SBDS and CLN3

Number of citations of the paper that reports this interaction (PMID 20015955)
7

Data Source:
BioGRID (two hybrid)

		SBDS	CLN3
Gene Name		Shwachman-Bodian-Diamond syndrome	ceroid-lipofuscinosis, neuronal 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm	Golgi Membrane Nucleus Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Early Endosome Late Endosome Autophagic Vacuole Endoplasmic Reticulum Golgi Apparatus Golgi Stack Trans-Golgi Network Plasma Membrane Caveola Synaptic Vesicle Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Neuron Projection Membrane Raft
	Molecular Function	Protein Binding Microtubule Binding RRNA Binding Ribosome Binding Poly(A) RNA Binding	Protein Binding Unfolded Protein Binding
	Biological Process	Inner Cell Mass Cell Proliferation RRNA Processing Cell Proliferation Bone Mineralization Leukocyte Chemotaxis Mature Ribosome Assembly Ribosomal Large Subunit Biogenesis Mitotic Spindle Stabilization Bone Marrow Development	Autophagic Vacuole Fusion Action Potential Globoside Metabolic Process Cellular Amino Acid Metabolic Process Ceramide Metabolic Process Glucosylceramide Metabolic Process Galactosylceramide Metabolic Process Sphingomyelin Metabolic Process Receptor-mediated Endocytosis Vacuolar Transport Lysosome Organization Lysosomal Lumen Acidification Associative Learning Arginine Transport Macroautophagy Negative Regulation Of Macroautophagy Protein Processing Protein Catabolic Process Ionotropic Glutamate Receptor Signaling Pathway Lysosomal Lumen PH Elevation Neurotransmitter Metabolic Process Amyloid Precursor Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Proteolysis Vesicle Transport Along Microtubule Neuromuscular Process Controlling Balance Cytosolic Calcium Ion Homeostasis Membrane Organization
Pathways
Drugs
Diseases
GWAS			Inflammatory bowel disease (early onset) ( 19915574)
Protein-Protein Interactions		5 interactors: ACD CLN3 POT1 TERF1 TERF2IP	2 interactors: KCNIP3 SBDS
Entrez ID		51119	1201
HPRD ID		07393	08450
Ensembl ID		ENSG00000126524	ENSG00000188603
Uniprot IDs		Q9Y3A5	B4DFF3 Q13286
PDB IDs		2KDO 2L9N
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Regulation Of Telomerase Activity RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Telomere Assembly Protection From Non-homologous End Joining At Telomere Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Telomerase Activity Homeostatic Process Regulation Of DNA Replication Negative Regulation Of Telomerase Activity Negative Regulation Of Cellular Metabolic Process Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Biosynthetic Process Regulation Of Organelle Organization Protein Localization To Chromosome DNA Replication Chromosome Organization DNA Metabolic Process Organelle Organization Positive Regulation Of DNA Replication Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation Lysosomal Lumen PH Elevation Negative Regulation Of DNA Recombination At Telomere Regulation Of Cellular Component Organization Negative Regulation Of Catalytic Activity Positive Regulation Of DNA Metabolic Process Globoside Metabolic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Cellular Nitrogen Compound Metabolic Process Regulation Of Catalytic Activity Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Formation Via Telomerase Nitrogen Compound Metabolic Process Telomere Maintenance Via Telomere Shortening Lysosomal Lumen Acidification Regulation Of Lysosomal Lumen PH	Mitotic Spindle Stabilization Spindle Stabilization Bone Marrow Development Mature Ribosome Assembly Regulation Of Mitotic Spindle Organization Behavioral Response To Pain Inner Cell Mass Cell Proliferation Ribosomal Large Subunit Biogenesis Blastocyst Growth Ribosome Assembly Negative Regulation Of Microtubule Depolymerization Response To Pain Negative Regulation Of Microtubule Polymerization Or Depolymerization Bone Mineralization
Tagcloud ?		ancestral aromatic arose catalyzed centrally confer consists corresponds duplication heterotrimeric homotetrameric inactivates lethal mystery notion p13 p36 p69 photocross protomer refer rpa ssb ssbs ssdna stably tetrameric wrapping	associates breakdown cerevisiae chaperone cln2 close defect degradation degraded dnaj folding g1 h1 homolog inactivation nonpermissive p34cdc28 phosphorylation proper proteasome proximity pure reconstitution saccharomyces seems segment sis1 triggered ydj1
Tagcloud (Difference) ?		ancestral aromatic arose catalyzed centrally confer consists corresponds duplication heterotrimeric homotetrameric inactivates lethal mystery notion p13 p36 p69 photocross protomer refer rpa ssb ssbs ssdna stably tetrameric wrapping	associates breakdown cerevisiae chaperone cln2 close defect degradation degraded dnaj folding g1 h1 homolog inactivation nonpermissive p34cdc28 phosphorylation proper proteasome proximity pure reconstitution saccharomyces seems segment sis1 triggered ydj1
Tagcloud (Intersection) ?