CCNB2 and CKS1B

Number of citations of the paper that reports this interaction (PMID 19786724)
4

Data Source:
BioGRID (pull down)

		CCNB2	CKS1B
Gene Name		cyclin B2	CDC28 protein kinase regulatory subunit 1B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Centrosome Cytosol Microtubule Cytoskeleton Membrane	Nucleoplasm
	Molecular Function	Protein Binding Protein Kinase Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle In Utero Embryonic Development Mitotic Nuclear Division Mitotic Nuclear Envelope Disassembly Growth T Cell Homeostasis Thymus Development Cell Division Regulation Of Cell Cycle	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Cell Proliferation Cell Division
Pathways		Mitotic Prometaphase G2/M Checkpoints Mitotic Prophase Activation of NIMA Kinases NEK9, NEK6, NEK7 Golgi Cisternae Pericentriolar Stack Reorganization Nuclear Pore Complex (NPC) Disassembly Nuclear Envelope Breakdown G2/M Transition Regulation of PLK1 Activity at G2/M Transition Cyclin B2 mediated events M Phase Cell Cycle, Mitotic Cyclin A/B1 associated events during G2/M transition Resolution of Sister Chromatid Cohesion Cell Cycle Checkpoints Mitotic G2-G2/M phases Polo-like kinase mediated events G2/M DNA replication checkpoint Condensation of Prometaphase Chromosomes	Cyclin D associated events in G1 SCF(Skp2)-mediated degradation of p27/p21 G1/S Transition G1 Phase Cyclin E associated events during G1/S transition SCF(Skp2)-mediated degradation of p27/p21 S Phase Cyclin A:Cdk2-associated events at S phase entry Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Metabolite levels ( 22916037)	Prostate cancer ( 23535732)
Protein-Protein Interactions		7 interactors: CDK1 CDK2 CDKN1A CKS1B CKS2 MCM2 TGFBR2	34 interactors: ARID5A CCNA1 CCNA2 CCNB2 CDC27 CDC37 CDK1 CDK2 CDKN1B CDX4 CKS1BP7 CKS2 CUL1 DUSP1 HSP90AA1 IKZF1 KIAA0368 KRTAP10-9 KRTAP5-9 LDHB MEOX1 MIPOL1 PSMD9 REL ROPN1 SEPT3 SKP1 SKP2 SPERT SSBP1 SUMO1P1 TCF4 TRIM27 XIAP
Entrez ID		9133	1163
HPRD ID		04131	00299
Ensembl ID		ENSG00000157456	ENSG00000173207
Uniprot IDs		O95067	P61024 Q5T178
PDB IDs			1BUH 1DKS 1DKT 2ASS 2AST
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Process Regulation Of Phosphorylation Cell Cycle Mitotic Cell Cycle Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Kinase Activity Organ Regeneration Regulation Of Cell Cycle Mitotic DNA Damage Checkpoint Regulation Of Cellular Protein Metabolic Process Mitotic DNA Integrity Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Catalytic Activity Response To Drug DNA Damage Checkpoint Regulation Of Protein Import Into Nucleus, Translocation Mitotic Cell Cycle Checkpoint Cellular Response To Growth Factor Stimulus Response To Growth Factor Ras Protein Signal Transduction Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Positive Regulation Of Cell Proliferation Cellular Response To DNA Damage Stimulus DNA Replication Phosphorylation Positive Regulation Of Cell Cycle Histone Phosphorylation Regulation Of Cardiac Muscle Cell Proliferation Peptidyl-threonine Phosphorylation Aging Centrosome Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Heart Growth Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Cardiac Muscle Tissue Development Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of DNA Replication Regulation Of Mitotic Cell Cycle	Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle G2/M Transition Of Mitotic Cell Cycle Cell Cycle Process Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Cycle Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Positive Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Cell Division Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Mitotic Cell Cycle Checkpoint Regulation Of Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Mitotic DNA Damage Checkpoint Regulation Of Protein Kinase Activity Mitotic DNA Integrity Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Kinase Activity Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Protein Catabolic Process
Tagcloud ?		arap3 axillary bioinformatic chromatid cin25 cytoskeleton dissemination drive frameshift frozen insertions intratumoral nanoball ngs nodal node overlapping pds5b pipeline poorer progressed rearrangements segregate segregation sister snvs substitutions tgif2 top2a	axis biomarker cascade chemoresistance chemoresistant discoveries doi drive escape exerts gained immunoinhibitory inversely l1 l1highdrug mechanistic microrna mimic mir mt nsclc pd platinum programmed promotion sensitizes stat3 tumorigenicity worse
Tagcloud (Difference) ?		arap3 axillary bioinformatic chromatid cin25 cytoskeleton dissemination frameshift frozen insertions intratumoral nanoball ngs nodal node overlapping pds5b pipeline poorer progressed rearrangements segregate segregation sister snvs substitutions tgif2 top2a	axis biomarker cascade chemoresistance chemoresistant discoveries doi escape exerts gained immunoinhibitory inversely l1 l1highdrug mechanistic microrna mimic mir mt nsclc pd platinum programmed promotion sensitizes stat3 tumorigenicity worse
Tagcloud (Intersection) ?		drive