrosome Negative Regulation Of Heterochromatin Formation Melanocortin Receptor Activity Cytokine Precursor Processing Biological Process Involved In Interaction With Host Nerve Growth Factor Binding Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production ATP-dependent Protein Disaggregase Activity Vesicle Uncoating Intercellular Canaliculus Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Cytokinesis C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Eating Behavior Heparan Sulfate Binding Regulation Of Heterochromatin Formation Signal Peptide Processing RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Mitotic Nuclear Membrane Reassembly
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