FRK and PRDM1

		FRK	PRDM1
Description		fyn related Src family tyrosine kinase	PR/SET domain 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Histone Methyltransferase Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Pattern Recognition Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation Symbiont-mediated Suppression Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Innate Immune Response	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Morphogenesis Of A Branching Structure Kidney Development Embryonic Placenta Development Maternal Placenta Development Adaptive Immune Response Immune System Process Heart Valve Development Cardiac Septum Development Ventricular Septum Development Regulation Of Transcription By RNA Polymerase II Germ Cell Development Post-embryonic Development Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Methylation Regulation Of Natural Killer Cell Differentiation Regulation Of Extrathymic T Cell Differentiation Aorta Development Regulation Of Cell Population Proliferation Eye Photoreceptor Cell Development Innate Immune Response Cell Fate Commitment Artery Morphogenesis Cellular Developmental Process Regulation Of NK T Cell Differentiation Retinal Bipolar Neuron Differentiation Intestinal Epithelial Cell Development Trophoblast Giant Cell Differentiation Coronary Vasculature Development Sebum Secreting Cell Proliferation
Pathways		Neutrophil degranulation Regulation of PTEN stability and activity	Regulation of TP53 Expression STAT3 nuclear events downstream of ALK signaling Specification of primordial germ cells
Drugs		Dasatinib Regorafenib Fostamatinib Zanubrutinib
Diseases
GWAS		Age-related macular degeneration ( 21665990) Alanine aminotransferase levels ( 34315874 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 28724990) Aspartate aminotransferase levels ( 34315874 33547301) C-reactive protein levels ( 30388399) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 20686565 24097068) Choroid plexus volume ( 31530798) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Diastolic blood pressure ( 27841878) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) HDL cholesterol levels ( 32203549 30698716) High density lipoprotein cholesterol levels ( 33339817) HOMA-B (corrected for HOMA-IR) ( 30369944) LDL cholesterol ( 24097068 20686565) LDL cholesterol levels ( 28334899 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Longevity ( 30294719) Low density lipoprotein cholesterol levels ( 32154731) Photic sneeze reflex ( 27182965) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Total cholesterol levels ( 28334899) Urate levels ( 23263486)	Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463) Diastolic blood pressure ( 30224653) Monobrow ( 27182965) Multiple myeloma ( 27363682) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261) Sjögren's syndrome ( 24097067) Systemic lupus erythematosus ( 33272962 19838193 28714469 27399966 26502338 23273568 19838195) Systemic sclerosis ( 28314753) Triglyceride levels ( 32203549)
Interacting Genes		6 interacting genes: BNIP2 EGFR KHDRBS1 RB1 SF3B4 SKAP2	14 interacting genes: ATXN1 CFTR H1-1 H3C15 HNF1B IKZF3 IRF4 KDM1A NFIC NFIX PIAS1 TLE1 TLE2 TLE5
Entrez ID		2444	639
HPRD ID		05954	04572
Ensembl ID		ENSG00000111816	ENSG00000057657
Uniprot IDs		P42685	A0A3B3IU23 B4DW27 O75626 Q5T4E8
PDB IDs			3DAL
Enriched GO Terms of Interacting Partners?		Epithelial Cell Proliferation Embryonic Placenta Development Neuron Differentiation Sebum Secreting Cell Proliferation Regulation Of Cell Population Proliferation Embryonic Organ Development Cell Population Proliferation Regulation Of NK T Cell Differentiation Regulation Of Cell Differentiation Regulation Of Extrathymic T Cell Differentiation Striated Muscle Cell Differentiation Regulation Of Programmed Cell Death Muscle Cell Differentiation Regulation Of Apoptotic Process Regulation Of Protein Kinase C Signaling Positive Regulation Of Mitotic Cell Cycle Phase Transition Kinase Binding Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Epidermal Growth Factor Binding Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Cell Morphogenesis Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Multivesicular Body, Internal Vesicle Lumen Negative Regulation Of Myofibroblast Differentiation Mitotic Cell Cycle Phase Transition Sister Chromatid Biorientation Cell Cycle G1/S Phase Transition Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Lipid Kinase Activity Negative Regulation Of Hepatocyte Apoptotic Process G1/S Transition Of Mitotic Cell Cycle Glial Cell Apoptotic Process Rb-E2F Complex Regulation Of Centromere Complex Assembly Chromatin Lock Complex Cell Cycle Phase Transition Positive Regulation Of Collagen Fibril Organization Splicing Factor Binding Positive Regulation Of RNA Export From Nucleus Grb2-Sos Complex Enucleate Erythrocyte Differentiation ERBB2-EGFR Signaling Pathway Cyclin/CDK Positive Transcription Elongation Factor Complex Retinal Bipolar Neuron Differentiation Maternal Placenta Development Developmental Process Involved In Reproduction	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Nucleus Regulation Of Primary Metabolic Process Transcription Corepressor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Promoter-specific Chromatin Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cis-regulatory Region Sequence-specific DNA Binding Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Animal Organ Morphogenesis DNA Binding Nucleosome Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Anoikis Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of DNA Recombination Positive Regulation Of RNA Metabolic Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Regulation Of Programmed Cell Death Negative Regulation Of Wnt Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Signaling Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity
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