EIF2B4 and EIF2B2

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (two hybrid, biochemical)
HPRD (in vivo, in vitro)

		EIF2B4	EIF2B2
Gene Name		eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa	eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding S-methyl-5-thioribose-1-phosphate Isomerase Activity	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding GTP Binding S-methyl-5-thioribose-1-phosphate Isomerase Activity
	Biological Process	Ovarian Follicle Development Translation Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Response To Heat Response To Glucose Gene Expression Oligodendrocyte Development L-methionine Biosynthetic Process From Methylthioadenosine Negative Regulation Of Translational Initiation In Response To Stress Myelination Response To Peptide Hormone Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process Negative Regulation Of Translational Initiation Cellular Response To Stimulus	Ovarian Follicle Development Translation Translational Initiation Regulation Of Translational Initiation Central Nervous System Development Response To Heat Response To Glucose Gene Expression Oligodendrocyte Development L-methionine Biosynthetic Process From Methylthioadenosine Myelination Response To Peptide Hormone Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process Cellular Response To Stimulus
Pathways		Recycling of eIF2:GDP Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation	Recycling of eIF2:GDP Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: EIF2B2 EIF2B5 EIF2S1 EIF2S2	10 interactors: APP C9orf72 CCT3 CSNK2A2 EIF2B1 EIF2B4 EIF2B5 EIF2S1 MRFAP1L1 NCK1
Entrez ID		8890	8892
HPRD ID		09459	05923
Ensembl ID		ENSG00000115211	ENSG00000119718
Uniprot IDs		Q9UI10	P49770 Q53XC2
PDB IDs
Enriched GO Terms of Interacting Partners?		Translational Initiation Regulation Of Translational Initiation Translation Regulation Of Translational Initiation In Response To Stress Regulation Of Translation In Response To Stress Gonad Development Development Of Primary Sexual Characteristics Regulation Of Translation Sex Differentiation Oligodendrocyte Development Posttranscriptional Regulation Of Gene Expression Reproductive Structure Development Reproductive System Development Ovarian Follicle Development Oligodendrocyte Differentiation Ovulation Cycle Process Developmental Process Involved In Reproduction Glial Cell Development Female Gonad Development Response To Heat Ovulation Cycle Development Of Primary Female Sexual Characteristics Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Response To Glucose Myelination Axon Ensheathment Response To Endoplasmic Reticulum Stress Positive Regulation Of Hydrolase Activity Reproduction Glial Cell Differentiation Response To Carbohydrate Response To Temperature Stimulus Gene Expression Single Organism Reproductive Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Gliogenesis Male Germ Cell Proliferation Reproductive Process Negative Regulation Of Translational Initiation In Response To Stress Rhythmic Process Positive Regulation Of Catalytic Activity Cellular Protein Metabolic Process Negative Regulation Of Translation In Response To Stress Biosynthetic Process Response To Peptide Hormone Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Translational Initiation Response To Peptide	Regulation Of Translation In Response To Stress Regulation Of Translational Initiation In Response To Stress Regulation Of Translational Initiation Regulation Of Translation Negative Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Translation In Response To Stress Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Translational Initiation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Oligodendrocyte Development Regulation Of Cellular Protein Metabolic Process Translational Initiation Regulation Of Protein Metabolic Process Oligodendrocyte Differentiation Negative Regulation Of Translation Glial Cell Development Neurogenesis Response To Heat Cellular Protein Metabolic Process Positive Regulation Of Translational Initiation Response To Glucose Cell Development Positive Regulation Of Hydrolase Activity Response To Endoplasmic Reticulum Stress Negative Regulation Of Cellular Metabolic Process Glial Cell Differentiation Response To Carbohydrate Response To Temperature Stimulus Nervous System Development Protein Metabolic Process Regulation Of Catalytic Activity Translation Gliogenesis Cellular Response To Stress Positive Regulation Of Catalytic Activity Central Nervous System Development Ovarian Follicle Development Axon Guidance Positive Regulation Of Translation Reproduction Regulation Of Gene Expression Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Response To Abiotic Stimulus Cell Differentiation Positive Regulation Of Metabolic Process Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Stress
Tagcloud ?		1090c 1980s 314a 318a 877c ataxia atrophy compiled deterioration dystonic genetics hemiparesis hereditary leukoencephalopathy list macrocephaly manifestation matter movements necropsy optic spain spasticity suffered vanishing vwm	actb aging analysed comprehensive cows deltact differed dominant durations follicle follicles follicular fsh gapdh genorm geometric granulosa maternal normfinder preovulatory programs ranking reference reffinder rnf20 sf3a1 suitable threshold ube2d2
Tagcloud (Difference) ?		1090c 1980s 314a 318a 877c ataxia atrophy compiled deterioration dystonic genetics hemiparesis hereditary leukoencephalopathy list macrocephaly manifestation matter movements necropsy optic spain spasticity suffered vanishing vwm	actb aging analysed comprehensive cows deltact differed dominant durations follicle follicles follicular fsh gapdh genorm geometric granulosa maternal normfinder preovulatory programs ranking reference reffinder rnf20 sf3a1 suitable threshold ube2d2
Tagcloud (Intersection) ?