SLC25A46 and HSD17B13

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC25A46	HSD17B13
Description		solute carrier family 25 member 46	hydroxysteroid 17-beta dehydrogenase 13
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Membrane	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol
	Molecular Function	Protein Binding Protein-containing Complex Binding	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
	Biological Process	Mitochondrial Fission Autophagy Of Mitochondrion Mitochondrial Transport Mitochondrion Organization Synapse Assembly Respiratory Chain Complex IV Assembly Dendrite Development Optic Nerve Development Cerebellar Purkinje Cell Differentiation Myelination In Peripheral Nervous System Locomotion Involved In Locomotory Behavior Cristae Formation Peripheral Nervous System Neuron Axonogenesis Establishment Of Localization In Cell Phospholipid Homeostasis Axon Development Protein-containing Complex Assembly Mitochondrial Membrane Fission	Lipid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process
Pathways			Lipid particle organization
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic sensitization ( 23817571) Asthma ( 34103634 31959851 31619474 30929738 29273806 27182965) Asthma (adult onset) ( 30929738 31036433) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Cardiac structure and function ( 19584346) Medication use (adrenergics, inhalants) ( 31015401) Medication use (antihistamines for systemic use) ( 31015401) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355) Uterine fibroid size (maximum volume) ( 30196971)	Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Bulimia nervosa ( 23568457) Cirrhosis (alcohol related) ( 32853455) Cirrhosis (multi-trait analysis) ( 33310085) Liver enzyme levels (alanine transaminase) ( 22001757) Nonalcoholic steatohepatitis ( 32298765) Platelet count ( 22139419) Rosacea symptom severity ( 29771307) Triglyceride levels ( 31928498)
Interacting Genes		16 interacting genes: AQP6 FHL3 FUNDC1 HSD17B11 HSD17B13 LEPROTL1 ODF4 REEP2 REEP4 SLC10A1 SLC10A6 SLC66A2 SLC71A2 SLC7A8 SPCS1 VMA21	129 interacting genes: ABHD16A ADGRE2 AGPAT3 AGPAT4 AGTRAP AIG1 ANKRD46 AOC3 APOA2 ARL6IP1 ATP6V0C BBC3 BMP10 BRICD5 C3orf52 CACNG1 CALHM6 CCDC167 CDIPT CLDN10 CLDN19 CLDN4 CLDND2 CMTM5 CMTM7 CYB5R3 CYBC1 CYP4F2 DIABLO EBP ECPAS FATE1 FAXDC2 FETUB GJB2 GOLM1 GOSR2 GYPB HSD3B7 IGFBP5 INSIG2 ITGAM JAGN1 LHFPL5 LPAR3 LPCAT2 LRAT MARCHF5 MGLL MIEF2 MMP14 MOSPD3 MS4A1 NAPB NAT8 NRM ORMDL3 PBX3 PLIN3 PLN PLP2 PNLIPRP1 PTPN9 RABAC1 REEP6 RHOU RPRM RUSF1 SACM1L SCAMP5 SCARF1 SCD SEC22B SERP1 SERP2 SFT2D2 SFXN1 SFXN2 SFXN3 SLC25A46 SLC30A3 SLC35B4 SLC35E4 SLC61A1 SMIM1 SNORC SPG21 ST6GAL2 STRIT1 STX5 STX7 TBRG4 TF THSD7A TIMM23 TIMMDC1 TMEM100 TMEM120A TMEM120B TMEM128 TMEM140 TMEM14B TMEM14C TMEM167B TMEM19 TMEM203 TMEM218 TMEM222 TMEM229B TMEM243 TMEM255B TMEM31 TMEM42 TMEM60 TMEM86B TMEM97 TMX2 TPRG1 TREX1 UBXN8 UNC50 VAMP2 VAMP3 VAMP4 VAMP5 VAPA VAPB YIPF2 YIPF4
Entrez ID		91137	345275
HPRD ID		14283	18023
Ensembl ID		ENSG00000164209	ENSG00000170509
Uniprot IDs		B4DY98 Q96AG3	Q7Z5P4
PDB IDs		8TMU	8G9V
Enriched GO Terms of Interacting Partners?		Steroid Dehydrogenase Activity Bile Acid:sodium Symporter Activity Bile Acid And Bile Salt Transport Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Nitrate Transmembrane Transporter Activity Membrane Taste Receptor Binding Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Endoplasmic Reticulum Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Endoplasmic Reticulum Organization Cytoplasmic Microtubule Carbon Dioxide Transmembrane Transporter Activity Transmembrane Transport Carbon Dioxide Transmembrane Transport Lipid Transport Symporter Activity Organic Anion Transport Tryptophan Transport L-alanine Transmembrane Transport L-leucine Transmembrane Transporter Activity L-leucine Import Across Plasma Membrane L-alanine Import Across Plasma Membrane Valine Transport Signal Peptidase Complex Androgen Catabolic Process Lipid Droplet Protein Transport Into Membrane Raft Sensory Perception Of Sweet Taste Sensory Perception Of Bitter Taste Vacuolar Proton-transporting V-type ATPase Complex Assembly Proline Transmembrane Transport Glycine Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity Monocarboxylic Acid Transport Toxin Transmembrane Transporter Activity Thyroid Hormone Transmembrane Transporter Activity Proton-transporting V-type ATPase Complex Assembly Monoatomic Anion Channel Activity Ammonium Channel Activity Renal Water Transport Bile Acid Transmembrane Transporter Activity L-alanine Transport	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity Serine Import Into Mitochondrion Endomembrane System SNARE Complex Monoatomic Ion Transmembrane Transporter Activity Lipid Biosynthetic Process Organelle Fusion Mitochondrial Transport Paracellular Transport Lipid Metabolic Process Vesicle-mediated Transport Glycerolipid Metabolic Process Membrane Fusion Import Into The Mitochondrion Golgi Membrane Acylglycerol Catabolic Process Golgi Vesicle Transport Serine Transport Lysophosphatidic Acid Acyltransferase Activity SNARE Complex Assembly CDP-diacylglycerol Metabolic Process Endoplasmic Reticulum Organization Vesicle Fusion Golgi Apparatus Transport Vesicle Vesicle Organization Organelle Membrane Fusion Golgi To Plasma Membrane Protein Transport FFAT Motif Binding Mitochondrial Outer Membrane Phospholipid Metabolic Process Phospholipid Biosynthetic Process 1-acylglycerol-3-phosphate O-acyltransferase Activity Sterol Biosynthetic Process Organelle Localization By Membrane Tethering Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Acylglycerol Metabolic Process Sterol Metabolic Process Bounding Membrane Of Organelle Membrane Organization Neutral Lipid Metabolic Process Response To Endoplasmic Reticulum Stress Steroid Biosynthetic Process Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules
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