FOXP2 and ZMYM2

Number of citations of the paper that reports this interaction (PubMedID 29365100)
0

Data Source:
BioGRID (fluorescent resonance energy transfer)

		FOXP2	ZMYM2
Description		forkhead box P2	zinc finger MYM-type containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Cytosol PML Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding	Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Post-embryonic Development Gene Expression Cerebellum Development Cerebellar Purkinje Cell Differentiation Caudate Nucleus Development Putamen Development Cerebral Cortex Development Lung Development Vocal Learning Camera-type Eye Development Negative Regulation Of DNA-templated Transcription Lung Alveolus Development Animal Organ Development Smooth Muscle Tissue Development Positive Regulation Of Epithelial Cell Proliferation Righting Reflex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Epithelial Cell Proliferation Involved In Lung Morphogenesis Vocalization Behavior	Negative Regulation Of DNA-templated Transcription
Pathways		Positive Regulation of CDH1 Gene Transcription	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins Negative Regulation of CDH1 Gene Transcription
Drugs
Diseases		Speech-language disorder 1 (SPCH1)
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Age at first birth ( 34211149 27798627) Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder ( 30478444) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Beard thickness ( 26926045) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 28892062 25673413) Brain morphology (MOSTest) ( 32665545) Cannabis use disorder ( 33096046) Childhood maltreatment ( 32066696) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Congenital heart disease (maternal effect) ( 28468790) Conotruncal heart defects (maternal effects) ( 28468790) Crohn's disease ( 22936669) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Drug experimentation measurement ( 30718321) Feeling tense ( 29500382) Fish- and plant-related diet ( 32066663) Frailty index ( 34431594) Gastroesophageal reflux disease ( 31527586) General risk tolerance (MTAG) ( 30643258) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Insomnia ( 32332799) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Irritable mood ( 29500382) Major depressive disorder (MTAG) ( 33479212) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Multisite chronic pain ( 33830993 31194737) Neuroticism ( 29255261) Number of sexual partners ( 30643258) Pelvic organ prolapse (moderate/severe) ( 26545240) Schizophrenia, bipolar disorder or recurrent major depressive disorder ( 34099189) Self-reported risk-taking behaviour ( 30181555 30271922) Serum sulfate level ( 27412988) Sleep duration ( 27992416) Sleep duration (short sleep) ( 30846698) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Subcortical volume (MOSTest) ( 32665545) Urate levels in obese individuals ( 25811787) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Weight ( 28552196)	Adult body size ( 32376654) Facial emotion recognition (happy faces) ( 28608620) Hand grip strength ( 29691431)
Interacting Genes		22 interacting genes: CCNC CDK3 FAM124A FOXP1 FOXP4 LNX1 MAPK3 NR2F1 NR2F2 PIAS3 PIN1 RPIA SATB1 SATB2 SDCBP SOX5 SP4 TBR1 TLE5 TSACC YY1 ZMYM2	32 interacting genes: CEBPE CRBN CREB1 CREBBP ERG FBXL17 FOXP1 FOXP2 FOXP4 FUS GMCL1 HNRNPA2B1 HNRNPH3 IKZF3 PAICS PTBP1 SFPQ SKIL SLC19A4P SMAD3 SMAD4 SNIP1 SREBF2 SUMO1 SUMO2 SUMO3 TSC22D2 UBE2A UBE2I UBTF ZBTB3 ZNF512B
Entrez ID		93986	7750
HPRD ID		05611	03745
Ensembl ID		ENSG00000128573	ENSG00000121741
Uniprot IDs		B7ZLK5 O15409 Q8N6B5 Q8N6B6 X5D2H2	A8K126 Q9UBW7
PDB IDs		2A07 2AS5
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Caveolar Macromolecular Signaling Complex DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process G0 To G1 Transition Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Caveolin-mediated Endocytosis Chromatin Regulation Of Metabolic Process Caveola Assembly Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II Plasma Membrane Raft Assembly Receptor-mediated Endocytosis Of Virus By Host Cell Membrane Raft Assembly Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Nucleus Regulation Of Locomotion Plasma Membrane Raft Organization Endocytosis Involved In Viral Entry Into Host Cell Caveola DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Zinc Ion Binding Cartilage Development Acrosomal Membrane Negative Regulation Of Cardiac Muscle Tissue Growth Regulation Of Anoikis	Nucleoplasm Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Presynaptic Cytosol Postsynaptic Cytosol RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding PML Body Chromatin Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding Negative Regulation Of Macromolecule Biosynthetic Process Protein Sumoylation Protein Tag Activity Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transforming Growth Factor Beta3 Production Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Macromolecule Metabolic Process Regulation Of MiRNA Transcription Ubiquitin-like Protein Ligase Binding Regulation Of MiRNA Metabolic Process Positive Regulation Of Metabolic Process MiRNA Processing Small Protein Activating Enzyme Binding Transforming Growth Factor Beta Receptor Signaling Pathway Identical Protein Binding
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