KIF4A and DNMT3B

Number of citations of the paper that reports this interaction (PMID 15148359)
36

Data Source:
BioGRID (biochemical, pull down)

		KIF4A	DNMT3B
Gene Name		kinesin family member 4A	DNA (cytosine-5-)-methyltransferase 3 beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Chromosome Cytoplasm Cytosol Kinesin Complex Spindle Microtubule Membrane Nuclear Matrix Midbody	Nucleus Nucleoplasm Nuclear Heterochromatin Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity	Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding DNA-methyltransferase Activity Unmethylated CpG Binding Metal Ion Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates
	Biological Process	Mitotic Cytokinesis Organelle Organization Microtubule-based Movement Axon Guidance Blood Coagulation Anterograde Axon Cargo Transport Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Mitotic Spindle Midzone Assembly	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Methylation-dependent Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Response To Ionizing Radiation DNA Methylation On Cytosine Within A CG Sequence Gene Expression Positive Regulation Of Gene Expression Protein Complex Localization DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Response To Drug Positive Regulation Of Neuron Differentiation Negative Regulation Of Gene Expression, Epigenetic S-adenosylhomocysteine Metabolic Process S-adenosylmethioninamine Metabolic Process Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine
Pathways		Axon guidance MHC class II antigen presentation Kinesins L1CAM interactions Recycling pathway of L1 Factors involved in megakaryocyte development and platelet production Adaptive Immune System	NoRC negatively regulates rRNA expression Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA DNA methylation
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		5 interactors: APP DNMT3B HMG20B PRC1 TTF2	35 interactors: BAZ2A CBX1 CBX3 CBX5 CMTM6 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS ZBTB18
Entrez ID		24137	1789
HPRD ID		06606	04209
Ensembl ID		ENSG00000090889	ENSG00000088305
Uniprot IDs		O95239 Q59HG1	Q9UBC3
PDB IDs			3FLG 3QKJ
Enriched GO Terms of Interacting Partners?		Regulation Of Neuron Differentiation Regulation Of Neurogenesis Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Synaptic Growth At Neuromuscular Junction Pharynx Development Regulation Of Cell Development Negative Regulation Of Protein Metabolic Process Collateral Sprouting In Absence Of Injury S-adenosylmethioninamine Metabolic Process DNA Methylation On Cytosine Within A CG Sequence Collateral Sprouting Negative Regulation Of Protein Sumoylation Axon Midline Choice Point Recognition Cellular Modified Amino Acid Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis C-5 Methylation Of Cytosine S-adenosylhomocysteine Metabolic Process Axon Choice Point Recognition Soft Palate Development Mitotic Spindle Elongation Methylation-dependent Chromatin Silencing Positive Regulation Of Neuron Differentiation Neuron Remodeling Gene Expression Hard Palate Development Positive Regulation Of Gene Expression Generation Of Neurons Negative Regulation Of Histone H3-K9 Methylation DNA Methylation On Cytosine Regulation Of Cell Differentiation Positive Regulation Of Neurogenesis Blood Coagulation MRNA Processing Neurogenesis Hemostasis Positive Regulation Of Histone H3-K4 Methylation Response To Radiation Regulation Of Protein Sumoylation Cellular Copper Ion Homeostasis Thyroid Hormone Generation Protein Complex Localization Negative Regulation Of Histone Methylation Regulation Of Transcription From RNA Polymerase II Promoter System Development Positive Regulation Of Cell Development Regulation Of Transcription, DNA-templated Copper Ion Homeostasis Suckling Behavior Regulation Of Nucleic Acid-templated Transcription	Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process DNA Modification Chromatin Modification Chromosome Organization Chromatin Silencing Chromatin Organization Gene Silencing Nucleobase-containing Compound Metabolic Process DNA Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process DNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Cellular Metabolic Process Methylation Transcription, DNA-templated Histone H3-K9 Modification Chromatin Remodeling RNA Metabolic Process DNA Methylation On Cytosine Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Histone Modification Peptidyl-lysine Modification Histone H4 Deacetylation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Rhythmic Process DNA Packaging Regulation Of Gene Expression By Genetic Imprinting Hypermethylation Of CpG Island C-5 Methylation Of Cytosine
Tagcloud ?		aba achieved adp aminobenzamide apoptosis blot cleaved cytometry doxorubicin elevated fragments inhibiting kinesin manners mb mcf mda par parp poly polymerase profound quantitated reduce ribose slightly super upregulation	cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed
Tagcloud (Difference) ?		aba achieved adp aminobenzamide apoptosis blot cleaved cytometry doxorubicin elevated fragments inhibiting kinesin manners mb mcf mda par parp poly polymerase profound quantitated reduce ribose slightly super upregulation	cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed
Tagcloud (Intersection) ?