NPC1

Gene Name		Niemann-Pick disease, type C1
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Gene Ontology Annotations	Cellular Component	Extracellular Region Nuclear Envelope Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Late Endosome Membrane Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Hedgehog Receptor Activity Sterol Transporter Activity Cholesterol Binding
	Biological Process	Protein Glycosylation Endocytosis Autophagy Lysosomal Transport Signal Transduction Adult Walking Behavior Cholesterol Metabolic Process Bile Acid Metabolic Process Negative Regulation Of Macroautophagy Cholesterol Transport Membrane Raft Organization Cholesterol Efflux Response To Drug Cholesterol Homeostasis Response To Cadmium Ion Negative Regulation Of Cell Death Cellular Response To Steroid Hormone Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Establishment Of Protein Localization To Membrane
Pathways
Drugs
Diseases
GWAS		Obesity ( 19151714)
Protein-protein Interactions		1 interactors: VPS4A
Entrez ID		4864
HPRD ID		09622
Ensembl ID		ENSG00000141458
Uniprot IDs		O15118
PDB IDs		3GKH 3GKI 3GKJ
Enriched GO Terms of Interacting Partners?		Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Abscission Viral Budding Via Host ESCRT Complex Viral Budding Negative Regulation Of Cytokinesis Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Cell Separation After Cytokinesis Virion Assembly Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Metaphase Plate Congression Metaphase Plate Congression Establishment Of Chromosome Localization Regulation Of Cytokinesis Positive Regulation Of Exocytosis Mitotic Sister Chromatid Segregation Membrane Budding Negative Regulation Of Cell Division Sister Chromatid Segregation Vacuole Organization Cytokinesis Nucleus Organization Regulation Of Exocytosis Viral Life Cycle Endosomal Transport Vesicle Organization Chromosome Segregation Regulation Of Cell Division Mitotic Nuclear Division Positive Regulation Of Secretion Establishment Of Organelle Localization Regulation Of Vesicle-mediated Transport Organelle Localization Cell Division Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Secretion
Tagcloud ?		9years assume autosomal carriers connection deterioration distinctive expand gaucher gba gd glucocerebrosidase heterozygous lysosomal mentioned miglustat mind neurodegenerative niemann npc2 pick psen1 psen2 recessive sometimes storage trying worth