CLIC3 and MAPK15

Number of citations of the paper that reports this interaction (PMID 9880541)
19

Data Source:
HPRD (in vivo)

		CLIC3	MAPK15
Gene Name		chloride intracellular channel 3	mitogen-activated protein kinase 15
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Chloride Channel Complex Extracellular Vesicular Exosome	Extracellular Region Intracellular Nucleus
	Molecular Function	Voltage-gated Ion Channel Activity Chloride Channel Activity Protein Binding	MAP Kinase Activity ATP Binding SH3 Domain Binding
	Biological Process	Chloride Transport Signal Transduction Regulation Of Ion Transmembrane Transport Chloride Transmembrane Transport	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Positive Regulation Of Protein Phosphorylation Negative Regulation Of DNA Replication Positive Regulation Of Protein Ubiquitination Response To Estradiol Positive Regulation Of Protein Catabolic Process Protein Autophosphorylation
Pathways
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: APP DNM1 EFHC2 MAPK15 POT1	8 interactors: CLIC3 CSK GABARAP GABARAPL1 MBP NR3C1 SRC TGFB1I1
Entrez ID		9022	225689
HPRD ID		05941	16867
Ensembl ID			ENSG00000181085
Uniprot IDs		O95833	Q8TD08
PDB IDs		3FY7 3KJY
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Replication Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Strand Elongation Regulation Of DNA Replication Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Telomere Formation Via Telomerase Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Telomere Capping Positive Regulation Of Helicase Activity Negative Regulation Of Telomere Maintenance Via Telomerase Axon Choice Point Recognition Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Neuron Remodeling Axon Guidance Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Negative Regulation Of Cellular Metabolic Process Axonogenesis Cellular Copper Ion Homeostasis Regulation Of Telomere Maintenance Positive Regulation Of DNA Biosynthetic Process Axon Development Cell Morphogenesis Involved In Neuron Differentiation RNA-dependent DNA Replication Chemotaxis Copper Ion Homeostasis Suckling Behavior Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Projection Morphogenesis Endocytosis Positive Regulation Of Cellular Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Telomere Maintenance Via Telomere Lengthening Endosome Organization Cell Morphogenesis Involved In Differentiation Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation	Intracellular Steroid Hormone Receptor Signaling Pathway Cell Communication Morphogenesis Of An Epithelium Nucleophagy Intracellular Receptor Signaling Pathway Tissue Morphogenesis Mitochondrion Degradation Regulation Of Bone Resorption Organelle Disassembly Peptidyl-tyrosine Autophosphorylation Regulation Of Bone Remodeling Autophagic Vacuole Assembly Membrane Organization Response To Progesterone Response To Hormone Macroautophagy Mammary Gland Duct Morphogenesis Response To Stress Regulation Of Tissue Remodeling Response To Stimulus Response To Fatty Acid Epithelium Development Negative Regulation Of Signal Transduction Signaling T Cell Costimulation Response To Nutrient Levels Mammary Gland Morphogenesis Glucocorticoid Mediated Signaling Pathway Adherens Junction Organization Negative Regulation Of Signaling Response To Extracellular Stimulus Response To Steroid Hormone Mammary Gland Epithelium Development Regulation Of Glucose Metabolic Process Vacuole Organization Regulation Of Cytokine Production Cellular Response To Progesterone Stimulus Cellular Response To Hormone Stimulus Cellular Response To Stimulus Membrane Fusion Cellular Response To Starvation Defense Response To Nematode Negative Regulation Of Glucocorticoid Mediated Signaling Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Carbohydrate Metabolic Process Gland Morphogenesis Autophagy Epidermal Growth Factor Receptor Signaling Pathway Response To Corticosteroid ERBB Signaling Pathway
Tagcloud ?		acini acquire alpha5beta1 basement cargo com compartments concert correspondingly drives endosomal endosomes integrin invasiveness matrigel mcf10dcis metalloproteinase mmp mmp14 mt1 opposes organotypic plane plugs predicts rab25 recycling trafficking transferred	atypical autonomous autonomously biogenesis consequently coordinates delay dilp dilps drosophila effector epistatically erk7 erk8 humoral impede ipcs larval limiting neurosecretory nutrient nutrition operates ribosome secreting secretion starvation surveillance uncover
Tagcloud (Difference) ?		acini acquire alpha5beta1 basement cargo com compartments concert correspondingly drives endosomal endosomes integrin invasiveness matrigel mcf10dcis metalloproteinase mmp mmp14 mt1 opposes organotypic plane plugs predicts rab25 recycling trafficking transferred	atypical autonomous autonomously biogenesis consequently coordinates delay dilp dilps drosophila effector epistatically erk7 erk8 humoral impede ipcs larval limiting neurosecretory nutrient nutrition operates ribosome secreting secretion starvation surveillance uncover
Tagcloud (Intersection) ?