CLIC3 and ANKRD55

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLIC3	ANKRD55
Description		chloride intracellular channel 3	ankyrin repeat domain 55
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Plasma Membrane Membrane Nuclear Body Extracellular Matrix Monoatomic Ion Channel Complex Chloride Channel Complex Extracellular Exosome
	Molecular Function	Chloride Channel Activity Protein Binding Oxidoreductase Activity Protein-disulfide Reductase (glutathione) Activity	Protein Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Signal Transduction Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport Positive Regulation Of Sprouting Angiogenesis
Pathways
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) Alzheimer's disease (cognitive decline) ( 23535033) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) IgA levels ( 28628107) IgG glycosylation ( 23382691) Immature fraction of reticulocytes ( 32888494) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lung function (FEV1) ( 30061609) Macular thickness ( 30535121) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 24076602 27386562 31604244) Optic disc size ( 31809533) Pediatric autoimmune diseases ( 26301688) Post-traumatic stress disorder ( 27167565) Reticulocyte fraction of red cells ( 32888494) Rheumatoid arthritis ( 24390342 23143596 30572963 30423114) Rheumatoid arthritis (ACPA-negative) ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Sero-negative rheumatoid arthritis ( 28706201) Serum alkaline phosphatase levels ( 33547301) Triglycerides ( 20686565) Type 1 diabetes ( 34127860) Type 2 diabetes ( 29358691 22885922 26818947 26961502 27189021 32499647 30718926 30297969 28869590) Urate levels ( 23263486) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)
Interacting Genes		35 interacting genes: AGR2 ALX1 ANKRD23 ANKRD55 APP CIMIP2B DDIT4L DNM1 EFHC2 GLYR1 INCA1 KATNBL1 KRT85 KRTAP13-3 LELP1 MAPK15 MBD3L1 MECOM MIA3 MSX2 POT1 PROSER2 SCML4 SPMIP4 SPMIP6 STMN3 TBC1D3 TBC1D3C TBC1D3K TEPSIN TLE5 VPS4A ZBTB42 ZC2HC1C ZNF620	22 interacting genes: ABI2 ANKS1A BACH2 BANP BOLA2 BOLA2B CABP5 CFAP206 CLIC3 FHL2 FHL5 FRS3 HGS HSF2BP NCK2 NOXA1 PFDN5 PTK6 TEKT4 TRIM23 ZMYND19 ZSCAN1
Entrez ID		9022	79722
HPRD ID		05941	07758
Ensembl ID		ENSG00000169583	ENSG00000164512
Uniprot IDs		O95833	Q3KP44
PDB IDs		3FY7 3KJY
Enriched GO Terms of Interacting Partners?			Cytoplasm Iron-sulfur Cluster Assembly Complex [2Fe-2S] Cluster Assembly
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