CCNT2 and SUPT5H

Number of citations of the paper that reports this interaction (PubMedID 15201869)
31

Data Source:
BioGRID (enzymatic study)

		CCNT2	SUPT5H
Description		cyclin T2	SPT5 homolog, DSIF elongation factor subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cyclin/CDK Positive Transcription Elongation Factor Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm DSIF Complex
	Molecular Function	Transcription Coactivator Binding Chromatin Binding Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity RNA Polymerase Binding 7SK SnRNA Binding	Chromatin Binding RNA Binding MRNA Binding Protein Binding Enzyme Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Early Viral Transcription Late Viral Transcription Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II Host-mediated Activation Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Muscle Cell Differentiation Cell Division	Negative Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Elongation Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Positive Regulation Of Macroautophagy Regulation Of DNA-templated Transcription Elongation Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat HIV elongation arrest and recovery Pausing and recovery of HIV elongation SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes mRNA Capping RNA Polymerase II Transcription Elongation RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS		Body mass index ( 26426971) Diisocyanate-induced asthma ( 25918132) Parkinson's disease ( 28892059) Waist-to-hip ratio adjusted for BMI ( 28552196) Walking pace ( 33128006)	Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		6 interacting genes: BRD4 CDK9 HEXIM1 PKN1 RB1 SUPT5H	51 interacting genes: C9orf78 CCNH CCNT2 CDK7 CDK9 CEP55 CPSF7 CSNK2A1 DBN1 DCAF6 DSCAM EXOSC7 FHL3 GOLGA2 GTF3C1 H2AX HSPB1 HTATSF1 IK IKBKG LMAN2 MAD1L1 MAML3 MNAT1 PCBD1 PGK1 PHYHIP PIN1 PNO1 POLR2A PPIA PPP2R2D PRMT1 PRMT5 RPL9 SAP30BP SIK1 SNRNP48 SNX4 SSBP3 SUMO2 SUPT4H1 TERF1 TEX11 TLE5 XRCC5 YBX2 ZBTB3 ZFYVE9 ZNF496 ZNF512B
Entrez ID		905	6829
HPRD ID		04839	03655
Ensembl ID		ENSG00000082258	ENSG00000196235
Uniprot IDs		B4DH21 O60583	O00267
PDB IDs		2IVX	2DO3 2E6Z 2E70 3H7H 4L1U 5OHO 5OHQ 5OIK 5U98 6EQY 6ER0 6GMH 6GML 6TED 7OKX 7OKY 7OL0 7PKS 7UNC 7UND 7YCX 8A3Y 8P4C 8P4D 8P4E 8P4F 8RBX 8UHA 8UHD 8UHG 8UI0 8UIS 8W8E 8W8F 9EGX 9EGY 9EGZ 9EH0 9EH2 9J0N 9J0O 9J0P
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Negative Regulation Of DNA-templated Transcription, Elongation P-TEFb Complex Binding Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Cyclin/CDK Positive Transcription Elongation Factor Complex 7SK SnRNA Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Protein Serine/threonine Kinase Activity SnRNA Binding Chromatin Binding Nucleoplasm Negative Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Host-mediated Perturbation Of Viral Transcription Chromatin Remodeling Transcription Elongation By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-templated Transcription Elongation Positive Regulation Of RNA Metabolic Process Protein Phosphorylation Protein Serine Kinase Activity Phosphorylation Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Host-mediated Perturbation Of Viral Process Enzyme Binding Histone H4K8ac Reader Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Protein Kinase Activity P-TEFb Complex Positive Regulation Of Transcription By RNA Polymerase II Host-mediated Perturbation Of Symbiont Process Multicellular Organismal-level Homeostasis Positive Regulation Of Mitotic Cell Cycle Phase Transition DSIF Complex Histone H3K9ac Reader Activity Histone H4K5ac Reader Activity Histone H4K12ac Reader Activity PML Body Regulation Of Cellular Response To Stress Negative Regulation Of DNA-templated Transcription Nucleus Negative Regulation Of RNA Biosynthetic Process	Nucleus Nucleic Acid Metabolic Process Transcription Factor TFIIK Complex CAK-ERCC2 Complex Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Regulation Of RNA Metabolic Process DNA-templated Transcription Initiation Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex Nucleobase-containing Compound Biosynthetic Process Regulation Of Gene Expression Transcription Elongation By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Regulation Of Mitotic Cell Cycle Protein Localization To Chromosome Regulation Of Macromolecule Metabolic Process DNA-templated Transcription Elongation Protein Peptidyl-prolyl Isomerization Chromosome Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Chromosome Segregation DNA Metabolic Process Recombinational Repair Protein Localization To Site Of Double-strand Break Protein Binding DNA Recombination Transcription Pausing By RNA Polymerase II Postsynaptic Cytosol Histone H4R3 Methyltransferase Activity Peptidyl-arginine Methylation DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Anoikis Regulation Of Transcription Elongation By RNA Polymerase II Transcription Elongation-coupled Chromatin Remodeling Macromolecule Biosynthetic Process
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