NNMT

Gene Name		nicotinamide N-methyltransferase
Image
Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	Nicotinamide N-methyltransferase Activity
	Biological Process	Xenobiotic Metabolic Process Response To Organonitrogen Compound Organ Regeneration Methylation Response To Drug Small Molecule Metabolic Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Methylation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Niacin
Diseases
GWAS		Volumetric brain MRI ( 17903297)
Protein-protein Interactions		3 interactors: APP ATF6 BMF
Entrez ID		4837
HPRD ID		02478
Ensembl ID		ENSG00000166741
Uniprot IDs		P40261 Q6FH49
PDB IDs		2IIP 3ROD
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Anoikis Positive Regulation Of Protein Homooligomerization Neuron Remodeling Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Protein Oligomerization Cellular Copper Ion Homeostasis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Copper Ion Homeostasis Suckling Behavior Regulation Of Protein Kinase Activity Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Kinase Activity Regulation Of Protein Oligomerization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus RNA Polyadenylation Neuron Recognition Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hydrolase Activity Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Death Death Regulation Of Protein Phosphorylation Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Cellular Protein Metabolic Process Axon Cargo Transport Mating Neuromuscular Junction Development Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Mitotic Cell Cycle Phase Transition
Tagcloud ?		adenosylmethionine adipocyte adipocytes adipose augmenting b3 catabolism decarboxylase diacetylspermine donates expenditure flux glut4 methylates nad nicotinamide odc ornithine pao polyamine propylamine reciprocally sam sat1 spermidine spermine ssat upregulates wat