KCNK17 and BBS2

Data Source: HiPPIP (Novel)

		KCNK17	BBS2
Name		potassium two pore domain channel subfamily K member 17	Bardet-Biedl syndrome 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Monoatomic Ion Channel Complex	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microvillus Cilium Membrane Motile Cilium Stereocilium Centriolar Satellite BBSome Ciliary Basal Body Cell Projection Neuron Projection Ciliary Membrane
	Molecular Function	Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Ion Leak Channel Activity Metal Ion Binding Protein Heterodimerization Activity	Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport	Sperm Axoneme Assembly Visual Perception Intracellular Protein Localization Gene Expression Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Protein Transport Striatum Development Hippocampus Development Cerebral Cortex Development Cell Projection Organization Adult Behavior Melanosome Transport Leptin-mediated Signaling Pathway Protein Localization To Organelle Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Vasodilation Golgi To Plasma Membrane Protein Transport Response To Leptin Fat Cell Differentiation Photoreceptor Cell Maintenance Brain Morphogenesis Cartilage Development Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Non-motile Cilium Assembly
Pathways		TWIK-related alkaline pH activated K+ channel (TALK) Phase 4 - resting membrane potential	BBSome-mediated cargo-targeting to cilium
Diseases		None	Bardet-Biedl syndrome (BBS)
GWAS		Apolipoprotein B levels ( 32203549 ) Cholesterol, total ( 24097068 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: BBS2	10 novel interactors: APOC2 CES1 CETP CNOT1 GOT2 HSF4 KCNK17 MAP2K5 SPTSSA WRNIP1
Interacting Genes		1 interacting genes: VKORC1	17 interacting genes: BHMT EEF1A1 EPAS1 EXOC7 FHOD1 FNDC3B HNRNPF HSCB KRT18 LMO4 MDFI NRF1 PAX2 PJA2 PSME3 RBPMS UBC
Entrez ID		89822	583
HPRD ID		09566	05855
Ensembl ID		ENSG00000124780	ENSG00000125124
Uniprot IDs		Q96T54	A0A804HIE1 A0A804HKG1 Q9BXC9
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Tonic Smooth Muscle Contraction Artery Smooth Muscle Contraction Regulation Of Cilium Beat Frequency BBSome Negative Regulation Of Appetite Negative Regulation Of Multicellular Organism Growth Vascular Associated Smooth Muscle Contraction Striatum Development Leptin-mediated Signaling Pathway Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Quinone Binding Peptidyl-glutamic Acid Modification Vitamin K Metabolic Process Regulation Of Response To Food Pigment Granule Localization Establishment Of Melanosome Localization Melanosome Localization Response To Leptin Brain Morphogenesis Melanosome Transport Pigment Granule Transport Regulation Of Appetite Sperm Axoneme Assembly Positive Regulation Of Coagulation Vasoconstriction Positive Regulation Of Multicellular Organism Growth Regulation Of Response To Nutrient Levels Golgi To Plasma Membrane Protein Transport Regulation Of Cilium Movement Photoreceptor Cell Maintenance Stereocilium Smooth Muscle Contraction Non-motile Cilium Assembly Regulation Of Microtubule-based Movement Vasodilation Axoneme Assembly Animal Organ Development Ciliary Membrane Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Regulation Of Multicellular Organism Growth Microvillus Hippocampus Development Bone Development Positive Regulation Of Multicellular Organismal Process	Reverse Cholesterol Transport Very-low-density Lipoprotein Particle Remodeling Centriolar Satellite Cholesterol Transport Triglyceride-rich Lipoprotein Particle Remodeling Regulation Of Cholesterol Transport Regulation Of Primary Metabolic Process Sterol Transport Sterol Homeostasis Cholesterol Homeostasis Microtubule Organizing Center