ZMYM5 and CBS

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid, two hybrid)

		ZMYM5	CBS
Description		zinc finger MYM-type containing 5	cystathionine beta-synthase
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GO Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Catalytic Activity Cystathionine Beta-synthase Activity Protein Binding Lyase Activity Oxygen Binding Enzyme Binding Heme Binding Pyridoxal Phosphate Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Nitrite Reductase (NO-forming) Activity Carbon Monoxide Binding Nitric Oxide Binding Modified Amino Acid Binding S-adenosyl-L-methionine Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II	Endochondral Ossification Blood Vessel Remodeling Cysteine Metabolic Process Cysteine Biosynthetic Process From Serine L-serine Metabolic Process L-serine Catabolic Process Superoxide Metabolic Process Amino Acid Biosynthetic Process Serine Family Amino Acid Metabolic Process Regulation Of Nitric Oxide Mediated Signal Transduction Cysteine Biosynthetic Process Via Cystathionine Cysteine Biosynthetic Process Transsulfuration L-cysteine Catabolic Process Cerebellum Morphogenesis Response To Nutrient Levels DNA Protection Negative Regulation Of Apoptotic Process Homocysteine Catabolic Process Sulfur Compound Biosynthetic Process Regulation Of JNK Cascade Homocysteine Metabolic Process Response To Folic Acid Maternal Process Involved In Female Pregnancy Cartilage Development Involved In Endochondral Bone Morphogenesis Hydrogen Sulfide Biosynthetic Process Cellular Response To Hypoxia Blood Vessel Diameter Maintenance
Pathways			Cysteine formation from homocysteine Metabolism of ingested SeMet, Sec, MeSec into H2Se
Drugs			Pyridoxal phosphate Ademetionine Serine Cysteine
Diseases			Homocystinuria
GWAS		Alcohol use disorder (consumption score) ( 30940813) Arterial stiffness (brachial-ankle pulse wave velocity) ( 32790701) Methadone dose in opioid dependence ( 28115739)	Blood and toenail selenium levels ( 25343990) Blood trace element (Se levels) ( 23720494) Homocysteine levels ( 20031578 23824729) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Plasma homocysteine levels (post-methionine load test) ( 24651765) Pre-treatment viral load in HIV-1 infection ( 31219150) Serum metabolite levels ( 33031748)
Interacting Genes		33 interacting genes: - APP CAMK2B CARD9 CBS CREBBP DAPK1 DES FADD FBXO7 FTCD GTF2IRD1 HMBOX1 HOMER1 ITSN1 LCE3B LRRK2 MFHAS1 MORC3 PAX5 PDE9A PRMT1 SKIL SNIP1 SUMO1 SUMO2 TFG TRAF2 TRAF4 TRIP13 UBQLN1 ZBTB26 ZNRD2	35 interacting genes: ATRX CBX4 CERT1 DAXX EHHADH FAF1 FXR1 FXR2 HGS HID1 HIPK1 HTT NTAQ1 PAX6 PIAS1 PIAS2 PIAS3 PIN1 PRKAG1 PRKAR1A PSMA1 RANBP9 SATB1 SLF2 SMARCAD1 SNCA SNRNP70 UBASH3A UBE2I UGP2 VTA1 ZDHHC17 ZMYM5 ZNF181 ZNF451
Entrez ID		9205	875
HPRD ID		10324	01994
Ensembl ID		ENSG00000132950	ENSG00000160200
Uniprot IDs		Q9UJ78	B7Z2D6 P35520
PDB IDs		2DAS	1JBQ 1M54 4COO 4L0D 4L27 4L28 4L3V 4PCU 4UUU 5MMS 7QGT 8S5H 8S5I 8S5J 8S5K 8S5L 8S5M 8STW
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Regulation Of JNK Cascade Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signaling Adaptor Activity Positive Regulation Of Protein Metabolic Process PML Body Positive Regulation Of Proteolysis Regulation Of MAPK Cascade Response To Stress Cysteine Biosynthetic Process From Serine Cystathionine Beta-synthase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Protein-containing Complex Organization Regulation Of Apoptotic Process Regulation Of Postsynapse Organization Cytosol Regulation Of Apoptotic Signaling Pathway S-adenosyl-L-methionine Binding Enzyme Binding Regulation Of Programmed Cell Death Cysteine Biosynthetic Process Via Cystathionine Carbon Monoxide Binding Protein-containing Complex Assembly Positive Regulation Of MAPK Cascade Cysteine Biosynthetic Process Homocysteine Catabolic Process Hydrogen Sulfide Biosynthetic Process Cellular Response To Stress Presynaptic Cytosol Positive Regulation Of Signal Transduction Postsynaptic Cytosol Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Multicellular Organismal Process L-serine Catabolic Process Transsulfuration Nitrite Reductase (NO-forming) Activity Cerebellum Morphogenesis Hydrogen Sulfide Metabolic Process L-cysteine Catabolic Process Nitric Oxide Binding Tumor Necrosis Factor Receptor Binding Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade	PML Body Protein Sumoylation SUMO Ligase Activity SUMO Transferase Activity Postsynaptic Cytosol Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Presynaptic Cytosol Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nuclear Speck Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of RNA Metabolic Process Enzyme Binding Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Stress Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Protein Modification Process Transcription Corepressor Activity Phosphoprotein Binding Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Macromolecule Metabolic Process CAMP-dependent Protein Kinase Regulator Activity Nuclear Body Protein Domain Specific Binding Regulation Of Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Iris Morphogenesis Regulation Of Chaperone-mediated Autophagy Glutamatergic Synapse Cytosol Regulation Of Protein Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process
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