ENPP1

Description		ectonucleotide pyrophosphatase/phosphodiesterase 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosomal Membrane Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane
	Molecular Function	Nucleic Acid Binding 3',5'-cyclic-AMP Phosphodiesterase Activity Exonuclease Activity Phosphodiesterase I Activity Dinucleotide Phosphatase Activity Scavenger Receptor Activity Insulin Receptor Binding Calcium Ion Binding Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity Phosphatase Activity Polysaccharide Binding GTP Diphosphatase Activity UTP Diphosphatase Activity Protein Homodimerization Activity Metal Ion Binding Nucleoside Triphosphate Diphosphatase Activity ATP Diphosphatase Activity 3'-phosphoadenosine 5'-phosphosulfate Binding Cyclic-GMP-AMP Hydrolase Activity
	Biological Process	Generation Of Precursor Metabolites And Energy Phosphate-containing Compound Metabolic Process Immune Response Nucleoside Triphosphate Catabolic Process Gene Expression Vesicle-mediated Transport Bone Mineralization Negative Regulation Of Cell Growth Melanocyte Differentiation Regulation Of Bone Mineralization Negative Regulation Of Bone Mineralization Inorganic Diphosphate Transport Intracellular Phosphate Ion Homeostasis Biomineral Tissue Development Cellular Response To Insulin Stimulus Response To ATP Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Glycogen Biosynthetic Process ATP Metabolic Process Negative Regulation Of D-glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Animal Organ Development 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Phosphate Ion Homeostasis Nucleic Acid Metabolic Process Negative Regulation Of Hh Target Transcription Factor Activity
Pathways		Vitamin B2 (riboflavin) metabolism Vitamin B5 (pantothenate) metabolism
Drugs		Taribavirin Polyethylene glycol 400
Diseases		Ossification of the posterior longitudinal ligament of spine (OPLL) Generalized arterial calcification of infancy Type II diabetes mellitus
GWAS		Height ( 28552196) Obesity-related traits ( 23251661)
Interacting Genes		2 interacting genes: INSR USP2
Entrez ID		5167
HPRD ID		01415
Ensembl ID		ENSG00000197594
Uniprot IDs		P22413
PDB IDs		2YS0 6WET 6WEU 6WEV 6WEW 6WFJ 8GHR
Enriched GO Terms of Interacting Partners?		Regulation Of Female Gonad Development PTB Domain Binding Insulin-like Growth Factor II Binding Exocrine Pancreas Development Regulation Of Mitotic Cell Cycle Phosphatidylinositol 3-kinase Binding Positive Regulation Of Glycolytic Process Adrenal Gland Development Sex Determination Neuron Projection Maintenance Insulin Receptor Complex Male Sex Determination Positive Regulation Of Glycogen Biosynthetic Process Insulin-like Growth Factor I Binding Neuronal Cell Body Membrane Positive Regulation Of Respiratory Burst Dendritic Spine Maintenance Regulation Of Respiratory Burst Insulin Receptor Substrate Binding Insulin-like Growth Factor Receptor Binding Positive Regulation Of Cell Cycle Positive Regulation Of Meiotic Cell Cycle Insulin Binding Insulin Receptor Activity Locomotor Rhythm Circadian Behavior Entrainment Of Circadian Clock By Photoperiod Rhythmic Behavior Cargo Receptor Activity Dendrite Membrane Positive Regulation Of Receptor Internalization Regulation Of Glycogen Biosynthetic Process Amyloid-beta Clearance Photoperiodism Entrainment Of Circadian Clock Nuclear Lumen Positive Regulation Of Protein-containing Complex Disassembly Positive Regulation Of D-glucose Import Positive Regulation Of Nitric Oxide Biosynthetic Process Dendritic Spine Organization Positive Regulation Of ATP Metabolic Process Regulation Of Cell Cycle Regulation Of Glycogen Metabolic Process Cyclin Binding Neuron Projection Organization Positive Regulation Of Nitric Oxide Metabolic Process Postsynapse Organization Positive Regulation Of D-glucose Transmembrane Transport Protein Kinase Activator Activity Positive Regulation Of Glucose Metabolic Process
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