ZMYM5 and FTCD

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		ZMYM5	FTCD
Description		zinc finger MYM-type containing 5	formimidoyltransferase cyclodeaminase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Centriole Cytosol Cytoskeleton Plasma Membrane Smooth Endoplasmic Reticulum Membrane Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Catalytic Activity Protein Binding Folic Acid Binding Microtubule Binding Transferase Activity Lyase Activity Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II	L-histidine Metabolic Process Folic Acid-containing Compound Metabolic Process Cytoskeleton Organization L-histidine Catabolic Process To Glutamate And Formamide L-histidine Catabolic Process To Glutamate And Formate
Pathways			Histidine catabolism
Drugs			Tetrahydrofolic acid Glutamic acid (6R)-Folinic acid
Diseases
GWAS		Alcohol use disorder (consumption score) ( 30940813) Arterial stiffness (brachial-ankle pulse wave velocity) ( 32790701) Methadone dose in opioid dependence ( 28115739)	Blood protein levels ( 30072576) Mastocytosis ( 32752121) Refractive error ( 32231278)
Interacting Genes		33 interacting genes: - APP CAMK2B CARD9 CBS CREBBP DAPK1 DES FADD FBXO7 FTCD GTF2IRD1 HMBOX1 HOMER1 ITSN1 LCE3B LRRK2 MFHAS1 MORC3 PAX5 PDE9A PRMT1 SKIL SNIP1 SUMO1 SUMO2 TFG TRAF2 TRAF4 TRIP13 UBQLN1 ZBTB26 ZNRD2	23 interacting genes: BEX3 BIRC2 CCDC183 DGCR6 DNM1 DST EIF4A1 EIF4A2 GAD2 HGS HSPA1A HSPA1B HSPA2 IDS KASH5 MED4 NAA25 PALS1 RDX SNRNP70 SPTBN1 USP34 ZMYM5
Entrez ID		9205	10841
HPRD ID		10324	08430
Ensembl ID		ENSG00000132950	ENSG00000160282
Uniprot IDs		Q9UJ78	O95954
PDB IDs		2DAS
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Regulation Of JNK Cascade Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signaling Adaptor Activity Positive Regulation Of Protein Metabolic Process PML Body Positive Regulation Of Proteolysis Regulation Of MAPK Cascade Response To Stress Cysteine Biosynthetic Process From Serine Cystathionine Beta-synthase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Protein-containing Complex Organization Regulation Of Apoptotic Process Regulation Of Postsynapse Organization Cytosol Regulation Of Apoptotic Signaling Pathway S-adenosyl-L-methionine Binding Enzyme Binding Regulation Of Programmed Cell Death Cysteine Biosynthetic Process Via Cystathionine Carbon Monoxide Binding Protein-containing Complex Assembly Positive Regulation Of MAPK Cascade Cysteine Biosynthetic Process Homocysteine Catabolic Process Hydrogen Sulfide Biosynthetic Process Cellular Response To Stress Presynaptic Cytosol Positive Regulation Of Signal Transduction Postsynaptic Cytosol Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Multicellular Organismal Process L-serine Catabolic Process Transsulfuration Nitrite Reductase (NO-forming) Activity Cerebellum Morphogenesis Hydrogen Sulfide Metabolic Process L-cysteine Catabolic Process Nitric Oxide Binding Tumor Necrosis Factor Receptor Binding Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade	Negative Regulation Of Inclusion Body Assembly Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Heat Shock Protein Binding Regulation Of Inclusion Body Assembly Response To Heat Protein Refolding ATP-dependent Protein Folding Chaperone C3HC4-type RING Finger Domain Binding ATP-dependent Protein Disaggregase Activity Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Negative Regulation Of Cellular Component Organization Cellular Response To Heat Positive Regulation Of Microtubule Nucleation Response To Temperature Stimulus Protein Folding Chaperone Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process RNA Binding ATP Hydrolysis Activity Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Protein-containing Complex Assembly Negative Regulation Of Post-translational Protein Modification Inclusion Body Regulation Of Microtubule Nucleation Regulation Of Post-translational Protein Modification Regulation Of Mitotic Spindle Assembly Protein-containing Complex Unfolded Protein Binding Blood Microparticle Histone Deacetylase Binding Protein Localization To Membrane Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Extracellular Exosome Clathrin Coat Assembly Involved In Endocytosis Cytoplasmic Translational Initiation Negative Regulation Of RNA-dependent RNA Polymerase Activity Positive Regulation Of Male Mating Behavior Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Erythrocyte Differentiation Aggresome Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
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