ARHGEF12 and LPAR1

Number of citations of the paper that reports this interaction (PubMedID 15755723)
0

Data Source:
HPRD (in vitro, in vivo)

		ARHGEF12	LPAR1
Description		Rho guanine nucleotide exchange factor 12	lysophosphatidic acid receptor 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Extracellular Exosome	Cytoplasm Endosome Plasma Membrane Cell Surface Membrane Endocytic Vesicle Presynaptic Membrane Neuronal Cell Body Dendritic Spine Dendritic Shaft Postsynaptic Membrane Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	G Protein-coupled Receptor Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Protein Binding Phospholipid Binding Lipid Binding PDZ Domain Binding Lysophosphatidic Acid Binding Lysophosphatidic Acid Receptor Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Rho-activating G Protein-coupled Receptor Signaling Pathway	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cell Shape Negative Regulation Of Neuron Projection Development Oligodendrocyte Development Cerebellum Development Optic Nerve Development Neurogenesis Corpus Callosum Development Bleb Assembly Positive Regulation Of Rho Protein Signal Transduction Myelination Golgi To Plasma Membrane Protein Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Cilium Assembly Positive Regulation Of Stress Fiber Assembly Cell Chemotaxis Regulation Of Vesicle-mediated Transport Positive Regulation Of Dendritic Spine Development Protein Localization To Cilium Cellular Response To Oxygen Levels Positive Regulation Of Smooth Muscle Cell Chemotaxis Regulation Of Synaptic Vesicle Cycle Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Cilium Assembly Cellular Response To 1-oleoyl-sn-glycerol 3-phosphate
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle	G alpha (q) signalling events G alpha (i) signalling events Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder symptom score ( 27663945) Coronary artery disease ( 29212778) Glaucoma ( 31959993 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935 25173105) Height ( 31562340) Intraocular pressure ( 30054594 31798171 29785010 29617998 31959993 29235454 28073927 25637523) Monocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)	Birth weight ( 27680694 31043758) Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159 31798171 30894546 29760442) Corneal structure ( 23291589) Cortical thickness ( 32963231) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Height ( 31562340 25282103 20881960) Monocyte count ( 28031487 28193307 29403010 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Offspring birth weight ( 31043758) Post bronchodilator FEV1 in COPD ( 26634245) Pursuit maintenance gain ( 29064472) Sum eosinophil basophil counts ( 27863252) White blood cell count (monocyte) ( 28158719) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		18 interacting genes: ABCA1 CD44 CLK1 CUL3 EGFR GNA12 GNA13 IGF1R KLHL20 LPAR1 LPAR2 PLXNB1 PLXNB2 PTPRF RHOA RPS6KA1 TEC VANGL2	7 interacting genes: ARHGEF11 ARHGEF12 DRD2 GIPC1 GNAI3 KRAS NHERF2
Entrez ID		23365	1902
HPRD ID		09207	03790
Ensembl ID		ENSG00000196914	ENSG00000198121
Uniprot IDs		B4E2K6 E9PMR6 Q9NZN5	Q5VZX0 Q6GPG7 Q92633
PDB IDs		1TXD 1X86 2OMJ 2OS6	4Z34 4Z35 4Z36 7TD0 7TD1 7TD2 7YU3 7YU4 7YU5 7YU6 7YU7 7YU8 9IZF 9IZG 9IZH 9J5V
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction Regulation Of Cell Morphogenesis Regulation Of Cell Shape Regulation Of Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Endocytic Vesicle Regulation Of Developmental Process D5 Dopamine Receptor Binding Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Plasma Membrane Cell Migration Positive Regulation Of Rho Protein Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Motility Lysophosphatidic Acid Receptor Activity Cell Motility Regulation Of Locomotion Protein Tyrosine Kinase Activity Apolipoprotein A-I-mediated Signaling Pathway Semaphorin-plexin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Rho-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Glutamatergic Synapse Regulation Of Anatomical Structure Morphogenesis Nucleotide Binding Ossification Involved In Bone Maturation Cell Surface Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization G Protein Activity Positive Regulation Of Small GTPase Mediated Signal Transduction Focal Adhesion Anatomical Structure Morphogenesis Regulation Of Neuron Projection Development Semaphorin Receptor Activity Transmembrane Signaling Receptor Activity Semaphorin Receptor Complex Positive Regulation Of MAPK Cascade Positive Regulation Of Cellular Component Organization Basolateral Plasma Membrane Negative Regulation Of Intracellular Signal Transduction	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding Regulation Of Synaptic Transmission, GABAergic Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Protein-membrane Adaptor Activity Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cytokinesis Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette Visual Learning Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Neuronal Synaptic Plasticity Visual Behavior Rho Protein Signal Transduction Signaling Receptor Binding GDP Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cytokinesis Positive Regulation Of Cell Division Associative Learning Modulation Of Chemical Synaptic Transmission G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Type 2 Metabotropic Glutamate Receptor Binding Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Receptor Signaling Pathway GMP Binding Forebrain Astrocyte Development Type 3 Metabotropic Glutamate Receptor Binding Signal Transduction Membrane Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Golgi Membrane Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Dopamine Secretion Dendritic Spine Response To Isolation Stress Learning Morphogenesis Of A Branching Structure Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Dephosphorylation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression
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