ENPP1

Gene Name		ectonucleotide pyrophosphatase/phosphodiesterase 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Basolateral Plasma Membrane
	Molecular Function	Nucleic Acid Binding Phosphodiesterase I Activity Nucleotide Diphosphatase Activity Scavenger Receptor Activity Insulin Receptor Binding Calcium Ion Binding Protein Binding ATP Binding Zinc Ion Binding Polysaccharide Binding NADH Pyrophosphatase Activity Protein Homodimerization Activity Nucleoside-triphosphate Diphosphatase Activity 3'-phosphoadenosine 5'-phosphosulfate Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Riboflavin Metabolic Process Phosphate-containing Compound Metabolic Process Receptor-mediated Endocytosis Immune Response Nucleoside Triphosphate Catabolic Process Negative Regulation Of Ossification Negative Regulation Of Cell Growth Regulation Of Bone Mineralization Inorganic Diphosphate Transport Cellular Phosphate Ion Homeostasis Sequestering Of Triglyceride Biomineral Tissue Development Negative Regulation Of Protein Autophosphorylation Cellular Response To Insulin Stimulus Small Molecule Metabolic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Bone Remodeling 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Vitamin B2 (riboflavin) metabolism Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism
Drugs		Ribavirin Amifostine
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-protein Interactions		1 interactors: INSR
Entrez ID		5167
HPRD ID		01415
Ensembl ID		ENSG00000197594
Uniprot IDs		P22413
PDB IDs		2YS0
Enriched GO Terms of Interacting Partners?		Transformation Of Host Cell By Virus Positive Regulation Of Respiratory Burst Exocrine Pancreas Development Regulation Of Respiratory Burst Positive Regulation Of Glycolytic Process Positive Regulation Of Glycogen Biosynthetic Process Protein Heterotetramerization Male Sex Determination Modulation By Virus Of Host Morphology Or Physiology Sex Determination Regulation Of Glycolytic Process Activation Of Protein Kinase B Activity Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Metabolic Process Peptidyl-tyrosine Autophosphorylation Regulation Of Glycogen Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of Glucose Transport Regulation Of Nitric Oxide Biosynthetic Process Exocrine System Development Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Glucose Import Positive Regulation Of DNA Replication Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Reactive Oxygen Species Metabolic Process Pancreas Development Regulation Of Glucose Transport Interaction With Host Protein Tetramerization Regulation Of Glucose Metabolic Process Regulation Of Embryonic Development Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Regulation Of Protein Kinase B Signaling Regulation Of DNA Replication Positive Regulation Of Cell Division Protein Heterooligomerization Activation Of MAPK Activity Positive Regulation Of DNA Metabolic Process Insulin Receptor Signaling Pathway Digestive System Development Regulation Of Carbohydrate Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Developmental Growth Glucose Homeostasis Protein Autophosphorylation
Tagcloud ?		abundance adds backgroundtype bypass conclusionsliver contrary dimension ectonucleotide homa individuals insulin liver mellitus methodsroux modulator opportunity others phosphodiesterase presenting pyrophosphatase remission resultswe rygb signalling ss supports t2dm tolerance