MXD1 and MLX

Number of citations of the paper that reports this interaction (PMID 10918583)
12

Data Source:
BioGRID (two hybrid)

		MXD1	MLX
Gene Name		MAX dimerization protein 1	MLX, MAX dimerization protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Transcription Corepressor Activity Protein Dimerization Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Multicellular Organismal Development Cell Proliferation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Energy Reserve Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Nucleocytoplasmic Transport Positive Regulation Of Cellular Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Transcription, DNA-templated
Pathways			Integration of energy metabolism ChREBP activates metabolic gene expression
Drugs
Diseases
GWAS			Crohn's disease ( 21102463)
Protein-Protein Interactions		18 interactors: AKT1 APP CD2 HDAC1 HDAC2 MAX MLX MYC MYCL MYCN PML PRAM1 RPS6KA1 RPS6KB1 SAP30 SIN3A SIN3B SMC3	13 interactors: AES APP GABARAPL2 ID3 MAD1L1 MLXIP MLXIPL MNT MXD1 MXD4 RBM39 SAP30BP ZBTB32
Entrez ID		4084	6945
HPRD ID		02487	04278
Ensembl ID		ENSG00000059728	ENSG00000108788
Uniprot IDs		B7ZLI7 Q05195	Q9UH92
PDB IDs		1E91 1G1E 1NLW 1PD7 1S5Q
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Response To Wounding Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Histone Deacetylation Negative Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Negative Regulation Of Biosynthetic Process Anatomical Structure Development Protein Deacetylation Response To Growth Factor Regulation Of Metabolic Process Apoptotic Process Positive Regulation Of Cellular Metabolic Process Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression, Epigenetic Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Death Response To Stress Regulation Of Cell Death Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Blood Coagulation Regulation Of Cell Differentiation Hemostasis Negative Regulation Of Nucleic Acid-templated Transcription Developmental Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Tissue Development Regulation Of Translation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Apoptotic Process Positive Regulation Of Proteolysis Negative Regulation Of Programmed Cell Death Regulation Of Body Fluid Levels System Development	Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Cell Cycle Regulation Of Cellular Process Cellular Metabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Carbohydrate Metabolic Process By Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metaphase Plate Congression Glucose Mediated Signaling Pathway Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Protein Metabolic Process Synaptic Growth At Neuromuscular Junction Regulation Of Protein Processing Carbohydrate Mediated Signaling Collateral Sprouting In Absence Of Injury Negative Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Oxidative Phosphorylation Positive Regulation Of Anoikis Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Protein Binding
Tagcloud ?		achievable bio boolean broader bromoindirubin deeper easily ets extrapolation fr180204 gsk3 implement jun mathematical modelled modelling oxime pharmacology programme prove qpcr repression rescued sp3 stimulatory su6656 telomerase tert unstable	accumulate acetyltransferase adapt bhlhzip circuitry defective fitness fundamental glucose helix homeostasis intracellular leucine mechanistic mondoa next occupancy organismal requirement respond sense simply steps stimulate stimulates transcriptionally trigger underlies zipper
Tagcloud (Difference) ?		achievable bio boolean broader bromoindirubin deeper easily ets extrapolation fr180204 gsk3 implement jun mathematical modelled modelling oxime pharmacology programme prove qpcr repression rescued sp3 stimulatory su6656 telomerase tert unstable	accumulate acetyltransferase adapt bhlhzip circuitry defective fitness fundamental glucose helix homeostasis intracellular leucine mechanistic mondoa next occupancy organismal requirement respond sense simply steps stimulate stimulates transcriptionally trigger underlies zipper
Tagcloud (Intersection) ?