NUDT16 and TP53BP1

Number of citations of the paper that reports this interaction (PubMedID 31911551)
48

Data Source:
BioGRID (enzymatic study)

		NUDT16	TP53BP1
Description		nudix hydrolase 16	tumor protein p53 binding protein 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Chromosome, Centromeric Region Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Nuclear Body Site Of Double-strand Break DNA Repair Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding MRNA Binding Metalloexopeptidase Activity Hydrolase Activity Nucleoside Diphosphate Phosphatase Activity Manganese Ion Binding SnoRNA Binding Chloride Ion Binding DITP Diphosphatase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Cobalt Ion Binding DIDP Phosphatase Activity RNA NAD-cap (NMN-forming) Hydrolase Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity IDP Phosphatase Activity Phosphodiesterase Decapping Endonuclease Activity	P53 Binding DNA Binding Damaged DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Telomeric DNA Binding Histone Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin-modified Histone Reader Activity Histone H4K20me2 Reader Activity Histone Reader Activity Histone H4K20me Methyltransferase Activity
	Biological Process	MRNA Catabolic Process Nucleotide Metabolic Process Sno(s)RNA Catabolic Process DITP Catabolic Process Positive Regulation Of Cell Cycle Process NAD-cap Decapping Negative Regulation Of RRNA Processing	DNA Damage Checkpoint Signaling DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Positive Regulation Of Isotype Switching Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Homooligomerization Cellular Response To X-ray Double-strand Break Repair Via Classical Nonhomologous End Joining DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Protein Localization To Site Of Double-strand Break Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Phosphate bond hydrolysis by NUDT proteins	SUMOylation of transcription factors Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS			Antibody level in response to infection ( 25758998) Apolipoprotein A1 levels ( 32203549) Cardiometabolic and hematological traits ( 27668658) Eosinophil count ( 32888494) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Liver volume ( 34128465) Lung cancer in ever smokers ( 28604730) Mean corpuscular volume ( 32888494) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 27036123)
Interacting Genes		3 interacting genes: PARP1 PRC1 TP53BP1	60 interacting genes: ANKS1A ARAP1 ATM BCL6 BLM BRCA1 BRCA2 C10orf55 CCDC120 CCNB1 CDK1 CEBPA CHEK1 CRB2 CREB5 DCLRE1A DCLRE1C DYNLL1 E2F1 EP300 GALNTL5 H2AC4 H2AX H4C1 H4C14 H4C16 HGS IFI16 KAT8 KDM1A KLHDC7B LIG4 MDC1 MEOX2 NCOA3 NEK1 NFKB1 NUDT16 OXER1 PARP1 PAXIP1 PCNT PITX1 POU6F2 PTEN RAD18 RAD50 RAD51 RBL1 RBL2 RELA SPAG9 SPOP SUMO2 TFDP1 TLX3 TP53 UBAP2 USP28 VAC14
Entrez ID		131870	7158
HPRD ID		08097	05569
Ensembl ID		ENSG00000198585	ENSG00000067369
Uniprot IDs		Q96DE0	A6NNK5 Q12888
PDB IDs		2XSQ 3COU 3MGM 5VY2 5W6X 5W6Z 5WJI 6B09 6CO2 6X7U 6X7V	1GZH 1KZY 1XNI 2G3R 2IG0 2LVM 2MWO 2MWP 3LGF 3LGL 3LH0 4CRI 4RG2 4X34 5ECG 5J26 5KGF 5Z78 5ZCJ 6CO1 6CO2 6IU7 6IUA 6MXX 6MXY 6MXZ 6MY0 6RML 6RMM 6UPT 6VA5 6VIP 7LIN 7LIO 7YQK 8EOM 8F0W 8HKW 8SVG 8SVH 8SVI 8SVJ 8SWJ 8T2D 8U4U 9CKJ
Enriched GO Terms of Interacting Partners?		Protein Localization To Site Of Double-strand Break Positive Regulation Of DNA Recombination Protein Localization To Chromosome NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity Chromosome NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Damaged DNA Binding Site Of Double-strand Break Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of DNA Metabolic Process NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Response To Ionizing Radiation Regulation Of DNA Recombination NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Regulation Of Double-strand Break Repair Positive Regulation Of Myofibroblast Differentiation Cellular Response To Radiation NAD+-protein-serine ADP-ribosyltransferase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Chromosome, Telomeric Region RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Mitotic Spindle Elongation DNA ADP-ribosylation Double-strand Break Repair Negative Regulation Of ATP Biosynthetic Process NAD DNA ADP-ribosyltransferase Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Repair Regulation Of Base-excision Repair ATP Generation From Poly-ADP-D-ribose Histone H4K20me Methyltransferase Activity Positive Regulation Of DNA Metabolic Process Transcription Pausing By RNA Polymerase II Replication Fork Reversal Spindle Elongation Histone H4K20me2 Reader Activity Positive Regulation Of Necroptotic Process Mitochondrial DNA Repair Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Contractile Ring Nuclear Body Negative Regulation Of Adipose Tissue Development Ubiquitin-modified Histone Reader Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Myofibroblast Differentiation Positive Regulation Of Mitochondrial Depolarization Regulation Of Apoptotic Signaling Pathway Mitotic Spindle Midzone Assembly	Response To Ionizing Radiation Chromatin Organization Chromosome Regulation Of Cell Cycle Phase Transition DNA Damage Response Chromosome, Telomeric Region Regulation Of Cell Cycle Process Nucleoplasm Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Phase Transition Chromatin Remodeling Negative Regulation Of Cell Cycle DNA Repair Signal Transduction In Response To DNA Damage DNA Metabolic Process Regulation Of Cell Cycle Cellular Response To Radiation DNA Binding Response To Radiation DNA Damage Checkpoint Signaling Regulation Of DNA Recombination Cellular Response To Ionizing Radiation Protein Localization To Chromosome Cellular Response To Stress Negative Regulation Of Mitotic Cell Cycle Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Double-strand Break Repair Telomere Organization DNA Recombination Nucleus Transcription Regulator Complex Site Of Double-strand Break Protein-containing Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Nucleic Acid Metabolic Process Chromosome Organization Regulation Of Nucleobase-containing Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Mitotic Cell Cycle Phase Transition Chromatin Regulation Of Cell Cycle G2/M Phase Transition Response To X-ray Regulation Of Macromolecule Metabolic Process Response To Gamma Radiation Replication Fork DNA Strand Resection Involved In Replication Fork Processing Regulation Of Primary Metabolic Process Signal Transduction By P53 Class Mediator
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