ARHGEF12 and CUL3

Number of citations of the paper that reports this interaction (PMID 21670212)
5

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ARHGEF12	CUL3
Gene Name		Rho guanine nucleotide exchange factor (GEF) 12	cullin 3
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Membrane Extracellular Vesicular Exosome	Golgi Membrane Nucleoplasm Polar Microtubule Cytosol Membrane Cul3-RING Ubiquitin Ligase Complex Extracellular Vesicular Exosome
	Molecular Function	G-protein Coupled Receptor Binding Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Cyclin Binding POZ Domain Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Trophectodermal Cellular Morphogenesis Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Cell Cycle Arrest Mitotic Metaphase Plate Congression Integrin-mediated Signaling Pathway Gastrulation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Positive Regulation Of Cell Proliferation Wnt Signaling Pathway Cell Migration Protein Ubiquitination Stem Cell Division Positive Regulation Of Cytokinesis Negative Regulation Of Rho Protein Signal Transduction Embryonic Cleavage Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway Intrinsic Apoptotic Signaling Pathway
Pathways		Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE Semaphorin interactions p75 NTR receptor-mediated signalling Rho GTPase cycle GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse	Antigen processing: Ubiquitination & Proteasome degradation misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Hedgehog 'on' state XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Hedgehog degradation of DVL Class I MHC mediated antigen processing & presentation Signaling by WNT in cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ABCA1 CD44 CUL3 GNA12 GNA13 IGF1R KLHL20 LPAR1 LPAR2 PLXNB1 PLXNB2 RHOA TEC	54 interactors: ABTB1 ABTB2 APP ARHGEF12 BTBD10 CAMK1D CAND1 CCND1 CCNE1 CDC25A CDC34 COMMD1 DCUN1D1 DCUN1D4 DYRK4 EFNB1 FOLR1 GMCL1 GPS1 HLA-DMB HSF2 KCTD13 KCTD5 KCTD6 KCTD9 KLHL12 KLHL2 KLHL20 KLHL3 KLHL42 KLHL5 NEDD8 OLIG2 PDIA2 RBX1 RCBTB1 RCBTB2 RHOBTB3 RIT1 RNF7 SHKBP1 SUMO2 SUMO3 TCEB1 TNFAIP1 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2M WNT7B ZMAT4
Entrez ID		23365	8452
HPRD ID		09207	09123
Ensembl ID		ENSG00000196914	ENSG00000036257
Uniprot IDs		B4E2K6 E9PMR6 Q9NZN5	B7Z600 Q13618
PDB IDs		1TXD 1X86 2OMJ 2OS6	4AP2 4APF 4EOZ 4HXI
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Signal Transduction Signal Transduction Regulation Of Signaling Regulation Of Cell Migration Signaling Cell Communication Regulation Of Cell Motility Anatomical Structure Morphogenesis Tissue Morphogenesis Regulation Of Ras Protein Signal Transduction Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Stimulus Positive Regulation Of Cytokinesis Regulation Of Cell Shape Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of Cell Morphogenesis Apolipoprotein A-I-mediated Signaling Pathway Regulation Of Cytokinesis Rho Protein Signal Transduction Regulation Of Phosphorus Metabolic Process Morphogenesis Of An Epithelium Positive Regulation Of Neuron Projection Development Regulation Of Catalytic Activity Positive Regulation Of Axonogenesis Positive Regulation Of Phospholipase Activity Regulation Of Protein Phosphorylation Cell Differentiation Positive Regulation Of Metabolic Process Wound Healing Positive Regulation Of Cell Projection Organization Positive Regulation Of Cell Cycle Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Multicellular Organismal Development Intracellular Signal Transduction Anatomical Structure Development Response To Wounding Positive Regulation Of Neuron Differentiation Cell Morphogenesis Involved In Differentiation Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Ossification Involved In Bone Maturation	Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K48-linked Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Neddylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Protein Monoubiquitination Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Protein Homooligomerization Protein K11-linked Ubiquitination Proteolysis Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Catabolic Process ISG15-protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein Oligomerization Response To Growth Factor Regulation Of Cellular Process Protein Complex Assembly DNA Replication Cellular Response To Stress Positive Regulation Of Cellular Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle MyD88-independent Toll-like Receptor Signaling Pathway
Tagcloud ?		11q23 adulthood beginning bronchi catalyzing colocalization embryogenesis exchange gastrulation gdp gtp gtpases guanine homologue incompletely intestine larg melanogaster mll morphogenesis neurite observe originally outgrowth physiologic rho rhoa undetectable vasculature	besides bioactive bioinformatics btb btbd3 candidate connectivity degs dehydrogenase dysfunctional dysregulated eicosanoid follistatin fst informatics islets latent ligases ltbp1 microrna micrornas nodes pdgfra poz prostaglandin sanguinarine t2d thiorphan zadh2
Tagcloud (Difference) ?		11q23 adulthood beginning bronchi catalyzing colocalization embryogenesis exchange gastrulation gdp gtp gtpases guanine homologue incompletely intestine larg melanogaster mll morphogenesis neurite observe originally outgrowth physiologic rho rhoa undetectable vasculature	besides bioactive bioinformatics btb btbd3 candidate connectivity degs dehydrogenase dysfunctional dysregulated eicosanoid follistatin fst informatics islets latent ligases ltbp1 microrna micrornas nodes pdgfra poz prostaglandin sanguinarine t2d thiorphan zadh2
Tagcloud (Intersection) ?