RCAN1 and KCNE1

Data Source: HiPPIP (Novel)

		RCAN1	KCNE1
Name		regulator of calcineurin 1	potassium voltage-gated channel subfamily E regulatory subunit 1
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Lysosome Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Apical Plasma Membrane Z Disc Monoatomic Ion Channel Complex Membrane Raft
	Molecular Function	Nucleic Acid Binding Protein Phosphatase Inhibitor Activity Protein Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Identical Protein Binding	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Telethonin Binding Transmembrane Transporter Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Response To Ischemia Response To Stress Response To Oxidative Stress Skeletal Muscle Tissue Development Short-term Memory Response To Mechanical Stimulus Calcium-mediated Signaling Locomotion Involved In Locomotory Behavior Calcineurin-NFAT Signaling Cascade Response To Estrogen Skeletal Muscle Fiber Development Negative Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Calcineurin-NFAT Signaling Cascade	Epithelial Cell Maturation Monoatomic Ion Transport Potassium Ion Transport Sensory Perception Of Sound Vestibular Nucleus Development Secretory Granule Organization Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Regulation Of Potassium Ion Transport Heart Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To CAMP Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Protein Targeting To Membrane Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways		None	Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs		Dipyridamole	Enflurane Promethazine Miconazole Azimilide
Diseases		None	Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Cancer ( 29299148 ) Rheumatoid arthritis ( 23143596 24390342 30423114 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676 )	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits ( 20062063 ) Electrocardiographic traits (multivariate) ( 32602732 ) Hippocampal volume ( 29274321 ) L-selectin levels ( 25576479 ) Long QT syndrome ( 32429735 ) QT interval ( 24952745 29213071 30679814 31217584 )
Novel Interactors		7 novel interactors: ATP5PO CBR3 DSCAM IL10RB ITSN1 KCNE1 SON	3 novel interactors: CBR3 KCNJ15 RCAN1
Interacting Genes		22 interacting genes: APP BTRC CXXC5 E2F3 GSK3B MAP3K3 MAPK3 NEUROD2 PICK1 PPP3CA PPP3CB PPP3R1 PRDM4 PTPRD SF3A2 SOX10 SOX9 SPARCL1 USP22 UXT ZNF292 ZNF350	6 interacting genes: ADRB2 KCNH2 KCNQ1 PRKCA TPM3 UBASH3A
Entrez ID		1827	3753
HPRD ID		04226	01442
Ensembl ID		ENSG00000159200	ENSG00000180509
Uniprot IDs		B7Z1F0 E9PDJ2 P53805 Q6FGP2 Q6ZMM3 V9GYW9	A7LFK2 A7LFK4 C7S316 P15382 Q6FHJ6
PDB IDs		6UUQ	2K21
GO Terms Enriched among Interactors		Regulation Of Calcium-mediated Signaling Modulation Of Chemical Synaptic Transmission Positive Regulation Of Calcium-mediated Signaling Regulation Of Transcription By RNA Polymerase II Glial Cell Development Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Positive Regulation Of Cellular Component Organization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Calcineurin-NFAT Signaling Cascade Protein Serine/threonine Phosphatase Complex Regulation Of Calcineurin-mediated Signaling Positive Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Glutamatergic Synapse Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-NFAT Signaling Cascade Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Intracellular Signaling Cassette Cell Development Regulation Of Endocytosis Positive Regulation Of Calcium Ion Import Protein Dimerization Activity Calcineurin-mediated Signaling Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Synaptic Plasticity Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Monoatomic Ion Transport Regulation Of Vesicle-mediated Transport Calmodulin-dependent Protein Phosphatase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Biosynthetic Process Negative Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport	System Process Potassium Ion Import Across Plasma Membrane Muscle Contraction Muscle System Process Potassium Channel Activity Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Ventricular Cardiac Muscle Cell Membrane Repolarization Inorganic Cation Import Across Plasma Membrane Potassium Ion Export Across Plasma Membrane Adrenergic Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Import Across Plasma Membrane Potassium Ion Transmembrane Transport Membrane Repolarization During Action Potential Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Delayed Rectifier Potassium Channel Activity Monoatomic Ion Channel Complex Renal Sodium Ion Absorption Inward Rectifier Potassium Channel Activity Renal Sodium Ion Transport Positive Regulation Of Potassium Ion Transmembrane Transport Potassium Ion Transport Membrane Repolarization Negative Regulation Of Potassium Ion Transport Regulation Of System Process Response To Mechanical Stimulus Positive Regulation Of Potassium Ion Transport Regulation Of Membrane Repolarization Metal Ion Transport Cardiac Muscle Cell Action Potential Involved In Contraction Potassium Ion Homeostasis Import Into Cell Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Cardiac Muscle Contraction Renal Absorption Regulation Of Muscle System Process Cardiac Conduction Voltage-gated Potassium Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Monoatomic Cation Transport Export Across Plasma Membrane Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Cognition Regulation Of Potassium Ion Transmembrane Transport