CCNB2 and CKS1B

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		CCNB2	CKS1B
Description		cyclin B2	CDC28 protein kinase regulatory subunit 1B
Image		No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm Centrosome Microtubule Organizing Center Cytosol Microtubule Cytoskeleton Membrane	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleoplasm SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Cadherin Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Histone Binding Ubiquitin Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Spindle Assembly Involved In Female Meiosis I G2/MI Transition Of Meiotic Cell Cycle Regulation Of Growth T Cell Homeostasis Mitotic Cell Cycle Phase Transition Thymus Development Cell Division	Regulation Of Mitotic Cell Cycle Cell Division
Pathways		Polo-like kinase mediated events Golgi Cisternae Pericentriolar Stack Reorganization Resolution of Sister Chromatid Cohesion Condensation of Prometaphase Chromosomes Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Initiation of Nuclear Envelope (NE) Reformation Nuclear Pore Complex (NPC) Disassembly Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint The role of GTSE1 in G2/M progression after G2 checkpoint	SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1
Drugs			Fluoxetine 2,8-bis[oxido(oxo)vanadio]-1,1,1,3,5,5,7,7,9,9,9-undecaoxopentavanadoxane-2,8-diium
Diseases
GWAS		Metabolite levels ( 22916037)	Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Prostate cancer ( 23535732)
Interacting Genes		7 interacting genes: CDK1 CDK2 CDKN1A CKS1B CKS2 MCM2 TGFBR2	57 interacting genes: ARID5A CBY2 CCDC120 CCNA1 CCNB2 CCNC CDC27 CDC37 CDK2 CDKN1B CDX4 CKS1BP7 CKS2 CT45A1 CUL1 DCDC2 DRC4 DUSP1 ECPAS HSF2BP HSP90AA1 IKZF1 IKZF3 INCA1 KPRP KRTAP10-9 KRTAP5-9 LDHB LHX3 LZTS1 MED12L MEOX1 MEOX2 MIPOL1 NR5A1 PAX5 PAX6 PPP1R13B PSMD9 REL ROPN1 SEPTIN3 SERTAD1 SERTAD2 SKP1 SKP2 SNRNP35 SSBP1 SUMO1P1 TCF12 TCF4 TRIM14 TRIM27 TRIM49C WASF3 XIAP ZBTB9
Entrez ID		9133	1163
HPRD ID		04131	00299
Ensembl ID		ENSG00000157456	ENSG00000173207
Uniprot IDs		O95067	P61024 Q5T178
PDB IDs			1BUH 1DKS 1DKT 2ASS 2AST 4YC6 7B5L 7B5M 7B5R 7NJ0 8BYA 8BYL 8OR0 8OR4
Enriched GO Terms of Interacting Partners?		Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of DNA Replication Cyclin Binding Mitotic Cell Cycle Phase Transition Fibroblast Proliferation Regulation Of Mitotic Cell Cycle Positive Regulation Of DNA Replication Cyclin-dependent Protein Kinase Activity Cell Cycle Phase Transition Mitotic DNA Damage Checkpoint Signaling Histone Kinase Activity Mitotic DNA Integrity Checkpoint Signaling G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition DNA Damage Checkpoint Signaling Regulation Of G2/M Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Regulation Of Cell Cycle G2/M Phase Transition Cell Division Regulation Of Cell Cycle Mitotic G1 DNA Damage Checkpoint Signaling Regulation Of DNA-templated DNA Replication Initiation Mitotic G1/S Transition Checkpoint Signaling DNA Replication Regulation Of DNA Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Mitotic Cell Cycle Phase Transition Histone Binding Chromosome, Telomeric Region Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Negative Regulation Of Cell Cycle Phase Transition Mitotic G2 DNA Damage Checkpoint Signaling Cell Population Proliferation Negative Regulation Of Cell Cycle Process DNA Damage Response Positive Regulation Of DNA Metabolic Process Intracellular Signaling Cassette G2/M Transition Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Cell Cycle G2/M Phase Transition Positive Regulation Of Cell Population Proliferation Regulation Of Mitotic Cell Cycle Phase Transition SCF Ubiquitin Ligase Complex Negative Regulation Of Cell Cycle Cellular Senescence Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nucleus Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Identical Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process HMG Box Domain Binding Positive Regulation Of Macromolecule Metabolic Process Cyclin A1-CDK2 Complex Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Cyclin A2-CDK2 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Protein Serine/threonine Kinase Activity SCF Ubiquitin Ligase Complex Meiosis I Cell Cycle Process Regulation Of Transcription By RNA Polymerase II Somite Specification Cytoplasm Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Cyclin Binding Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Macromolecule Metabolic Process Response To Gonadotropin-releasing Hormone Regulation Of Macromolecule Biosynthetic Process Ubiquitin Ligase Complex Scaffold Activity Meiosis I Protein Polyubiquitination Positive Regulation Of DNA Replication Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription Coregulator Binding Transcription Coactivator Activity
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