ENPP1 and INSR

Number of citations of the paper that reports this interaction (PMID 10615944)
32

Data Source:
HPRD (in vivo, in vitro)

		ENPP1	INSR
Gene Name		ectonucleotide pyrophosphatase/phosphodiesterase 1	insulin receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Basolateral Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Insulin Receptor Complex Caveola Endosome Membrane Membrane Intracellular Membrane-bounded Organelle Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Nucleic Acid Binding Phosphodiesterase I Activity Nucleotide Diphosphatase Activity Scavenger Receptor Activity Insulin Receptor Binding Calcium Ion Binding Protein Binding ATP Binding Zinc Ion Binding Polysaccharide Binding NADH Pyrophosphatase Activity Protein Homodimerization Activity Nucleoside-triphosphate Diphosphatase Activity 3'-phosphoadenosine 5'-phosphosulfate Binding	Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Insulin-activated Receptor Activity Insulin-like Growth Factor Receptor Binding Protein Binding ATP Binding GTP Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding PTB Domain Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Riboflavin Metabolic Process Phosphate-containing Compound Metabolic Process Receptor-mediated Endocytosis Immune Response Nucleoside Triphosphate Catabolic Process Negative Regulation Of Ossification Negative Regulation Of Cell Growth Regulation Of Bone Mineralization Inorganic Diphosphate Transport Cellular Phosphate Ion Homeostasis Sequestering Of Triglyceride Biomineral Tissue Development Negative Regulation Of Protein Autophosphorylation Cellular Response To Insulin Stimulus Small Molecule Metabolic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Bone Remodeling 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis	Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation Heart Morphogenesis Carbohydrate Metabolic Process Regulation Of Transcription, DNA-templated G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Epidermis Development Peptidyl-tyrosine Phosphorylation Transformation Of Host Cell By Virus Signal Transduction By Phosphorylation Male Sex Determination Positive Regulation Of Cell Migration Exocrine Pancreas Development Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Cellular Response To Insulin Stimulus Peptidyl-tyrosine Autophosphorylation Glucose Homeostasis Positive Regulation Of MAPK Cascade Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of DNA Replication Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Regulation Of Embryonic Development Positive Regulation Of Glucose Import Protein Autophosphorylation Positive Regulation Of Developmental Growth Protein Heterotetramerization Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Respiratory Burst Cellular Response To Growth Factor Stimulus
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Vitamin B2 (riboflavin) metabolism Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism	Insulin receptor signalling cascade IRS activation Signal attenuation IRS-related events SHC-related events Insulin receptor recycling SHC activation Signaling by Insulin receptor
Drugs		Ribavirin Amifostine	Insulin Regular Insulin Lispro Insulin Glargine Insulin, porcine Mecasermin Insulin Aspart Insulin Detemir Insulin Glulisine Adenosine-5\'-[Beta, Gamma-Methylene]Triphosphate [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID Insulin, isophane
Diseases
GWAS		Obesity-related traits ( 23251661)	Diabetic retinopathy ( 21441570) Height ( 20881960) Hypothyroidism ( 22493691) Polycystic ovary syndrome ( 22885925) Thyroid hormone levels ( 23408906) Urate levels ( 23263486)
Protein-Protein Interactions		1 interactors: INSR	77 interactors: ACP1 ADRB2 AHSG ARF1 ARHGAP26 CALM1 CALM2 CALM3 CAV1 CAV3 CBL CEACAM1 CRK CRKL CSK DOK1 DOK4 DOK5 ENPP1 FABP4 FRS2 GAB1 GNB2L1 GRB10 GRB14 GRB7 HRAS IGF1R IGF2 INS INSRR IRF7 IRS1 IRS2 JAK1 JAK2 KHDRBS1 KRT27 KRT31 MAD2L1 MAPK3 PIK3R1 PIK3R3 PLCG1 PRKCA PRKCD PTK2 PTPN1 PTPN11 PTPN12 PTPN2 PTPN6 PTPRC PTPRF RAF1 RASA1 SH2B1 SH2B2 SHC1 SMAD2 SNX1 SNX2 SNX4 SNX6 SOCS1 SOCS2 SOCS3 SOCS6 SORBS1 SRC STAT5A STAT5B SYNCRIP TEAD1 VAV1 VAV3 YWHAB
