SLC25A46 and SPCS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC25A46	SPCS1
Description		solute carrier family 25 member 46	signal peptidase complex subunit 1
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Membrane	Endoplasmic Reticulum Signal Peptidase Complex Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Protein-containing Complex Binding	Protein Binding
	Biological Process	Mitochondrial Fission Autophagy Of Mitochondrion Mitochondrial Transport Mitochondrion Organization Synapse Assembly Respiratory Chain Complex IV Assembly Dendrite Development Optic Nerve Development Cerebellar Purkinje Cell Differentiation Myelination In Peripheral Nervous System Locomotion Involved In Locomotory Behavior Cristae Formation Peripheral Nervous System Neuron Axonogenesis Establishment Of Localization In Cell Phospholipid Homeostasis Axon Development Protein-containing Complex Assembly Mitochondrial Membrane Fission	Signal Peptide Processing Proteolysis Virion Assembly Viral Protein Processing Protein Targeting To ER
Pathways			SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic sensitization ( 23817571) Asthma ( 34103634 31959851 31619474 30929738 29273806 27182965) Asthma (adult onset) ( 30929738 31036433) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Cardiac structure and function ( 19584346) Medication use (adrenergics, inhalants) ( 31015401) Medication use (antihistamines for systemic use) ( 31015401) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355) Uterine fibroid size (maximum volume) ( 30196971)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Feeling worry ( 29500382) Schizophrenia ( 23974872 25056061 28991256 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		16 interacting genes: AQP6 FHL3 FUNDC1 HSD17B11 HSD17B13 LEPROTL1 ODF4 REEP2 REEP4 SLC10A1 SLC10A6 SLC66A2 SLC71A2 SLC7A8 SPCS1 VMA21	9 interacting genes: AQP2 FIS1 FXYD6-FXYD2 RPRM SLC22A2 SLC25A46 TMEM74 UBXN8 YIPF2
Entrez ID		91137	28972
HPRD ID		14283	07155
Ensembl ID		ENSG00000164209	ENSG00000114902
Uniprot IDs		B4DY98 Q96AG3	A0A5F9YFS9 Q9Y6A9
PDB IDs		8TMU	7P2P 7P2Q
Enriched GO Terms of Interacting Partners?		Steroid Dehydrogenase Activity Bile Acid:sodium Symporter Activity Bile Acid And Bile Salt Transport Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Nitrate Transmembrane Transporter Activity Membrane Taste Receptor Binding Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Endoplasmic Reticulum Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Endoplasmic Reticulum Organization Cytoplasmic Microtubule Carbon Dioxide Transmembrane Transporter Activity Transmembrane Transport Carbon Dioxide Transmembrane Transport Lipid Transport Symporter Activity Organic Anion Transport Tryptophan Transport L-alanine Transmembrane Transport L-leucine Transmembrane Transporter Activity L-leucine Import Across Plasma Membrane L-alanine Import Across Plasma Membrane Valine Transport Signal Peptidase Complex Androgen Catabolic Process Lipid Droplet Protein Transport Into Membrane Raft Sensory Perception Of Sweet Taste Sensory Perception Of Bitter Taste Vacuolar Proton-transporting V-type ATPase Complex Assembly Proline Transmembrane Transport Glycine Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity Monocarboxylic Acid Transport Toxin Transmembrane Transporter Activity Thyroid Hormone Transmembrane Transporter Activity Proton-transporting V-type ATPase Complex Assembly Monoatomic Anion Channel Activity Ammonium Channel Activity Renal Water Transport Bile Acid Transmembrane Transporter Activity L-alanine Transport	Mitochondrial Fission Lumenal Side Of Membrane Polyol Transmembrane Transport Renal Water Transport Response To Water Deprivation Glycerol Transmembrane Transport Water Transmembrane Transporter Activity Cellular Response To Mercury Ion Metanephric Collecting Duct Development Cellular Response To Water Deprivation Organic Hydroxy Compound Transport Glycerol Transmembrane Transporter Activity Response To Mercury Ion Membrane Serotonin Uptake Acetylcholine Transport Histamine Uptake Pyrimidine Nucleoside Transmembrane Transporter Activity Choline Transport Norepinephrine Uptake Prostaglandin Transmembrane Transporter Activity Xenobiotic Transport Across Blood-brain Barrier Spermidine Transport Toxin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Epinephrine Transport Choline Transmembrane Transporter Activity Spermidine Transmembrane Transport Putrescine Transport Norepinephrine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Amine Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity L-arginine Import Across Plasma Membrane Putrescine Transmembrane Transporter Activity Polyamine Transmembrane Transport Thiamine Transmembrane Transport Histamine Transport L-arginine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Response To Flavonoid Response To Fluoride Negative Regulation Of Fatty Acid Transport Response To Hypobaric Hypoxia Cellular Response To Peptide Golgi Trans Cisterna Golgi Medial Cisterna Mitochondrial Membrane Fission
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?