JPT2 and EGR2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		JPT2	EGR2
Description		Jupiter microtubule associated homolog 2	early growth response 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding SUMO Ligase Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Calcium-mediated Signaling Endocytosis Involved In Viral Entry Into Host Cell	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Export From Nucleus Brain Development Peripheral Nervous System Development Rhythmic Behavior Motor Neuron Axon Guidance Gene Expression Schwann Cell Differentiation Positive Regulation Of Schwann Cell Differentiation Protein Sumoylation Rhombomere 3 Development Facial Nerve Structural Organization Rhombomere 3 Structural Organization Rhombomere 3 Formation Rhombomere 5 Structural Organization Rhombomere 5 Formation Regulation Of Ossification Positive Regulation Of Myelination Brain Segmentation Aorta Development Skeletal Muscle Cell Differentiation Myelination Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways			Transcriptional regulation of white adipocyte differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis NGF-stimulated transcription NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Adventurousness ( 30643258) Alopecia areata ( 25608926) Atopic dermatitis ( 23042114) Daytime nap ( 33568662) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Ewing sarcoma ( 22327514) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Monocyte percentage of white cells ( 32888494) Selective IgA deficiency ( 27723758) Temperament ( 22832960) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Vogt-Koyanagi-Harada syndrome ( 25108386)
Interacting Genes		8 interacting genes: CDC42 CNTFR CSNK1D EGR2 RASA4 SEPTIN2 SLC25A20 XRCC6	21 interacting genes: ACP5 BPGM DNMT3L GOLGA2 HCFC1 JPT2 MCRS1 MED31 NAB2 NDUFS2 NFATC1 PDE4DIP RBM15B RIMKLB RPL7L1 SOX10 SOX8 SRA1 UBE2I WEE2-AS1 WWP2
Entrez ID		90861	1959
HPRD ID		12674	00551
Ensembl ID		ENSG00000206053	ENSG00000122877
Uniprot IDs		A6NGP5 Q9H910	A0A8I5KYI5 P11161
PDB IDs
Enriched GO Terms of Interacting Partners?		Carnitine:O-acyl-L-carnitine Antiporter Activity O-acyl-L-carnitine Transmembrane Transporter Activity Cell Projection Assembly Plasma Membrane Bounded Cell Projection Organization Spindle Plasma Membrane Bounded Cell Projection Assembly Rhombomere 5 Structural Organization Rhombomere 3 Structural Organization Rhombomere 3 Formation Rhombomere 5 Formation O-acyl-L-carnitine Transmembrane Transport GBD Domain Binding Storage Vacuole Cell Projection Organization CNTFR-CLCF1 Complex Golgi Organization Endothelin Receptor Signaling Pathway Involved In Heart Process Ciliary Neurotrophic Factor Receptor Complex Rhombomere 3 Development Positive Regulation Of Schwann Cell Differentiation Brain Segmentation DNA End Binding Ku70:Ku80 Complex Carnitine Shuttle Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Interleukin-11 Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Binding Regulation Of Schwann Cell Differentiation Ciliary Neurotrophic Factor-mediated Signaling Pathway Cellular Hyperosmotic Salinity Response DNA-dependent Protein Kinase Complex	Negative Regulation Of Nucleobase-containing Compound Metabolic Process NSL Complex Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Enteric Nervous System Development Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Glial Cell Differentiation Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Histone Acetyltransferase Complex Positive Regulation Of RNA Biosynthetic Process MLL1 Complex Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Peripheral Nervous System Development Negative Regulation Of Myoblast Differentiation Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Superoxide Anion Generation Positive Regulation Of RNA Metabolic Process SUMO Conjugating Enzyme Activity Citrate-L-glutamate Ligase Activity N-acetyl-L-aspartate-L-glutamate Ligase Activity Oligodendrocyte Differentiation DNA-binding Transcription Factor Binding Regulation Of Gene Expression Centrosome Cycle
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