Entrez ID		5167	3643
HPRD ID		01415	00975
Ensembl ID		ENSG00000197594	ENSG00000171105
Uniprot IDs		P22413	P06213
PDB IDs		2YS0	1GAG 1I44 1IR3 1IRK 1P14 1RQQ 2AUH 2B4S 2DTG 2HR7 2Z8C 3BU3 3BU5 3BU6 3EKK 3EKN 3ETA 3LOH 3W11 3W12 3W13 3W14 4IBM
Enriched GO Terms of Interacting Partners?		Transformation Of Host Cell By Virus Positive Regulation Of Respiratory Burst Exocrine Pancreas Development Regulation Of Respiratory Burst Positive Regulation Of Glycolytic Process Positive Regulation Of Glycogen Biosynthetic Process Protein Heterotetramerization Male Sex Determination Modulation By Virus Of Host Morphology Or Physiology Sex Determination Regulation Of Glycolytic Process Activation Of Protein Kinase B Activity Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Metabolic Process Peptidyl-tyrosine Autophosphorylation Regulation Of Glycogen Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of Glucose Transport Regulation Of Nitric Oxide Biosynthetic Process Exocrine System Development Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Glucose Import Positive Regulation Of DNA Replication Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Reactive Oxygen Species Metabolic Process Pancreas Development Regulation Of Glucose Transport Interaction With Host Protein Tetramerization Regulation Of Glucose Metabolic Process Regulation Of Embryonic Development Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Regulation Of Protein Kinase B Signaling Regulation Of DNA Replication Positive Regulation Of Cell Division Protein Heterooligomerization Activation Of MAPK Activity Positive Regulation Of DNA Metabolic Process Insulin Receptor Signaling Pathway Digestive System Development Regulation Of Carbohydrate Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Developmental Growth Glucose Homeostasis Protein Autophosphorylation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Kinase Activity Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Protein Kinase Activity Cellular Response To Organic Substance Response To Organonitrogen Compound Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Response To Hormone Cellular Response To Insulin Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Protein Phosphorylation Intracellular Signal Transduction Blood Coagulation Hemostasis Response To Insulin Response To Organic Substance Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Wound Healing Signal Transduction Immune System Process Neurotrophin TRK Receptor Signaling Pathway Innate Immune Response Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Neurotrophin Signaling Pathway Growth Hormone Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Wounding Defense Response Signaling Immune Response-regulating Signaling Pathway
Tagcloud ?		abundance adds backgroundtype bypass conclusionsliver contrary dimension ectonucleotide homa individuals insulin liver mellitus methodsroux modulator opportunity others phosphodiesterase presenting pyrophosphatase remission resultswe rygb signalling ss supports t2dm tolerance	birthweight cognate curly delays determinant dwarfing edema eliminated embryogenesis embryos epidermis generalized hypoplasia igf1r igf2 igr1r indistinguishable manifested mildly muscles nullizygotes nullizygous ossification phenotypically recognizes retardation solely thin xr
Tagcloud (Difference) ?		abundance adds backgroundtype bypass conclusionsliver contrary dimension ectonucleotide homa individuals insulin liver mellitus methodsroux modulator opportunity others phosphodiesterase presenting pyrophosphatase remission resultswe rygb signalling ss supports t2dm tolerance	birthweight cognate curly delays determinant dwarfing edema eliminated embryogenesis embryos epidermis generalized hypoplasia igf1r igf2 igr1r indistinguishable manifested mildly muscles nullizygotes nullizygous ossification phenotypically recognizes retardation solely thin xr
Tagcloud (Intersection) ?