INA and GRIN2D

Number of citations of the paper that reports this interaction (PMID 10862698)
203

Data Source:
HPRD (in vivo)

		INA	GRIN2D
Gene Name		internexin neuronal intermediate filament protein, alpha	glutamate receptor, ionotropic, N-methyl D-aspartate 2D
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Neurofilament Nuclear Membrane Cytoplasmic Ribonucleoprotein Granule Intermediate Filament Cytoskeleton	Plasma Membrane N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Postsynaptic Membrane
	Molecular Function	Structural Constituent Of Cytoskeleton	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Protein Binding
	Biological Process	Substantia Nigra Development Cell Differentiation Neurofilament Cytoskeleton Organization	Startle Response Signal Transduction Synaptic Transmission Adult Locomotory Behavior Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Sensory Perception Of Pain
Pathways			Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs			L-Glutamic Acid Meperidine Orphenadrine Tenocyclidine
Diseases
GWAS		Migraine ( 22683712)
Protein-Protein Interactions		4 interactors: GRIN1 GRIN2D STAU1 TANC1	33 interactors: ABL1 CDH2 CIT CLTC CTNNB1 DLG2 DLG4 DLGAP4 DNM1 DUSP4 FUS GRIN1 HNRNPU HRAS HSPA1A IL16 INA INADL MAP2 MAP2K2 NANOS1 NF1 PPP2R1A PPP2R2A PRKCB PRKCE PRKCG RAP2A RPS6KA3 SPTAN1 SYNGAP1 TJP1 TRAF3
Entrez ID		9118	2906
HPRD ID		05628	04095
Ensembl ID		ENSG00000148798	ENSG00000105464
Uniprot IDs		Q16352	O15399 Q59G17
PDB IDs
Enriched GO Terms of Interacting Partners?		Startle Response Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Single-organism Behavior Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron-neuron Synaptic Transmission Behavior Associative Learning Adult Locomotory Behavior Propylene Metabolic Process Neuromuscular Process Learning Adult Behavior Olfactory Learning Neurological System Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Pons Maturation Locomotory Behavior Learning Or Memory Cellular Response To Manganese Ion Cognition Conditioned Taste Aversion Response To Light Stimulus Male Mating Behavior Response To Fungicide Olfactory Behavior Dendritic Spine Maintenance Intracellular MRNA Localization Pons Development Response To Radiation Chemosensory Behavior Prepulse Inhibition Response To Manganese Ion Synaptic Transmission Positive Regulation Of Viral Genome Replication Dendritic Spine Organization Myoblast Fusion Suckling Behavior Regulation Of Respiratory Gaseous Exchange Cellular Component Maintenance Regulation Of Sensory Perception Of Pain Regulation Of Long-term Neuronal Synaptic Plasticity Mating Behavior Syncytium Formation Positive Regulation Of Excitatory Postsynaptic Membrane Potential Response To Amphetamine Response To Morphine Social Behavior	Nervous System Development Regulation Of MAPK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurogenesis Cell Development Locomotion Generation Of Neurons Intracellular Signal Transduction Neuron Projection Development Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Neuronal Synaptic Plasticity Cellular Response To Stimulus Neuron Differentiation Enzyme Linked Receptor Protein Signaling Pathway Cell Projection Organization Signaling Cell Morphogenesis Involved In Differentiation Axonogenesis MyD88-independent Toll-like Receptor Signaling Pathway Neuron Development Cell Communication Apoptotic Process Response To Organic Substance Signal Transduction Axon Guidance Axon Development Programmed Cell Death Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cell Death Toll-like Receptor 4 Signaling Pathway Death Regulation Of Neuron Death Developmental Process Neuron Projection Morphogenesis Response To Ammonium Ion Immune Response-regulating Signaling Pathway Regulation Of Metabolic Process Response To Stimulus Response To Morphine Regulation Of Intracellular Signal Transduction Cell-cell Signaling Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Multicellular Organismal Development Response To External Stimulus Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process
Tagcloud ?		acylcarnitines afterdepolarizations cai2 carnitine clamp dads depolarization eliciting ether ethylene exchanger glycol inactivating incomplete inward ionic iti mv myocardium oscillations palmitoyl preceding replacing tetraacetic tetraethylammonium tetrodotoxin voltage washout	6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Difference) ?		acylcarnitines afterdepolarizations cai2 carnitine clamp dads depolarization eliciting ether ethylene exchanger glycol inactivating incomplete inward ionic iti mv myocardium oscillations palmitoyl preceding replacing tetraacetic tetraethylammonium tetrodotoxin voltage washout	6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Intersection) ?