CCNB2 and MCM2

Number of citations of the paper that reports this interaction (PubMedID 15232106)
0

Data Source:
HPRD (in vitro)

		CCNB2	MCM2
Description		cyclin B2	minichromosome maintenance complex component 2
Image		No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm Centrosome Microtubule Organizing Center Cytosol Microtubule Cytoskeleton Membrane	Nuclear Chromosome Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Chromosome Nucleolus Cytoplasm Cytosol Cilium MCM Complex CMG Complex
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Cadherin Binding	Nucleotide Binding DNA Binding DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Enzyme Binding Histone Binding 3'-5' DNA Helicase Activity Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Spindle Assembly Involved In Female Meiosis I G2/MI Transition Of Meiotic Cell Cycle Regulation Of Growth T Cell Homeostasis Mitotic Cell Cycle Phase Transition Thymus Development Cell Division	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Nucleosome Assembly Apoptotic Process Regulation Of DNA-templated DNA Replication Initiation Cellular Response To Interleukin-4 Cochlea Development Mitotic DNA Replication Initiation
Pathways		Polo-like kinase mediated events Golgi Cisternae Pericentriolar Stack Reorganization Resolution of Sister Chromatid Cohesion Condensation of Prometaphase Chromosomes Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Initiation of Nuclear Envelope (NE) Reformation Nuclear Pore Complex (NPC) Disassembly Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint The role of GTSE1 in G2/M progression after G2 checkpoint	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
Drugs
Diseases
GWAS		Metabolite levels ( 22916037)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Red cell distribution width ( 32888494) Refractive error ( 32231278)
Interacting Genes		7 interacting genes: CDK1 CDK2 CDKN1A CKS1B CKS2 MCM2 TGFBR2	57 interacting genes: AKAP8 APP ASF1A ATM ATR ATRIP CCNB2 CCNC CDC6 CDC7 CDK1 CDK2 CDK4 CDK6 CDKN2A CPSF1 CSNK2A1 DBF4 ELL EP300 ESCO2 FBXO7 GNB5 GTF2B GTF2H1 H3-4 KAT7 MCM10 MCM3 MCM4 MCM5 MCM6 MCM7 MCPH1 MOB4 MPP3 ORC1 ORC2 ORC4 ORC5 ORC6 P2RX4 PHB1 PHC2 PLK1 PTEN RAD52 RPA1 RPA2 RPA3 RPS4X SIK1 TBP TCEA2 TERF1 TERF2IP UBE3A
Entrez ID		9133	4171
HPRD ID		04131	00303
Ensembl ID		ENSG00000157456	ENSG00000073111
Uniprot IDs		O95067	P49736
PDB IDs			4UUZ 5BNV 5BNX 5BO0 5C3I 5JA4 6XTX 6XTY 6YA7 7CIZ 7CJ0 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 8YJF 8YJM 9CAQ
Enriched GO Terms of Interacting Partners?		Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of DNA Replication Cyclin Binding Mitotic Cell Cycle Phase Transition Fibroblast Proliferation Regulation Of Mitotic Cell Cycle Positive Regulation Of DNA Replication Cyclin-dependent Protein Kinase Activity Cell Cycle Phase Transition Mitotic DNA Damage Checkpoint Signaling Histone Kinase Activity Mitotic DNA Integrity Checkpoint Signaling G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition DNA Damage Checkpoint Signaling Regulation Of G2/M Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Regulation Of Cell Cycle G2/M Phase Transition Cell Division Regulation Of Cell Cycle Mitotic G1 DNA Damage Checkpoint Signaling Regulation Of DNA-templated DNA Replication Initiation Mitotic G1/S Transition Checkpoint Signaling DNA Replication Regulation Of DNA Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Mitotic Cell Cycle Phase Transition Histone Binding Chromosome, Telomeric Region Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Negative Regulation Of Cell Cycle Phase Transition Mitotic G2 DNA Damage Checkpoint Signaling Cell Population Proliferation Negative Regulation Of Cell Cycle Process DNA Damage Response Positive Regulation Of DNA Metabolic Process Intracellular Signaling Cassette G2/M Transition Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Cell Cycle G2/M Phase Transition Positive Regulation Of Cell Population Proliferation Regulation Of Mitotic Cell Cycle Phase Transition SCF Ubiquitin Ligase Complex Negative Regulation Of Cell Cycle Cellular Senescence Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition	DNA Metabolic Process DNA Replication DNA Replication Initiation Nucleic Acid Metabolic Process Nucleoplasm Chromosome, Telomeric Region Regulation Of DNA Replication Regulation Of DNA Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Damage Response Nucleus DNA Repair Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Recombinational Repair DNA Replication Origin Binding Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Recombination Regulation Of DNA-templated DNA Replication Initiation Regulation Of Cell Cycle Phase Transition Protein Localization To Chromosome Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Double-strand Break Repair Via Break-induced Replication Cellular Response To Stress Regulation Of Cell Cycle Process Origin Recognition Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Single-stranded DNA Binding Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Phase Transition Nuclear Origin Of Replication Recognition Complex Regulation Of Primary Metabolic Process Chromosome Chromosome Organization Cell Cycle Phase Transition CMG Complex MCM Complex Regulation Of Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Protein Localization To Site Of Double-strand Break DNA Damage Checkpoint Signaling Telomere Maintenance Response To Stress Mitotic Cell Cycle Phase Transition
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