NUDT16

Description		nudix hydrolase 16
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding MRNA Binding Metalloexopeptidase Activity Hydrolase Activity Nucleoside Diphosphate Phosphatase Activity Manganese Ion Binding SnoRNA Binding Chloride Ion Binding DITP Diphosphatase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Cobalt Ion Binding DIDP Phosphatase Activity RNA NAD-cap (NMN-forming) Hydrolase Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity IDP Phosphatase Activity Phosphodiesterase Decapping Endonuclease Activity
	Biological Process	MRNA Catabolic Process Nucleotide Metabolic Process Sno(s)RNA Catabolic Process DITP Catabolic Process Positive Regulation Of Cell Cycle Process NAD-cap Decapping Negative Regulation Of RRNA Processing
Pathways		Phosphate bond hydrolysis by NUDT proteins
Drugs
Diseases
GWAS
Interacting Genes		3 interacting genes: PARP1 PRC1 TP53BP1
Entrez ID		131870
HPRD ID		08097
Ensembl ID		ENSG00000198585
Uniprot IDs		Q96DE0
PDB IDs		2XSQ 3COU 3MGM 5VY2 5W6X 5W6Z 5WJI 6B09 6CO2 6X7U 6X7V
Enriched GO Terms of Interacting Partners?		Protein Localization To Site Of Double-strand Break Positive Regulation Of DNA Recombination Protein Localization To Chromosome NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity Chromosome NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Damaged DNA Binding Site Of Double-strand Break Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of DNA Metabolic Process NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Response To Ionizing Radiation Regulation Of DNA Recombination NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Regulation Of Double-strand Break Repair Positive Regulation Of Myofibroblast Differentiation Cellular Response To Radiation NAD+-protein-serine ADP-ribosyltransferase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Chromosome, Telomeric Region RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Mitotic Spindle Elongation DNA ADP-ribosylation Double-strand Break Repair Negative Regulation Of ATP Biosynthetic Process NAD DNA ADP-ribosyltransferase Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Repair Regulation Of Base-excision Repair ATP Generation From Poly-ADP-D-ribose Histone H4K20me Methyltransferase Activity Positive Regulation Of DNA Metabolic Process Transcription Pausing By RNA Polymerase II Replication Fork Reversal Spindle Elongation Histone H4K20me2 Reader Activity Positive Regulation Of Necroptotic Process Mitochondrial DNA Repair Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Contractile Ring Nuclear Body Negative Regulation Of Adipose Tissue Development Ubiquitin-modified Histone Reader Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Myofibroblast Differentiation Positive Regulation Of Mitochondrial Depolarization Regulation Of Apoptotic Signaling Pathway Mitotic Spindle Midzone Assembly
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