NNMT and BMF

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NNMT	BMF
Gene Name		nicotinamide N-methyltransferase	Bcl2 modifying factor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Acrosomal Vesicle Mitochondrial Outer Membrane Cytosol Plasma Membrane Myosin Complex
	Molecular Function	Nicotinamide N-methyltransferase Activity	Protein Binding
	Biological Process	Xenobiotic Metabolic Process Response To Organonitrogen Compound Organ Regeneration Methylation Response To Drug Small Molecule Metabolic Process	Apoptotic Process Positive Regulation Of Protein Homooligomerization Anoikis Positive Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Methylation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	Programmed Cell Death Activation of BH3-only proteins BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of BMF and translocation to mitochondria Intrinsic Pathway for Apoptosis
Drugs		Niacin
Diseases
GWAS		Volumetric brain MRI ( 17903297)	Dehydroepiandrosterone sulphate levels ( 21533175) Ewing sarcoma ( 22327514)
Protein-Protein Interactions		3 interactors: APP ATF6 BMF	15 interactors: BCL2 BCL2A1 BCL2L1 BCL2L2 CXCL9 DYNLL1 DYNLL2 MAPK8 MCL1 MYO5A NNMT REL SEC14L4 TCF12 TFIP11
Entrez ID		4837	90427
HPRD ID		02478	05881
Ensembl ID		ENSG00000166741	ENSG00000104081
Uniprot IDs		P40261 Q6FH49	Q96LC9
PDB IDs		2IIP 3ROD
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Anoikis Positive Regulation Of Protein Homooligomerization Neuron Remodeling Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Protein Oligomerization Cellular Copper Ion Homeostasis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Copper Ion Homeostasis Suckling Behavior Regulation Of Protein Kinase Activity Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Kinase Activity Regulation Of Protein Oligomerization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus RNA Polyadenylation Neuron Recognition Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hydrolase Activity Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Death Death Regulation Of Protein Phosphorylation Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Cellular Protein Metabolic Process Axon Cargo Transport Mating Neuromuscular Junction Development Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Mitotic Cell Cycle Phase Transition	Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Process Positive Regulation Of Mitochondrion Organization Regulation Of Signal Transduction Programmed Cell Death Cell Death Death Regulation Of Cell Death Negative Regulation Of Anoikis Regulation Of Signaling Regulation Of Anoikis Positive Regulation Of Intracellular Transport Positive Regulation Of Signal Transduction Intracellular Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Transport Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Mitochondrial Changes Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Immune System Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cellular Localization Regulation Of Neuron Death Cellular Response To Stimulus Regulation Of Establishment Of Protein Localization Response To Stimulus Response To Organic Substance Response To Cytokine Melanin Metabolic Process Positive Regulation Of Transport
Tagcloud ?		adenosylmethionine adipocyte adipocytes adipose augmenting b3 catabolism decarboxylase diacetylspermine donates expenditure flux glut4 methylates nad nicotinamide odc ornithine pao polyamine propylamine reciprocally sam sat1 spermidine spermine ssat upregulates wat	70z bcgf begin bpa call chromatographic die discrete etc glycoproteins glycosylated hcgf helper heterogeneously ig implying lymphokine lymphokines mcgf mildly permeation psf purifies purify splenic supernatants synthesize variously wehi
Tagcloud (Difference) ?		adenosylmethionine adipocyte adipocytes adipose augmenting b3 catabolism decarboxylase diacetylspermine donates expenditure flux glut4 methylates nad nicotinamide odc ornithine pao polyamine propylamine reciprocally sam sat1 spermidine spermine ssat upregulates wat	70z bcgf begin bpa call chromatographic die discrete etc glycoproteins glycosylated hcgf helper heterogeneously ig implying lymphokine lymphokines mcgf mildly permeation psf purifies purify splenic supernatants synthesize variously wehi
Tagcloud (Intersection) ?